https://hstalks.com/category/754/pharmaceutical-sciences/?biosci New and updated series & talks on Pharmaceutical Sciences from HSTalks' Biomedical & Life Sciences Collection. daily 1 2006-01-01T12:00+00:00 Henry Stewart Talks en © Copyright Henry Stewart Talks Ltd. The Biomedical & Life Sciences Collection © Copyright Henry Stewart Talks Ltd. https://hstalks.com/t/21778/cholesterol-biosynthesis-and-statins/?biosci Cholesterol biosynthesis pathway - Regulation of hepatic cholesterol - Statin mechanism of action - Statin clinical uses and benefits - Statin side effects and monitoring Cholesterol biosynthesis and statins Cholesterol biosynthesis pathway, Regulation of hepatic cholesterol, Statin mechanism of action, Statin clinical uses and benefits, Statin side effects and monitoring 2026-05-28 2026-05-28 The Biomedical & Life Sciences Collection https://hstalks.com/t/18275/pediatric-research-technical-logistical-considerat/?biosci Pediatric research rationale - American Academy of Pediatrics guidelines (1995) - ADME summary - Post natal ontogeny: Additional dynamics - Post natal ontogeny medicinal product dosing implications - Dosing approaches - Body surface and weight-based dosing - Age-based dosing: Approximations that require careful monitoring - General pediatric dosing considerations - Dosage forms Pediatric research: technical & logistical considerations - post natal ontogeny Prof. Steven Hirschfeld Pediatric research rationale, American Academy of Pediatrics guidelines (1995), ADME summary, Post natal ontogeny: Additional dynamics, Post natal ontogeny medicinal product dosing implications, Dosing approaches, Body surface and weight-based dosing, Age-based dosing: Approximations that require careful monitoring, General pediatric dosing considerations, Dosage forms 2026-05-28 2026-05-28 The Biomedical & Life Sciences Collection https://hstalks.com/t/21774/pharmaceutical-biotechnology/?biosci Pharmaceutical biotech advances - Biologic drug development - Large-scale production breakthroughs - Biologic manufacturing complexities - Biologic stability and immune challenges - Biosimilars and gene editing solutions - Regulatory landscape and impact Pharmaceutical biotechnology Pharmaceutical biotech advances, Biologic drug development, Large-scale production breakthroughs, Biologic manufacturing complexities, Biologic stability and immune challenges, Biosimilars and gene editing solutions, Regulatory landscape and impact 2026-05-28 2026-05-28 The Biomedical & Life Sciences Collection https://hstalks.com/t/21096/kalihinol-analog-med6-189-a-promising-pan-antimala/?biosci Antimalarial drug discovery - Natural product analogues (Kalinol) - Drug-resistant Plasmodium falciparum - Mechanism of action studies - Apicoplast targeting - Vesicular trafficking pathways - Semi-synthetic compound (MED6-189) - Preclinical development and translational challenges Kalihinol analog MED6-189: a promising pan-antimalarial candidate Prof. Karine Le Roch Antimalarial drug discovery, Natural product analogues (Kalinol), Drug-resistant Plasmodium falciparum, Mechanism of action studies, Apicoplast targeting, Vesicular trafficking pathways, Semi-synthetic compound (MED6-189), Preclinical development and translational challenges 2026-05-28 2026-05-28 The Biomedical & Life Sciences Collection https://hstalks.com/t/21051/pharmacology-in-pregnancy/?biosci Pharmacology in pregnancy - Drug metabolism in pregnancy - Placental drug transfer - Medication choices in pregnancy - Chronic illness management in pregnancy - Medication safety in breastfeeding - Risk assessment and clinical resources Pharmacology in pregnancy Pharmacology in pregnancy, Drug metabolism in pregnancy, Placental drug transfer, Medication choices in pregnancy, Chronic illness management in pregnancy, Medication safety in breastfeeding, Risk assessment and clinical resources 2026-04-30 2026-04-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/20485/drug-regulation-recent-advancements-2026/?biosci Drug regulation - Real-world evidence - Adaptive approvals - Clinical trials (decentralised) - AI & digital health - Patient-centred outcomes - Regulatory harmonisation - Access to medicines Drug regulation: recent advancements (2026) Dr. Assem El Baghdady Drug regulation, Real-world evidence, Adaptive approvals, Clinical trials (decentralised), AI & digital health, Patient-centred outcomes, Regulatory harmonisation, Access to medicines 2026-04-30 2026-04-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/20980/drug-calculations-for-healthcare/?biosci Accurate drug calculations - Unit conversions & metrics - Interpreting med labels - Oral & IV dose determination - Dosing adjustments for populations - Drug dosing formulas - Five rights of medication - Drug absorption & metabolism factors Drug calculations for healthcare Accurate drug calculations, Unit conversions & metrics, Interpreting med labels, Oral & IV dose determination, Dosing adjustments for populations, Drug dosing formulas, Five rights of medication, Drug absorption & metabolism factors 2026-04-30 2026-04-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/18307/ich-s8-immune-system-toxicity/?biosci The human immune system - Adaptive and innate immunity - Immunotoxicology of human pharmaceuticals - ICH immunotoxicity database - Guideline ICH S8 - Weight-of-evidence review - Immunotoxicity factors to be considered - Immunotoxicity evaluation ICH S8 immune system toxicity Dr. Jan Willem van der Laan The human immune system, Adaptive and innate immunity, Immunotoxicology of human pharmaceuticals, ICH immunotoxicity database, Guideline ICH S8, Weight-of-evidence review, Immunotoxicity factors to be considered, Immunotoxicity evaluation 2026-04-30 2026-04-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/17911/generative-ai-in-drug-development-balancing-innova/?biosci Artificial intelligence (AI) - Generative AI - Databases used by AI - AI role in drug discovery and development - AI market - Can generative AI catchup with brain? Generative AI in drug development: balancing innovation with human insight Prof. Sarfaraz K. Niazi Artificial intelligence (AI), Generative AI, Databases used by AI, AI role in drug discovery and development, AI market, Can generative AI catchup with brain? 2026-04-30 2026-04-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/20981/analgesics/?biosci Analgesics overview and medical use - Analgesic types and mechanisms - Opioid vs non-opioid analgesics - Indications, contraindications, side effects - Analgesic administration routes - Personalized multimodal pain management - Non-drug pain management approaches Analgesics Analgesics overview and medical use, Analgesic types and mechanisms, Opioid vs non-opioid analgesics, Indications, contraindications, side effects, Analgesic administration routes, Personalized multimodal pain management, Non-drug pain management approaches 2026-04-30 2026-04-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/17416/intellectual-property-and-patents/?biosci Drug patent - Intellectual property rules and regulations - Drug development costs - IP protection period - Drug development economics - Patent suitability - Patent transfer Intellectual property and patents Dr. Wayne Carter Drug patent, Intellectual property rules and regulations, Drug development costs, IP protection period, Drug development economics, Patent suitability, Patent transfer 2026-04-30 2026-04-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/18043/ich-10-photosafety-evaluation-of-pharmaceuticals/?biosci Phototoxicity - ICH S10 guideline - Factors considered in phototoxicity assessment - Nonclinical photosafety assessment - Human data in photosafety testing ICH 10 photosafety evaluation of pharmaceuticals Dr. David R. Jones Phototoxicity, ICH S10 guideline, Factors considered in phototoxicity assessment, Nonclinical photosafety assessment, Human data in photosafety testing 2026-04-30 2026-04-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/21053/enzymes-in-drug-metabolism/?biosci Role of enzymes in drug metabolism - Phases of drug metabolism - Cytochrome P450 enzyme functions - Conjugating enzymes in Phase Two - Influences on enzyme activity - Enzyme induction and inhibition - Pharmacogenomics in personalized medicine Enzymes in drug metabolism Role of enzymes in drug metabolism, Phases of drug metabolism, Cytochrome P450 enzyme functions, Conjugating enzymes in Phase Two, Influences on enzyme activity, Enzyme induction and inhibition, Pharmacogenomics in personalized medicine 2026-04-30 2026-04-30 The Biomedical & Life Sciences Collection https://hstalks.com/playlist/1941/regulatory-ich-guidelines-with-nonclinical-impact/?biosci M4 Common Technical Dossier - M3 Nonclinical Requirements for Clinical Trials, First-in-Human - S1A/C Carcinogenicity Studies: When are they Needed/ Dose Selection - S1B Testing Carcinogenic Potential of Human Pharmaceuticals, Transgenic Models - S6 Preclinical Requirements for Biotechnology-derived Products - S7 Safety Pharmacology - S8 Immunotoxicity - S11 Juvenile Toxicity Testing - 1B(R1) Testing Carcinogenic Potential of Human Pharmaceuticals Approach - S2 Genotoxicity - S3 Pharmacokinetics - S4 Chronic Toxicity- S5 Reproductive Toxicity Testing - S9 Testing of anticancer compounds - S10 Photosafety - S12 Nonclinical Safety Testing of Gene Therapy Regulatory ICH Guidelines with Nonclinical Impact Dr. Jan Willem van der Laan M4 Common Technical Dossier, M3 Nonclinical Requirements for Clinical Trials, First-in-Human, S1A/C Carcinogenicity Studies: When are they Needed/ Dose Selection, S1B Testing Carcinogenic Potential of Human Pharmaceuticals, Transgenic Models, S6 Preclinical Requirements for Biotechnology-derived Products, S7 Safety Pharmacology, S8 Immunotoxicity, S11 Juvenile Toxicity Testing, 1B(R1) Testing Carcinogenic Potential of Human Pharmaceuticals Approach, S2 Genotoxicity, S3 Pharmacokinetics, S4 Chronic Toxicity- S5 Reproductive Toxicity Testing, S9 Testing of anticancer compounds, S10 Photosafety, S12 Nonclinical Safety Testing of Gene Therapy 2026-03-31 2026-03-31 The Biomedical & Life Sciences Collection https://hstalks.com/t/16888/use-of-cholera-vaccine-in-bangladesh-success-and-s/?biosci Cholera vaccination stats of Bangladesh - Vaccine research and development for cholera in Bangladesh - Bangladesh cholera vaccination for Rohingya refugees - Cholera sources - Cholera prevention - Cholera strains Use of cholera vaccine in Bangladesh: success and struggles Dr. Firdausi Qadri Cholera vaccination stats of Bangladesh, Vaccine research and development for cholera in Bangladesh, Bangladesh cholera vaccination for Rohingya refugees, Cholera sources, Cholera prevention, Cholera strains 2026-03-31 2026-03-31 The Biomedical & Life Sciences Collection https://hstalks.com/t/19860/receptor-types-and-drug-targets/?biosci Receptor types and classes - Drug-receptor interaction mechanisms - Major drug targets - Target selectivity and side effects - Roles of agonists, antagonists, modulators - Genetic variability in personalized medicine Receptor types and drug targets Receptor types and classes, Drug-receptor interaction mechanisms, Major drug targets, Target selectivity and side effects, Roles of agonists, antagonists, modulators, Genetic variability in personalized medicine 2026-03-31 2026-03-31 The Biomedical & Life Sciences Collection https://hstalks.com/t/17614/m4-common-technical-dossier/?biosci CTD triangle - Nonclinical overview - Nonclinical written summaries - Assessment reports - Appendices M4 common technical dossier Dr. Jan Willem van der Laan CTD triangle, Nonclinical overview, Nonclinical written summaries, Assessment reports, Appendices 2026-03-31 2026-03-31 The Biomedical & Life Sciences Collection https://hstalks.com/t/17086/ich-s3a-and-s3b-toxicokinetics-and-pharmacokinetic/?biosci ICH establishment & guidelines - Pharmacokinetics - Toxicokinetics - Microsampling ICH S3A and S3B toxicokinetics and pharmacokinetics Dr. David R. Jones ICH establishment & guidelines, Pharmacokinetics, Toxicokinetics, Microsampling 2026-03-31 2026-03-31 The Biomedical & Life Sciences Collection https://hstalks.com/t/16690/muscarinic-acetylcholine-receptor-modulation-in-ne/?biosci Muscarinic acetylcholine receptors - Neurological drug discovery - Schizophrenia and Alzheimer’s disease - Structure-based drug design - Allosteric GPCR modulation Muscarinic acetylcholine receptor modulation in neurological diseases Prof. Andrew B. Tobin Muscarinic acetylcholine receptors, Neurological drug discovery, Schizophrenia and Alzheimer’s disease, Structure-based drug design, Allosteric GPCR modulation 2026-03-31 2026-03-31 The Biomedical & Life Sciences Collection https://hstalks.com/t/17251/advanced-therapies-in-an-evolving-regulatory-and-a/?biosci Pharma legislation - ATMPs situation in EU - Role of academia in development of advanced therapies - Strategies for translating therapies from Idea to Patient Care - Manufacturing Do’s and Don’ts Advanced therapies in an evolving regulatory and access environment Dr. Ana Hidalgo-Simon Pharma legislation, ATMPs situation in EU, Role of academia in development of advanced therapies, Strategies for translating therapies from Idea to Patient Care, Manufacturing Do’s and Don’ts 2026-03-31 2026-03-31 The Biomedical & Life Sciences Collection https://hstalks.com/t/18241/nonclinical-safety-testing-of-human-pharmaceutical/?biosci ICH participants and ICH safety topics - Benefit-risk assessment - ICH M3: Mother of all guidelines - Guidance history on first-in-human (FIH) starting dose - ICH S7A: Safety pharmacology studies - S7B: Non-clinical testing strategy - Genotoxicity testing - ICH S4: Single and repeated dose toxicity studies Nonclinical safety testing of human pharmaceuticals in relation to clinical development Dr. Jan Willem van der Laan ICH participants and ICH safety topics, Benefit-risk assessment, ICH M3: Mother of all guidelines, Guidance history on first-in-human (FIH) starting dose, ICH S7A: Safety pharmacology studies, S7B: Non-clinical testing strategy, Genotoxicity testing, ICH S4: Single and repeated dose toxicity studies 2026-03-31 2026-03-31 The Biomedical & Life Sciences Collection