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- Principles in Bacterial Pathogenesis
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1. The molecular basis of bacterial pathogenicity: an overview
- Prof. B. Brett Finlay
- Gram Negative Pathogens
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2. Deciphering shigella invasion of epithelial cells
- Prof. Philippe Sansonetti
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5. Bordetella pertussis
- Prof. Alison Weiss
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6. Salmonellae: molecular basis of infection
- Prof. Samuel Miller
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7. The diversity of Escherichia coli infections
- Prof. Michael Donnenberg
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8. Bacterial activation of epithelial signaling
- Prof. Alice Prince
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9. Human pathogenic Yersinia species
- Prof. James Bliska
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11. Dental pathogens
- Prof. Ann Progulske-Fox
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12. Haemophilus
- Prof. Robert Munson
- Gram Positive Pathogens
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13. The bacterial pathogen Listeria monocytogenes: an amazing multifaceted model
- Prof. Pascale Cossart
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15. Molecular pathogenesis and prevention of Staphylococcus aureus infections
- Prof. Olaf Schneewind
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16. Streptococcus pyogenes disease and molecular pathogenesis
- Prof. P. Patrick Cleary
- Host Responses
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17. Microbial recognition and the immune response
- Dr. Dana Philpott
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18. Toll-like receptor signalling during infection and inflammation
- Prof. Luke O'Neill
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19. The human indigenous microbiota
- Prof. David Relman
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21. Role of neutrophils in acute lung injury and repair
- Prof. Gregory Downey
- Preventatives and Therapeutics
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22. Antibiotics and antibiotic resistance
- Prof. Gerry Wright
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23. Vaccines: a health insurance of the 21st century
- Prof. Rino Rappuoli
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24. Biodefense vaccines
- Prof. James Nataro
- Archived Lectures *These may not cover the latest advances in the field
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25. Vaccines in the modern world
- Prof. Gordon Dougan
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26. Bacterial infection of epithelial signaling
- Prof. Alice Prince
Printable Handouts
Navigable Slide Index
- Introduction
- Shigella invasion process
- Histopathology of shigellosis
- Functional genomics of S. flexneri
- The shigellosis disease process
- Two mechanisms for bacterial penetration
- pWR100: the virulence plasmid of S. flexneri 5a
- The Shigella invasion pathogenicity island
- Assembly of type III protein delivery system
- IpaB and IpaD: sensor-adaptor at the needle tip
- Shigella trigger mechanism for cell invasion
- Signaling in the penetration process
- Cortactin - second wave of signaling
- IpaC induces Src autophosphorylation
- Src is activated early at Shigella entry site
- Src is necessary for actin foci formation
- Cortactin silencing blocks the entry process
- C351 insertion in IpaC effector C-terminal domain
- IpaC last 72 aa induce actin-foci-like structures
- IpaC-dependent actin nucleation
- Shigella motility within and between the cells
- Actin-dependent intracellular motility of Shigella
- Shigella intracellular motility - video
- Entry and cell-to cell spread of Shigella
- Acknowledgements
Topics Covered
- A genetic and molecular analysis of the mechanisms used by the bacterial pathogen Shigella to invade epithelial cells
- Identification of bacterial effectors of invasion, mode of delivery, nature of cell targets
- How a bacterial pathogen like Shigella causes the rupture and inflammatory destruction of the intestinal epithelial barrier
- How it also regulates the inflammatory response
- The accent is on identification of the bacterial effectors and their cellular targets
Links
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Talk Citation
Sansonetti, P. (2009, October 29). Deciphering shigella invasion of epithelial cells [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 20, 2024, from https://hstalks.com/bs/1464/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Philippe Sansonetti has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.