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- Co-ordination of G1 Progression
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1. START control in yeast
- Prof. Curt Wittenberg
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2. The pRB/E2F pathway
- Prof. Jacqueline Lees
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3. Cell cycle control by the ubiquitin system in mammals
- Prof. Michele Pagano
- Chromosome Duplication
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4. Replication licensing
- Prof. Julian Blow
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5. Initiation of DNA replication
- Prof. Bruce Stillman
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6. Regulation of replication fork progression and stability
- Dr. Luis Aragón
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7. Nucleosome assembly during DNA replication
- Dr. Alain Verreault
- Preparing for Mitosis
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8. Sister chromatid cohesion: simple concept, complex reality
- Prof. Douglas Koshland
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9. Mitotic chromosome condensation
- Prof. Andrew Belmont
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10. Centrosome duplication and separation in animal cells
- Prof. Andrew Fry
- Spindle Assembly and Chromosome Segregation
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11. Bipolar spindle assembly
- Dr. Eric Karsenti
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12. Chromosome bi-orientation in yeast
- Prof. Mike Stark
- Prof. Tomo Tanaka
- Mitotic Exit and Cytokinesis
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14. Cleavage furrow formation and ingression during animal cytokinesis
- Dr. Pier Paolo D'Avino
- Checkpoints Governing Cell Cycle Progression
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15. The DNA damage response
- Dr. Vincenzo Costanzo
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16. The spindle checkpoint
- Dr. Kevin Hardwick
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17. Spindle movement and checkpoint control during mitosis in yeast
- Prof. John Cooper
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18. The G2/M transition
- Prof. Dr. René Medema
- The Cell Cycle in Development and Cancer
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19. Mouse models to investigate cell cycle and cancer
- Dr. Philipp Kaldis
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20. Cell cycle: a complex network of signals regulating cell proliferation
- Prof. Antonio Giordano
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21. Drug discovery and target validation in the p53 pathway
- Prof. Sir David Lane
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22. Role and regulation of Cdk inhibitors in development and cancer
- Prof. Martine Roussel
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24. The Myc transcription factor network
- Prof. Robert N. Eisenman
- Meiosis: A Specialized Cell Cycle
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25. Recombination and the formation of chiasmata in meiosis
- Prof. Matthew Whitby
- Archived Lectures *These may not cover the latest advances in the field
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26. Geometric regulation of kinetochore orientation
- Prof. Yoshinori Watanabe
Printable Handouts
Navigable Slide Index
- Introduction
- Talk topics
- The kinetochore
- Molecular composition of the human kinetochore
- Kinetochore proteins assemble in a temporal order
- CENP-F localization at different stages of G2
- Defining temporal orders of assembly
- FRAP studies and kinetochore
- Turnover dynamics of kinetochore proteins
- What is the kinetochore?
- CENP-E: a kinesin like motor
- CENP-E exhibits a dynamic localization pattern
- CENP-E is essential for microtubule attachment
- The HEC1/Ndc80 complex
- Different phenotypes for various depletions
- Three steps of the mitotic checkpoint pathway
- Checkpoint proteins localize to kinetochores
- The kinetochore and its relation to cancer
- The mitotic checkpoint and cancer
- Mitotic checkpoint genes are essential
- Mitotic checkpoints and genome instability
- The kinetochore as a mitosis specific target
- Inhibitors of mitosis
- Ansamycins are inhibitors of Hsp90
- 17-AAG blocks assembly of CENP-H and I
- Histone deacetylase inhibitors
- HDI delays human tumor cell lines in mitosis
- HDI interferes protein assembly onto kinetochore
- Not all kinetochore localized proteins are affected
- The depletion is not a result of degradation
- FTI's block farnesylation of proteins
- FTI-2153 alters the localization of CENP-F
- Effect of FTI on lung cancer cells
- Inhibitors of kinetochore/spindle proteins
- Kinase inhibitors-Aurora and Plk1
- Polo kinases - Plk1-4
- Pros and cons of targeting the mitotic checkpoint
- Linking chromosome missegregation to cell death
- The checkpoint and apoptosis pathways
- Hela cells depleted of hNuf2 accumulate in mitosis
- Timelapse videos of mitotically arrested cells
- Hela cells blocked in mitosis undergo apoptosis
- Patient response
- Conclusions and future directions
Topics Covered
- Mitosis is critical for cells to proliferate and is a major target of current anti-cancer drugs such as paclitaxel and vinca alkaloids
- Characterization of proteins essential for mitosis has made available the opportunity to develop new anti-mitotic agents
- Expanding the number of anti-cancer drug targets should significantly improve the response of tumors to chemotherapies
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Yen, T. (2009, May 3). The kinetochore as a target for the development of mitosis specific anti-cancer drugs [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 25, 2024, from https://hstalks.com/bs/1273/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Tim Yen has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Oncology
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