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- Introduction to Cancer Therapy
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1. Early detection of lung cancer
- Prof. Stephen Lam
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2. Development of a cancer drug
- Prof. Martin Edelman
- Use of Novel "Targeted" Agents in Combination with Classical Cytotoxic Chemotherapy
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3. Cytotoxic chemotherapy
- Dr. Michael Sawyer
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4. Small molecule inhibitors of receptor tyrosine kinases
- Dr. Daniela Krause
- Innovative Strategies of Clinical Drug Development
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5. Phase II trials
- Dr. Patricia Tang
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6. Surrogate endpoints of efficacy
- Prof. Maurie Markman
- Biomarkers in Oncology: Rationale Development and Current Use
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7. Biomarkers in oncology: overview
- Prof. Joe Duffy
- Archived Lectures *These may not cover the latest advances in the field
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9. Emerging trends in phase II trial design
- Dr. Patricia Tang
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11. Therapy in cancer 2008: quo vadis?
- Dr. Jeffrey Clark
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13. Phase III trials
- Prof. Martin Edelman
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15. Gene profiling in breast cancer
- Dr. Enrique Espinosa
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18. Understanding cancer trends
- Prof. Michael Thun
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20. Phase I study design for non-cytotoxic agents
- Dr. Wendy Parulekar
Printable Handouts
Navigable Slide Index
- Introduction
- Talk outline
- Trends in cancer incidence or death rates
- Screening effect on prostate cancer incidence
- What to look for in interpreting cancer trends
- Distinguishing between rates and numbers
- Overall death rate from cancer decreased by 17%
- U.S. population age distribution, 2000, 2025, 2050
- The number of cases or deaths may increase
- The future without prevention
- Both death rate and number of cases are important
- Cost projections
- Interpreting cancer trends (1)
- Defining incidence, mortality & relative survival
- Cancer death rates: all sites combined by sex
- Cancer incidence rates: all sites combined by sex
- 5-year relative survival: all sites combined by sex
- Incidence and mortality are affected differently
- Prevention, screening, and treatment
- Interpreting cancer trends (2)
- Cancer death rates among men
- Cancer death rates among women
- The trend in all cancers combined
- 2008 estimated US cancer cases
- Men cancer sites with decreasing death rates
- Women cancer sites with decreasing death rates
- Men cancer sites with decreasing incidence rates
- Women cancers with decreasing incidence rates
- Man increasing or not decreasing incidence rates
- Increasing or not decreasing incidence rates
- Increasing or not decreasing mortality rates
- Substantial progress is being made
- Number of cancer deaths avoided
- Lung cancer deaths prevented
- Prevention gains are hard-won
- Further progress needed in early detection
- Proper Triage
- Multiple ways to reduce the burden of cancer
- Conclusions
- Progress can be sustained and accelerated by
- Acknowledgements
- Thank you
Topics Covered
- Current trends in cancer incidence, mortality and relative survival in the US
- Understanding how improvements in prevention, early detection and treatment affect these trends
- How demographic changes affect the number of cancer cases and deaths but not the age-standardized incidence or death rates
- Specific cancer sites for which the incidence and/or death rates are changing
- Role of prevention, early detection, and improvements in treatment in reducing the burden of cancer
Talk Citation
Thun, M. (2009, January 6). Understanding cancer trends [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 24, 2024, from https://hstalks.com/bs/1109/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Michael Thun has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.