• Epidemiology and Risk Factors
• 23 min
  1. Coronary heart disease epidemiology: global context for a new genetic understanding

  • Prof. Harry Hemingway
• 44 min
  2. Cardiovascular risk factors

  • Dr. Michal Vrablik
• 29 min
  3. Lipid metabolism

  • Dr. Ulrike Beisiegel
• 39 min
  4. Thrombotic risk factors for cardiovascular disease

  • Prof. Gordon Lowe
• Biology of Coronary Heart Disease
• 42 min
  5. Plaque rupture

  • Prof. Petri Kovanen
• 56 min
  6. Transcription factors and complex disease development

  • Dr. Ines Pineda-Torra
• 39 min
  7. Animal models to explore cardiovascular disease

  • Prof. Martin Merkel
• Treatment
• 26 min
  8. Diagnosis and treatment of dyslipidemias

  • Prof. Anton Stalenhoef
• 31 min
  9. Key drug discovery challenges in cardiovascular medicine

  • Dr. Dan Swerdlow
  • Dr. Michael V. Holmes
• Genetics
• 50 min
  10. Moving from GWAS hits to functional variants

  • Prof. Steve Humphries
• 51 min
  11. Heart disease genes and SNPs

  • Prof. Steve Humphries
• 39 min
  12. Familial hypercholesterolaemia: genetic causes and treatment

  • Prof. Steve Humphries
• 22 min
  13. Familial hypercholesterolaemia: cascade testing and monogenic vs. polygenic causes

  • Prof. Steve Humphries
• 28 min
  14. Familial hypercholesterolaemia: case studies, universal screening and novel mutations

  • Prof. Steve Humphries
• 52 min
  15. Genetics of cardiovascular disease

  • Prof. Philippa Talmud
• 35 min
  16. Mendelian randomisation: using genetics to determine causality

  • Dr. Tina Shah
• 33 min
  17. The genetics of abdominal aortic aneurysm

  • Dr. Seamus Harrison
• 49 min
  18. Genome scans for hypertension

  • Prof. Patricia Munroe
• 43 min
  19. Telomeres and cardiovascular disease

  • Dr. Jess Buxton
• 33 min
  20. Translational applications of cardiovascular genomics: opportunities and challenges

  • Dr. Aroon Hingorani
• Archived Lectures *These may not cover the latest advances in the field
• 44 min
  21. Gene-environment interaction and oxidative stress in cardiovascular disease

  • Dr. Jeffrey Stephens
• 34 min
  22. Gene therapy as a therapeutic option for lipoprotein lipase deficiency

  • Dr. Jan Albert Kuivenhoven
• 60 min
  23. Cardiovascular diseases: from epidemiology to nutritional interventions

  • Dr. Antonis Zampelas
• 45 min
  24. Genetic testing for CHD risk: fact or fiction?

  • Prof. Steve Humphries
• 35 min
  25. Pharmacogenetics: progress, pitfalls and clinical potential

  • Prof. Steve Humphries
• 50 min
  26. Familial hyperchlolesterolaemia: a monogenic cause of early CHD

  • Prof. Steve Humphries

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Lipids
3. Functions of lipids
4. Outline (1)
5. Lipid absorption in the intestine
6. Intestinal sterol uptake
7. Intestinal fatty acid uptake
8. Intestinal chylomicron formation
9. Postprandial hyperlipidemia
10. Lipoprotein model
11. Major lipoproteins and apoproteins
12. Apo B100 and Apo B48 are derived from one gene
13. Postprandial lipoprotein metabolism
14. Insulin as a major postprandial hormone
15. Metabolism of adipose tissue
16. Nutritional lipids are also delivered to the bone
17. CR deliver lipids and vitamin K to the bone
18. Outline (2)
19. Hepatic lipid metabolism
20. Hepatic receptors for lipoprotein uptake
21. CR uptake into the liver
22. Hepatic lipoprotein pathways
23. Size of VLDL determines LDL size
24. Role of apo E in lipoprotein catabolism
25. Apo E polymorphism
26. Outline (3)
27. LDL receptor a key player in cellular homeostasis
28. Intracellular cholesterol regulated gene expression
29. Outline (4)
30. Reverse cholesterol transport by HDL
31. Lipid exchange proteins
32. Normal levels for plasmalipids
33. Dietary lipids
34. Thank you

Topics Covered

• Functions of lipids
• Lipid absorption in the intestine
• Intestinal sterol and fatty acid uptake
• Intestinal chylomicron formation
• Postprandial hyperlipidemia
• Lipoprotein model
• Major lipoproteins and apoproteins
• Postprandial lipoprotein metabolism
• Insulin as major postprandial hormone
• Metabolism of adipose tissue
• Nutritional lipids are also delivered to the bone
• Chylomicron remnants deliver lipids and vitamin K to the bone
• Hepatic lipid metabolism
• What are the receptors responsible for CR uptake?
• CR uptake into the liver
• Hepatic lipoprotein pathways
• Size of VLDL determines LDL size
• Role of apo E in lipoprotein catabolism
• Apo E polymorphism
• Cellular cholesterol homeostasis
• LDL receptor involved in cellular cholesterol homeostasis
• Intracellular cholesterol regulated gene expression
• 'Reverse cholesterol transport' by HDL
• Lipid exchange proteins
• Normal levels for plasmalipids
• Dietary lipids

Links

Series:

• Genetics of Cardiovascular Disease

Categories:

• Clinical Practice

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on December 15, 2008

Financial Disclosures

• Dr. Ulrike Beisiegel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.