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- Principles in Bacterial Pathogenesis
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1. The molecular basis of bacterial pathogenicity: an overview
- Prof. B. Brett Finlay
- Gram Negative Pathogens
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2. Deciphering shigella invasion of epithelial cells
- Prof. Philippe Sansonetti
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5. Bordetella pertussis
- Prof. Alison Weiss
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6. Salmonellae: molecular basis of infection
- Prof. Samuel Miller
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7. The diversity of Escherichia coli infections
- Prof. Michael Donnenberg
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8. Bacterial activation of epithelial signaling
- Prof. Alice Prince
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9. Human pathogenic Yersinia species
- Prof. James Bliska
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11. Dental pathogens
- Prof. Ann Progulske-Fox
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12. Haemophilus
- Prof. Robert Munson
- Gram Positive Pathogens
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13. The bacterial pathogen Listeria monocytogenes: an amazing multifaceted model
- Prof. Pascale Cossart
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15. Molecular pathogenesis and prevention of Staphylococcus aureus infections
- Prof. Olaf Schneewind
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16. Streptococcus pyogenes disease and molecular pathogenesis
- Prof. P. Patrick Cleary
- Host Responses
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17. Microbial recognition and the immune response
- Dr. Dana Philpott
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18. Toll-like receptor signalling during infection and inflammation
- Prof. Luke O'Neill
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19. The human indigenous microbiota
- Prof. David Relman
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21. Role of neutrophils in acute lung injury and repair
- Prof. Gregory Downey
- Preventatives and Therapeutics
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22. Antibiotics and antibiotic resistance
- Prof. Gerry Wright
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23. Vaccines: a health insurance of the 21st century
- Prof. Rino Rappuoli
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24. Biodefense vaccines
- Prof. James Nataro
- Archived Lectures *These may not cover the latest advances in the field
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25. Vaccines in the modern world
- Prof. Gordon Dougan
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26. Bacterial infection of epithelial signaling
- Prof. Alice Prince
Printable Handouts
Navigable Slide Index
- Introduction
- Concept through proof of concept
- Epidemiological observations
- Methods of investigation in humans
- Mendelian and complex inheritance
- Mendelian genetics
- Invasive pneumococcal disease (IPD)
- Genetic disorders in the NF-KB signaling pathway
- IRAK-4/MyD88 deficiencies
- The genus Mycobacterium
- MSMD
- Gene mutations in MSMD
- IL12R-beta1 deficiency and tuberculosis (TB)
- Mendelian TB proportion in disseminated forms
- Investigation of common infectious diseases
- Tuberculosis and leprosy
- TB: individual variability in response to infection
- Complex TB inheritance: candidate genes
- Complex TB inheritance: major gene
- TB: genome-wide linkage screen
- Linkage to chromosome 8q12-q13
- Leprosy: response to M. leprae
- Leprosy clinical features
- Leprosy epidemiology
- Countries with increasing incidence
- Difficulties in investigating leprosy
- Leprosy per se
- Leprosy linkage analysis (1)
- Leprosy linkage analysis (2)
- Family-based association study
- Primary scan
- Results of the association study
- Exact replication in the same population (1)
- Exact replication in the same population (2)
- Case-control replication in Northern India (1)
- Case-control replication in Northern India (2)
- LTA+80 A allele effect on leprosy susceptibility
- Case-control replication in Brazil
- LTA+80 A allele effect in the Brazilian population
- Age at leprosy diagnosis
- Performing the analysis by age
- Concluding remarks on leprosy
- Continuous spectrum
- Genetic spectrum depends on age
- Acknowledgements (1)
- Acknowledgements (2)
- Some reviews in the subject
Topics Covered
- General strategy for investigating human genes in infectious diseases
- A continuous spectrum from Mendelian to complex predisposition
- Mendelian predisposition to invasive pneumococcal disease
- Mendelian predisposition to mycobacterial infections including tuberculosis
- Complex predisposition to tuberculosis and leprosy
Links
Series:
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Talk Citation
Abel, L. (2009, October 29). Human genetics of infectious diseases: the example of bacterial/mycobacterial infections [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 24, 2024, from https://hstalks.com/bs/1483/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Laurent Abel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Human genetics of infectious diseases: the example of bacterial/mycobacterial infections
Published on October 29, 2009
53 min
A selection of talks on Microbiology
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