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- Principles in Bacterial Pathogenesis
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1. The molecular basis of bacterial pathogenicity: an overview
- Prof. B. Brett Finlay
- Gram Negative Pathogens
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2. Deciphering shigella invasion of epithelial cells
- Prof. Philippe Sansonetti
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5. Bordetella pertussis
- Prof. Alison Weiss
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6. Salmonellae: molecular basis of infection
- Prof. Samuel Miller
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7. The diversity of Escherichia coli infections
- Prof. Michael Donnenberg
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8. Bacterial activation of epithelial signaling
- Prof. Alice Prince
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9. Human pathogenic Yersinia species
- Prof. James Bliska
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11. Dental pathogens
- Prof. Ann Progulske-Fox
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12. Haemophilus
- Prof. Robert Munson
- Gram Positive Pathogens
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13. The bacterial pathogen Listeria monocytogenes: an amazing multifaceted model
- Prof. Pascale Cossart
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15. Molecular pathogenesis and prevention of Staphylococcus aureus infections
- Prof. Olaf Schneewind
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16. Streptococcus pyogenes disease and molecular pathogenesis
- Prof. P. Patrick Cleary
- Host Responses
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17. Microbial recognition and the immune response
- Dr. Dana Philpott
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18. Toll-like receptor signalling during infection and inflammation
- Prof. Luke O'Neill
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19. The human indigenous microbiota
- Prof. David Relman
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21. Role of neutrophils in acute lung injury and repair
- Prof. Gregory Downey
- Preventatives and Therapeutics
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22. Antibiotics and antibiotic resistance
- Prof. Gerry Wright
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23. Vaccines: a health insurance of the 21st century
- Prof. Rino Rappuoli
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24. Biodefense vaccines
- Prof. James Nataro
- Archived Lectures *These may not cover the latest advances in the field
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25. Vaccines in the modern world
- Prof. Gordon Dougan
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26. Bacterial infection of epithelial signaling
- Prof. Alice Prince
Printable Handouts
Navigable Slide Index
- Introduction
- Important streptococcal species
- S. agalactiae - neonatal sepsis and meningitis
- S. pneumoniae
- S. pneumoniae - a candy coated bacterium
- S. pyogenes - the chain that links throat to heart
- S. pyogenes infections
- Serious life threatening complications
- Rheumatic fever - link to the heart
- APSGN (1)
- APSGN (2)
- Invasive S. pyogenes disease
- Child-bed sepsis (puerperal sepsis)
- Others conditions associated with S. pyogenes
- Psoriasis and obsessive compulsive behavior
- Microbiology of S. pyogenes
- Identification of group A Streptococcus
- S. pyogenes is resistant to innate immunity
- S. pyogenes interaction with host cell
- S. pyogenes surface is determinant of virulence
- Masters of immune avoidance
- Molecular mimicry - hyaluronic acid
- Binding of HA to CD44
- Key complement components
- Destruction of host chemotactic signals
- C5a peptidase (1)
- C5a peptidase (2)
- The M protein (1)
- The M protein (2)
- Tonsils are reservoir for recurrent infection
- S. pyogenes enter tonsils through M cells
- Streptococcal adhesins and invasins
- Multiple pathways of invasion
- M1-Fn and Sfb1-Fn invasion signals
- S. pyogenes infection and TGF-beta (1)
- S. pyogenes infection and TGF-beta (2)
- Superantigens
- Superantigens are nonspecific activators of T cells
- Summary
Topics Covered
- Important Streptococcal species
- S. pyogenes: the chain that links the throat to the heart
- Life threatening complications
- Rheumatic fever
- Acute post streptococcal glomerulonephritis
- Invasive S. pyogenes disease
- Strep throat activates psoriasis and obsessive compulsive behavior
- Identification of group A streptococcus
- S. pyogenes expresses a complex array of factors that interact with host defenses
- Molecular mimicry hides bacterium from host's defenses
- Key complement components
- Destruction of host chemotactic signals is critical for initiation of infection
- C5a peptidase
- M protein
- Tonsils are reservoir for recurrent infection
- Superantigens
Links
Series:
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Talk Citation
Cleary, P.P. (2009, October 29). Streptococcus pyogenes disease and molecular pathogenesis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 25, 2024, from https://hstalks.com/bs/1480/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. P. Patrick Cleary, Lecturer, shared royalty payments from sales of lecture series.