• Evolutionary Perspectives
• 42 min
  1. Antibiotic resistance: a mechanistic overview

  • Dr. Neil Woodford
• 20 min
  2. Mutation

  • Prof. Stephen Gillespie
• 11 min
  3. Fitness in antibiotic resistant bacteria

  • Prof. Stephen Gillespie
• 34 min
  4. Fitness and compensation

  • Dr. Sébastian Gagneux
• 22 min
  5. Antibiotic resistance and the supragenome hypothesis

  • Dr. Bambos Charalambous
• Epidemiology and Clinical Impact
• 37 min
  6. Methicillin resistant S. aureus and other resistances

  • Prof. Mark Enright
• 43 min
  7. Risk factors for antibiotic resistance in Streptococcus pneumoniae

  • Prof. Keith Klugman
• 38 min
  8. Beta-lactamases: clinical impact and epidemiology

  • Prof. Sebastian Amyes
• 49 min
  9. Glycopeptide-resistant enterococci

  • Dr. Neil Woodford
• 33 min
  10. Drug resistant tuberculosis: biology, epidemiology and control

  • Dr. Christopher Dye
• 26 min
  11. Antiretroviral drug resistance

  • Prof. Deenan Pillay
• 49 min
  12. Malaria - changing paradigms

  • Dr. Janet Cox-Singh
• 42 min
  13. Advances in mode of action of antimalarials and resistance mechanisms 1

  • Prof. David Warhurst
• 38 min
  14. Advances in mode of action of antimalarials and resistance mechanisms 2

  • Prof. David Warhurst
• Diagnosis and Surveillance of Resistance
• 29 min
  15. Conventional and automated diagnostic methods

  • Dr. Alan Johnson
• 38 min
  16. National and international surveillance of antibiotic resistance 1

  • Prof. David Livermore
• 50 min
  17. National and international surveillance of antibiotic resistance 2

  • Prof. David Livermore
• Controlling Antibiotic Resistance
• 39 min
  18. Controlling antibiotic resistance in the hospital environment

  • Dr. Ian Eltringham
• 27 min
  19. Controlling antibiotic resistance in the community

  • Dr. Peter Wilson
• 51 min
  20. Public policy to reduce antibiotic resistance

  • Dr. Niels Frimodt-Møller
• The Antibiotic Resistance Future
• 26 min
  21. Overcoming resistance through novel drug targets

  • Prof. Anthony Coates
• 37 min
  22. Medicinal chemistry strategies in combating antibiotic resistance

  • Dr. Geoffrey Coxon
• 36 min
  23. Teixobactin kills pathogens without detectable resistance

  • Prof. Kim Lewis
• Archived Lectures *These may not cover the latest advances in the field
• 48 min
  24. Molecular diagnosis of antibiotic resistance

  • Dr. Tim McHugh
• 36 min
  25. Introduction to malaria

  • Prof. David Warhurst

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Mechanisms of antibiotic action
3. Resistance is as old as antibiotics
4. Antibiotic resistance mechanisms
5. Types of resistance
6. Defining resistance
7. Susceptibility is an interplay of multiple factors
8. Antibiotics select resistant bacteria
9. Bacteria carry resistance in their DNA
10. Resistance is transferred (1)
11. Resistance is transferred (2)
12. The Red Queen Principle
13. Resistance is inevitable
14. How quickly does resistance emerge?
15. Oxazolidinone timeline
16. Mechanism 1: alteration of the target
17. The forensics of antibiotic resistance
18. Epidemiological investigation of resistance
19. Surveillance of resistance
20. An example of a trend noticed in surveillance
21. Mechanism 2: metabolic by-pass
22. Cephalosporin-resistant E. coli
23. Why might resistance rates rise?
24. Understanding rising prevalence
25. Mechanism 3: drug destruction
26. Global explosion of CTX-M ESBLs
27. Multi-resistance plasmids
28. The use of carbapenems
29. Mechanism 4: reduced uptake
30. Restore porins and reverse carbapenem resistance
31. Carbapenemase-mediated resistance in the UK
32. The OXA-23 clone 1
33. Mechanism 5: up-regulated efflux
34. Recap: mechanisms of resistance
35. Undefined mechanism of action
36. Undefined resistance mechanisms
37. Summary
38. Acknowledgements

Topics Covered

• Modes of antibiotic action
• Modes of resistance
• Intrinsic / acquired resistance
• Emergence and transfer of resistance
• Monitoring spread
• Modified targets
• Enzymic destruction
• ESBLs
• Plasmidic multi-resistance
• Impermeability / porin loss
• Carbapenemases
• Efflux pumps

Links

Series:

• Antibiotic Resistance

Categories:

• Cell Biology
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on December 31, 2009

Financial Disclosures

• Dr. Neil Woodford has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.