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1. Introduction
2. Global prevalance of obesity
3. Current and coming anti-obesity agents
4. Bariatric surgery - the only successful therapy
5. Skin redundancy after massive weight loss
6. The gut hormones
7. Ghrelin
8. Energy intake after administration of ghrelin
9. Meal intake after ghrelin infusion in cancer patients
10. Why do you feel less hungry after a meal?
11. Gut hormones: three types of satiety action
12. Peptide YY (PYY) (1)
13. GI tract distribution of PYY
14. Post prandial secretion of PYY
15. Peptide YY (PYY) (2)
16. PYY levels in different patients
17. PYY levels elevated post bypass surgery
18. Effect of PYY3-36 on food intake (1)
19. Effect of PYY3-36 on food intake (2)
20. Effect of PYY3-36 on cumulative 24h food intake
21. PYY3-36 hunger scores
22. PYY3-36 on ghrelin
23. PYY levels during saline infusion
24. Meal calories and PYY blood level in fat and thin
25. Plasma PYY levels at each infusion dose
26. Percent reduction in calories after PYY infusion
27. Food intake increased after PYY
28. Three characteristics of PYY3-36 on appetite
29. Glucagon-like peptide 1
30. The effect of chronic GLP-1 on body weight
31. Exendin stimulates food intake in satiated rats
32. 24 week trial of exenatide against insulin glargine
33. 82 weeks follow up
34. Oxyntomodulin (1)
35. Oxyntomodulin (2)
36. Chronic IP administration of oxyntomodulin
37. Effect of oxyntomodulin on food intake in humans
38. Four week oxyntomodulin trial
39. Trial protocol
40. Type of administration
41. Oxyntomodulin effect on weight loss
42. Oxyntomodulin effect on leptin levels
43. Oxyntomodulin effect on calorie intake
44. Oxyntomodulin effect on insulin levels
45. Effect on energy expenditure
46. Oxyntomodulin and energy balance
47. Design of oxyntomodulin analogues
48. Oxyntomodulin analogue 23/36
49. Effect of oxyntomodulin analogue on weight loss
50. Oxyntomodulin versus GLP-1
51. Manganese enhanced MRI
52. Ghrelin manganese enhanced MRI
53. GLP1 against oxyntomodulin
54. Buffet meal energy intake
55. Human pancreatic polypeptide (1)
56. Human pancreatic polypeptide (2)
57. Effect of hPP analogues on food intake
58. Effect of PYY, hPP or combination on food intake
59. Peptides as drugs - better targeted
60. Rimonabant and oxyntomodulin are additive
61. Concluding remarks

Topics Covered

• Anti-obesity agents
• Bariatric surgery
• The gut hormones
• Ghrelin
• Energy intake free-choice meal
• Meal intake after Ghrelin infusion
• Why do you feel less hungry after a meal?
• Three types of satiety action
• Peptide YY (PYY)
• GI tract distribution of PYY
• Post-prandial secretion of PYY
• Effect of PYY on food intake
• Glucagon-like peptide 1
• The effect of chronic GLP-1 on body weight
• Oxyntomodulin
• Leptin change
• Human pancreatic polypeptide
• Peptides as drugs: better targeted

Links

Series:

• Obesity

Categories:

• Clinical Practice
• Metabolism & Nutrition

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Bloom, S. (2009, March 31). Gastrointestinal peptides and food intake regulation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/1149/.
Export Citation (RIS)

Publication History

• Published on March 31, 2009
• Archived on November 30, 2015

Financial Disclosures

• Prof. Sir Stephen Bloom, Grant/Research Support (Principal Investigator): Medical Research Council