Registration for a live webinar on 'Innate immunity, inflammation and cancer' is now open.
See webinar details
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- Principles in Bacterial Pathogenesis
-
43 min
1. The molecular basis of bacterial pathogenicity: an overview- Prof. B. Brett Finlay
- Gram Negative Pathogens
-
50 min
2. Deciphering shigella invasion of epithelial cells- Prof. Philippe Sansonetti
-
43 min
-
57 min
-
34 min
5. Bordetella pertussis- Prof. Alison Weiss
-
37 min
6. Salmonellae: molecular basis of infection- Prof. Samuel Miller
-
43 min
7. The diversity of Escherichia coli infections- Prof. Michael Donnenberg
-
18 min
8. Bacterial activation of epithelial signaling- Prof. Alice Prince
-
48 min
9. Human pathogenic Yersinia species- Prof. James Bliska
-
32 min
-
46 min
11. Dental pathogens- Prof. Ann Progulske-Fox
-
35 min
12. Haemophilus- Prof. Robert Munson
- Gram Positive Pathogens
-
53 min
13. The bacterial pathogen Listeria monocytogenes: an amazing multifaceted model- Prof. Pascale Cossart
-
42 min
-
48 min
15. Molecular pathogenesis and prevention of Staphylococcus aureus infections- Prof. Olaf Schneewind
-
49 min
16. Streptococcus pyogenes disease and molecular pathogenesis- Prof. P. Patrick Cleary
- Host Responses
-
29 min
17. Microbial recognition and the immune response- Dr. Dana Philpott
-
47 min
18. Toll-like receptor signalling during infection and inflammation- Prof. Luke O'Neill
-
56 min
19. The human indigenous microbiota- Prof. David Relman
-
53 min
-
47 min
21. Role of neutrophils in acute lung injury and repair- Prof. Gregory Downey
- Preventatives and Therapeutics
-
35 min
22. Antibiotics and antibiotic resistance- Prof. Gerry Wright
-
36 min
23. Vaccines: a health insurance of the 21st century- Prof. Rino Rappuoli
-
41 min
24. Biodefense vaccines- Prof. James Nataro
- Archived Lectures *These may not cover the latest advances in the field
-
39 min
25. Vaccines in the modern world- Prof. Gordon Dougan
-
39 min
26. Bacterial infection of epithelial signaling- Prof. Alice Prince
Printable Handouts
Navigable Slide Index
- Introduction
- Lecture outline
- History of the cholera disease
- Vibrio cholerae - epidemiology
- Zimbabwe cholera epidemic 2008
- V. cholerae and the cholera disease
- V. cholerae: classification
- Cholera pandemics
- Cholera - the disease
- Cholera mortality can be 80% if untreated
- Problem of IV rehydration
- International center for diarrheal disease research
- Cholera pediatric ward at the ICDDR,B
- "Cholera cot"
- Rice water cholera stool
- Highlights in the history of V. cholerae research
- Rabbit intestinal loop assay
- Cholera toxin: 10ug = 20L of diarrhea in volunteers
- Colonization of the upper intestine is intense
- TCP pili bundles required for intestinal colonization
- TCP mediates formation of microcolonies in vitro
- Adherence of V. cholerae to epithelial cells
- Cholera pathogenesis
- V. cholerae is at home in water
- Conclusions from comparative genomics
- The TCP island of V. cholerae
- Cholera toxin is encoded by a filamentous phage
- Structure of the CTX prophage
- Model for emergence of pathogenic V. cholerae
- Coordinate regulation of TCP and CT
- Construction of a V. cholerae microarray
- Profiling of V. cholerae in Bangladesh
- TCP and ToxT upregulated in vomitus samples
- Conclusions from clinical samples analysis
- "Quorum sensing" measures cell density
- Analyzing cholera epidemics
- Are there any small molecules useful as drugs?
- Screen for inhibitors of ctxA transcription
- Virstatin: effect on CT and TcpA production
- Virstatin in vitro
- Virstatin in vivo
- Virstatin - first inhibitor of microbial virulence
- A seasonal cholera epidemic in Bangladesh
- What influences the seasonality of cholera?
- Environmental phage and V. cholerae isolation
- Vibriophages prevalent in Dhaka city
- Vibriophages and V. cholerae in water samples
- Incidence of cholera and phage isolation
- Cholera incidence and phage isolation - summary
- Influence of phage on cholera epidemic seasonality
- Cholera epidemic emerged after a flood in Dhaka
- Dhaka epidemic - V. cholerae and phages
- Dhaka epidemic - presence of phages in stools
- Model for the role of phage in cholera seasonality
- Phenotypic differences between biotypes
- Conclusions
- Types of cholera vaccines
- Results of Peru 15 study in adults
- Peru 15 study in infants
- Summary of results in toddlers and infants
- Acknowledgements
Topics Covered
- Vibrio cholerae epidemiology and classification
- Vibrio cholerae and cholera
- Cholera mortality
- The history of V. cholerae research
- Cholera toxin and pathogenesis
- Comparative genomics
- The TCP Island of Vibrio cholerae
- Structure of the CTX prophage
- Vibrio cholerae microarray
- Clinical sample analysis
- Virstatin
- What influences the seasonality and epidemiology of cholera?
- Vibriophages
- Cholera incidence as a function of environmental phage isolation and concentration
- Phenotypic differences between biotypes
- Types of cholera vaccines
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Mekalanos, J. (2009, October 29). Cholera: a paradigm for understanding emergence, virulence and temporal patterns of disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 16, 2024, from https://hstalks.com/bs/1466/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. John Mekalanos has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Cholera: a paradigm for understanding emergence, virulence and temporal patterns of disease
Published on October 29, 2009
57 min
A selection of talks on Infectious Diseases
Hide