Registration for a live webinar on 'Innate immunity, inflammation and cancer' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- Co-ordination of G1 Progression
-
1. START control in yeast
- Prof. Curt Wittenberg
-
2. The pRB/E2F pathway
- Prof. Jacqueline Lees
-
3. Cell cycle control by the ubiquitin system in mammals
- Prof. Michele Pagano
- Chromosome Duplication
-
4. Replication licensing
- Prof. Julian Blow
-
5. Initiation of DNA replication
- Prof. Bruce Stillman
-
6. Regulation of replication fork progression and stability
- Dr. Luis Aragón
-
7. Nucleosome assembly during DNA replication
- Dr. Alain Verreault
- Preparing for Mitosis
-
8. Sister chromatid cohesion: simple concept, complex reality
- Prof. Douglas Koshland
-
9. Mitotic chromosome condensation
- Prof. Andrew Belmont
-
10. Centrosome duplication and separation in animal cells
- Prof. Andrew Fry
- Spindle Assembly and Chromosome Segregation
-
11. Bipolar spindle assembly
- Dr. Eric Karsenti
-
12. Chromosome bi-orientation in yeast
- Prof. Mike Stark
- Prof. Tomo Tanaka
- Mitotic Exit and Cytokinesis
-
14. Cleavage furrow formation and ingression during animal cytokinesis
- Dr. Pier Paolo D'Avino
- Checkpoints Governing Cell Cycle Progression
-
15. The DNA damage response
- Dr. Vincenzo Costanzo
-
16. The spindle checkpoint
- Dr. Kevin Hardwick
-
17. Spindle movement and checkpoint control during mitosis in yeast
- Prof. John Cooper
-
18. The G2/M transition
- Prof. Dr. René Medema
- The Cell Cycle in Development and Cancer
-
19. Mouse models to investigate cell cycle and cancer
- Dr. Philipp Kaldis
-
20. Cell cycle: a complex network of signals regulating cell proliferation
- Prof. Antonio Giordano
-
21. Drug discovery and target validation in the p53 pathway
- Prof. Sir David Lane
-
22. Role and regulation of Cdk inhibitors in development and cancer
- Prof. Martine Roussel
-
24. The Myc transcription factor network
- Prof. Robert N. Eisenman
- Meiosis: A Specialized Cell Cycle
-
25. Recombination and the formation of chiasmata in meiosis
- Prof. Matthew Whitby
- Archived Lectures *These may not cover the latest advances in the field
-
26. Geometric regulation of kinetochore orientation
- Prof. Yoshinori Watanabe
Printable Handouts
Navigable Slide Index
- Introduction
- Chromosome structure and function
- Smc complexes
- EM pictures of Smc complexes
- Soluble Smc complex structure
- Cohesin as prototype for Smc complex function
- Cohesin and sister chromatid cohesion
- Kinetochore attachment - without cohesion
- Kinetochore attachment - with cohesion
- Cohesion as boundaries for condensation
- Cohesin and transcription domains
- Cohesion promotes chromosome integrity
- Budding yeast as a model
- Yeast chromosome structure is an oxymoron
- Assaying cohesion in yeast by fluorescence
- Cohesin subunits and auxiliary factors
- Regulation of cohesin loading onto chromosomes
- Eco1 and cell cycle regulation of cohesion
- Eco1 and DNA damage induced cohesion
- Why complex regulation of the cohesive state?
- Cohesion maintenance
- The dissolution of cohesion at anaphase onset
- Summary of the complex regulation of cohesin
- The embrace model for chromatin binding (1)
- Alternate model for Smc tethering
- Smc3 head is key regulator to convert cohesin
- Summary of the Snap and embrace models
- So many important questions still to be answered
- Acknowledgments
Topics Covered
- Sister chromatid cohesion: simple concept complex reality
- Overview of higher order chromosome structure
- Smc (structural maintenance of chromosomes) complexes as mediators of higher order chromosome structure
- Introduction to cohesin, the Smc complex that mediates sister chromatid cohesion
- Biological function of cohesion
- Cohesin binding to chromatin
- Establishment, maintenance and dissolution of cohesion
- The molecular basis of cohesins as chromatid tethers
Talk Citation
Koshland, D. (2009, April 30). Sister chromatid cohesion: simple concept, complex reality [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 20, 2024, from https://hstalks.com/bs/1259/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Douglas Koshland has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Sister chromatid cohesion: simple concept, complex reality
Published on April 30, 2009
27 min