• How Natural Killer Cells Recognize Self
• 53 min
  1. Education and tuning of natural killer cells

  • Prof. Eric Vivier
  • Dr. Sophie Ugolini
• 46 min
  2. Disarming of autoreactive NK cells

  • Prof. David Raulet
• Development and Function of Natural Killer Cell Subsets
• 23 min
  3. Natural killer cell development

  • Dr. Francesco Colucci
• 48 min
  4. Natural killer cells: development, diversity and applications to human disease

  • Prof. Mike Caligiuri
• 41 min
  5. NK cells in viral immunity

  • Prof. Lewis Lanier
• 58 min
  6. NK cell subsets and interactions with dendritic cells

  • Prof. Christian Münz
• 53 min
  7. Immunodeficiencies and genetic mutations affecting NK cells in humans

  • Dr. Jordan Orange
• Natural Killer Cell Receptors and Signaling
• 42 min
  8. Evolution of NK cell receptors

  • Prof. John Trowsdale
• 26 min
  9. The influence of variation at the killer cell immunoglobulin-like receptor gene complex on human disease

  • Dr. Mary Carrington
• 37 min
  10. Mechanisms of natural killer cell cytotoxicity

  • Prof. Carsten Watzl
• 55 min
  11. NK cell signaling to cytotoxicity - part I

  • Prof. Dan Billadeau
• 39 min
  12. NK cell signaling to cytotoxicity - parts II & III

  • Prof. Dan Billadeau
• Archived Lectures *These may not cover the latest advances in the field
• 38 min
  13. NK cells in viral immunity

  • Prof. Lewis Lanier

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. NK cell functions
3. NK cell inhibition
4. NK cell activation (missing self)
5. NK cells in defense
6. Measuring cytotoxicity
7. The NK cell lytic immunological synapse
8. NK cell synapse (3-D reconstruction)
9. NK cell synapse (electron micrograph)
10. NK cells and human single gene deficiencies
11. Wiskott-Aldrich syndrome and NK cells
12. NK cell deficiency in Wiskott-Aldrich syndrome
13. WASp function
14. WASp and F-actin accumulation
15. WASP deficiency affects F-actin accumulation
16. WASp is essential for synapse events
17. Lytic granule traffic requires microtubules
18. The sequence of events leading to the synapse
19. Stages of lytic immunological synapse formation
20. Steps in lytic immunological synapse formation
21. A video of immunological synapse formation
22. Case presentation I - history
23. Case presentation II- laboratory studies
24. Case presentation III - clinical course
25. Case presentation IV - NK cell function
26. HLH diagnostic guidelines
27. Management of HLH
28. Case presentation V - diagnosis of FEL3
29. Hematophagocytic lymphohistiocytosis
30. Model for HLH
31. Molecular defects leading to HLH
32. Steps in immune-mediated cytolysis
33. Single gene diseases and NK cell defects (1)
34. Single gene diseases and NK cell defects (2)
35. NK cell population: age-specific normal varies
36. Isolated deficiencies of NK cells in humans
37. ANKD
38. CNKD
39. FNKD
40. What suggests NKD
41. Practical approach to NKD
42. Comprehensive approach to NKD
43. Management of NKD
44. Conclusions

Topics Covered

• NK cell deficiency
• Critical role of NK cells in human host defense
• Recognition of NK cell deficiencies in the context of other genetic human immunodeficiency
• Phenotypes of isolated NK cell deficiencies
• Insights into basic NK cell biology and immunity from experiments of nature

Links

Series:

• Natural Killer Cell Biology

Categories:

• Genetics & Epigenetics
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on September 23, 2009

Financial Disclosures

• Dr. Jordan Orange has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.