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- Principles in Bacterial Pathogenesis
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1. The molecular basis of bacterial pathogenicity: an overview
- Prof. B. Brett Finlay
- Gram Negative Pathogens
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2. Deciphering shigella invasion of epithelial cells
- Prof. Philippe Sansonetti
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5. Bordetella pertussis
- Prof. Alison Weiss
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6. Salmonellae: molecular basis of infection
- Prof. Samuel Miller
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7. The diversity of Escherichia coli infections
- Prof. Michael Donnenberg
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8. Bacterial activation of epithelial signaling
- Prof. Alice Prince
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9. Human pathogenic Yersinia species
- Prof. James Bliska
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11. Dental pathogens
- Prof. Ann Progulske-Fox
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12. Haemophilus
- Prof. Robert Munson
- Gram Positive Pathogens
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13. The bacterial pathogen Listeria monocytogenes: an amazing multifaceted model
- Prof. Pascale Cossart
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15. Molecular pathogenesis and prevention of Staphylococcus aureus infections
- Prof. Olaf Schneewind
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16. Streptococcus pyogenes disease and molecular pathogenesis
- Prof. P. Patrick Cleary
- Host Responses
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17. Microbial recognition and the immune response
- Dr. Dana Philpott
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18. Toll-like receptor signalling during infection and inflammation
- Prof. Luke O'Neill
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19. The human indigenous microbiota
- Prof. David Relman
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21. Role of neutrophils in acute lung injury and repair
- Prof. Gregory Downey
- Preventatives and Therapeutics
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22. Antibiotics and antibiotic resistance
- Prof. Gerry Wright
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23. Vaccines: a health insurance of the 21st century
- Prof. Rino Rappuoli
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24. Biodefense vaccines
- Prof. James Nataro
- Archived Lectures *These may not cover the latest advances in the field
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25. Vaccines in the modern world
- Prof. Gordon Dougan
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26. Bacterial infection of epithelial signaling
- Prof. Alice Prince
Printable Handouts
Navigable Slide Index
- Introduction
- Bordetella pertussis
- Whooping cough (or pertussis)
- Whooping cough case presentation
- Pertussis: a medical success story, with its limits
- Pertussis in the US, 1980-2008
- Pertussis is a cyclic
- Pertussis vaccine
- Vaccine efficacy following household exposure
- Pertussis vaccine promotes little herd immunity
- Pertussis vs. Influenza vaccine
- Immunization does not yield life-long immunity
- Pertussis by age group
- The molecular aspect of whooping cough
- Classical whooping cough
- Chronic coughing disease
- Pertussis is two diseases
- B. pertussis is a strict human pathogen
- Infection causes suboptimal immune responses
- Virulence factors of B. pertussis - toxins
- Pertussis toxin
- Adenylate cyclase toxin (ACT)
- ACT inhibits neutrophil phagocytosis
- Dermonecrotic toxin
- Tracheal cytotoxin
- Virulence factors of B. pertussis - adhesins
- Adhesins of B. pertussis
- Adhesins - not just sticky proteins
- Composition of acellular pertussis vaccine
- Vaccine induced antibody-mediated immunity
- Anti-toxin antibodies
- Anti-adherence antibodies
- Bactericidal antibodies
- Opsono-phagocytosis
- Phagocytosis assay
- Neutrophil phagocytosis
- Neutralizing Ab to ACT promote phagocytosis
- Opsono-phagocytosis activity after vaccination
- Vaccine does not enhance phagocytosis
- Opsono-phagocytosis activity after infection
- Phagocytosis with convalescent serum
- ACT blocks phagocytosis in WT
- Phagocytosis with serum depleted for Ab to FHA
- FHA is both bound to the bacteria and secreted
- Ab to FHA delivers ACT to neutrophils
- Role of Complement in immunity to B. pertussis
- Complement killing assay
- Complement cascade
- Complement killing activity after vaccination
- Complement activity after vaccination
- Complement killing activity after infection
- Blocking response decays with time
- IgA involvement in blocking activity
- Antibody dependent complement killing
- Summary
- Acknowledgements
- Thank you
Topics Covered
- Pertussis: a medical success story and the limits of medical success
- Pertussis is the only vaccine-preventable disease that is increasing in incidence in the USA
- Pertussis is cyclic
- Pertussis vaccine and its efficacy
- Vaccine prevents disease not carriage
- Immunization does not yield life-long immunity
- Human to human transmission by respiratory droplets
- Classical whooping cough and chronic coughing disease
- Pertussis is two diseases
- B. pertussis is a strict human pathogen
- Virulence factors of Bordetella pertussis
- Pertussis toxin
- Adhesins
- Composition of acellular pertussis vaccine
- Anti-toxin, anti-adherence and bactericidal antibodies
- Opsono-phagocytosis
- Role of complement in immunity to B. pertussis
Links
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Talk Citation
Weiss, A. (2009, October 29). Bordetella pertussis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 25, 2024, from https://hstalks.com/bs/1467/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Alison Weiss has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.