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Printable Handouts
Navigable Slide Index
- Introduction
- Factors to study in the evolution of resistance
- Antibiotic resistance by chromosomal mutation
- Mutation
- Likelihood of resistance emerging
- Diagram - a "jackpot" culture
- Diagram - a late mutation
- Diagram - which has the highest mutation rate?
- Mutation rate and mutation frequency - summary
- Determining mutation rate
- Overview on mutation rate experiments (1)
- Overview on mutation rate experiments (2)
- Range of detected mutations in an experiment
- MICs of different mutant strains of S. pneumoniae
- Parameters for planning mutation rate experiments
- Methods of calculation of mutation rates
- Variables for the calculation of mutation rate
- Equations used in the calculation of m
- Calculating mutation rate
- What do we mean by mutation rate?
- Assumptions in a fluctuation analysis
- Does cell state affect the mutation rate?
- No increase in mutation rate in low pH
- Chemostat at pH=7
- Chemostat at pH=6.2
- Hypermutability
- Rifampicin mutation frequency in CF patients
- Antibiotic resistance in CF patients
- Mutator strains belonging to E. coli and Shigella
- Mutator strains more likely to generate resistance
- Identifying mutator strains
- Mutation rates for first- and second-step mutants
- Antibiotics can increase mutation rate
- Case report of antibiotic resistance
- Reservoir of mutants in untreated patients
- Mutations in gyrA, parC
- Summary
Topics Covered
- Factors to study in the evolution of resistance
- Antibiotic resistance by chromosomal mutation
- Likelihood of resistance emerging
- Determining mutation rate
- Parameters for planning a mutation rate experiment
- Methods of calculating mutation rate
- Assumptions in a fluctuation analysis
- Environmental stresses in the host environment
- Hypermutability
Talk Citation
Gillespie, S. (2010, January 13). Mutation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2024, from https://doi.org/10.69645/NLWY7843.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Stephen Gillespie is in receipt of research grants from MMRC, EDCTP, Global Alliance for TB Drug Development. Professor Gillespie’s involvements in clinical trials are supported by active and placebo drug supplies from Bayer Schering Health Care and Sanofi Aventis, while also providing support with regulatory and drug safety advice. Neither company has a managerial role within the study, however. Professor Gillespie has also provided training to senior staff at Bayer Schering Health Care.