https://hstalks.com/biosci/ New and updated series & talks from HSTalks' Biomedical & Life Sciences Collection. daily 1 2006-01-01T12:00+00:00 Henry Stewart Talks en © Copyright Henry Stewart Talks Ltd. The Biomedical & Life Sciences Collection © Copyright Henry Stewart Talks Ltd. https://hstalks.com/t/27031/drug-modality-selection/?biosci Drug modality selection - Types of drug modalities - Modality advantages and challenges - Delivery and stability - Matching modalities to disease - Practical considerations for modalities - Modality limitations and constraints Drug modality selection Drug modality selection, Types of drug modalities, Modality advantages and challenges, Delivery and stability, Matching modalities to disease, Practical considerations for modalities, Modality limitations and constraints 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/27030/safety-signal-detection/?biosci Safety signal detection - Preclinical safety assessment - Clinical safety monitoring - Post-marketing pharmacovigilance - Adverse reaction methodologies - Data quality challenges - Regulatory safety responses Safety signal detection Safety signal detection, Preclinical safety assessment, Clinical safety monitoring, Post-marketing pharmacovigilance, Adverse reaction methodologies, Data quality challenges, Regulatory safety responses 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/27025/dose-response-relationships/?biosci Dose-response basics - Emax model applications - Potency vs efficacy - Therapeutic window & optimization - Patient variability in dosing - Dose-response in early trials - Drug monitoring & personalized dosing Dose-response relationships Dose-response basics, Emax model applications, Potency vs efficacy, Therapeutic window & optimization, Patient variability in dosing, Dose-response in early trials, Drug monitoring & personalized dosing 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/27024/hit-to-lead-process/?biosci Hit-to-Lead stages - Screening and hit ID - Hit triage and criteria - SAR studies - Early ADMET - Scientific disciplines and risk - Technologies in hit-to-lead Hit-to-lead process Hit-to-Lead stages, Screening and hit ID, Hit triage and criteria, SAR studies, Early ADMET, Scientific disciplines and risk, Technologies in hit-to-lead 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/27028/therapeutic-window-and-safety-margins/?biosci Therapeutic window and index - Effective vs toxic dose - Patient factors in drug response - Dosing decisions and monitoring - Narrow therapeutic index drugs Therapeutic window and safety margins Therapeutic window and index, Effective vs toxic dose, Patient factors in drug response, Dosing decisions and monitoring, Narrow therapeutic index drugs 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/27029/biomarker-development-and-application/?biosci Biomarker discovery with omics - Data integration with clinical info - Analytical and clinical validation - Types and roles of biomarkers - Biomarkers in precision medicine - Regulatory pathways for biomarkers - Cross-disciplinary collaboration in biomarker development Biomarker development and application Biomarker discovery with omics, Data integration with clinical info, Analytical and clinical validation, Types and roles of biomarkers, Biomarkers in precision medicine, Regulatory pathways for biomarkers, Cross-disciplinary collaboration in biomarker development 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/27020/adaptive-clinical-trial-designs/?biosci Adaptive Clinical Trials - Interim Analyses - Response-Adaptive Randomisation - Statistical Error Control - Regulatory Requirements - Advantages Over Fixed Designs - Operational Planning Adaptive clinical trial designs Adaptive Clinical Trials, Interim Analyses, Response-Adaptive Randomisation, Statistical Error Control, Regulatory Requirements, Advantages Over Fixed Designs, Operational Planning 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/26062/newborn-screening-how-genome-sequencing-is-changin/?biosci Genome sequencing - Newborn screening - Whole-genome sequencing - Genetic disorders - Immunodeficiency - Health equity - Genomic data interpretation - Population health Newborn screening: how genome sequencing is changing early diagnosis Dr. Wendy Chung Genome sequencing, Newborn screening, Whole-genome sequencing, Genetic disorders, Immunodeficiency, Health equity, Genomic data interpretation, Population health 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/27021/patient-recruitment-and-retention/?biosci Patient recruitment and retention - Barriers to recruitment - Inclusion and exclusion criteria - Strategies for retention and engagement - Diversity and equity in research - Ethical considerations in recruitment - Decentralized and patient-centric trials Patient recruitment and retention Patient recruitment and retention, Barriers to recruitment, Inclusion and exclusion criteria, Strategies for retention and engagement, Diversity and equity in research, Ethical considerations in recruitment, Decentralized and patient-centric trials 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/27023/drug-target-landscape/?biosci Drug target classification - Drug-target interaction mechanisms - Druggability assessment - Drug-target engagement examples - Advances in drug target discovery Drug target landscape Drug target classification, Drug-target interaction mechanisms, Druggability assessment, Drug-target engagement examples, Advances in drug target discovery 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/27027/pharmacodynamics-vs-pharmacokinetics/?biosci Pharmacokinetics vs Pharmacodynamics - ADME processes - Drug interactions with targets - Dose-response relationships - Integration of PK/PD in therapy - PK/PD modeling - Individualized and evidence-based prescribing Pharmacodynamics vs pharmacokinetics Pharmacokinetics vs Pharmacodynamics, ADME processes, Drug interactions with targets, Dose-response relationships, Integration of PK/PD in therapy, PK/PD modeling, Individualized and evidence-based prescribing 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/22631/phosphorus/?biosci Functions in the body - Food sources - Absorption - Metabolism - Deficiency - Excess intake - Dietary reference values of phosphorus for adults Phosphorus Prof. Susan Fairweather-Tait Functions in the body, Food sources, Absorption, Metabolism, Deficiency, Excess intake, Dietary reference values of phosphorus for adults 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/22267/itch-vs-pain/?biosci Pain mediators and receptors - Pruritus in humans and animals - Itch mediators and receptors - Pain and itch pathway - Coding theories of pain and itch - Drug induced pain and itch - Cutaneous T-cell lymphoma (CTCL) with chronic itch - Neuro-glial interactions in chronic pain - Translational revolution of itch Itch vs. pain Prof. Ru-Rong Ji Pain mediators and receptors, Pruritus in humans and animals, Itch mediators and receptors, Pain and itch pathway, Coding theories of pain and itch, Drug induced pain and itch, Cutaneous T-cell lymphoma (CTCL) with chronic itch, Neuro-glial interactions in chronic pain, Translational revolution of itch 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/20188/zinc/?biosci Zinc function in the body - Food sources of zinc - Absorption and bioavailability of zinc - Zinc homeostasis - Deficiency and excess of zinc - Acrodermatitis enteropathica - Dietary reference values for adult men and pre-menopausal women Zinc Prof. Susan Fairweather-Tait Zinc function in the body, Food sources of zinc, Absorption and bioavailability of zinc, Zinc homeostasis, Deficiency and excess of zinc, Acrodermatitis enteropathica, Dietary reference values for adult men and pre-menopausal women 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/23257/cobalamin-vitamin-b12/?biosci Functions of vitamin B12 in the body - Food sources of vitamin B12 - Absorption and metabolism - Deficiency and excess of vitamin B12 - Dietary reference values for vitamin B12 for adults Cobalamin (vitamin B12) Prof. Susan Fairweather-Tait Functions of vitamin B12 in the body, Food sources of vitamin B12, Absorption and metabolism, Deficiency and excess of vitamin B12, Dietary reference values for vitamin B12 for adults 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/27019/clinical-trial-endpoints/?biosci Role of trial endpoints - Types of trial endpoints - Pre-specification of endpoints - Surrogate endpoints use and validation - Statistical vs clinical significance - Endpoint selection impact - Regulatory requirements for endpoints Clinical trial endpoints Role of trial endpoints, Types of trial endpoints, Pre-specification of endpoints, Surrogate endpoints use and validation, Statistical vs clinical significance, Endpoint selection impact, Regulatory requirements for endpoints 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/22202/us-privacy-law-and-digital-therapeutics/?biosci Digital Therapeutics - Digital Health - Virtual Care - US FDA - HIPAA - Privacy - Security - US FTC U.S. privacy law and digital therapeutics Ms. Lucia C. Savage Digital Therapeutics, Digital Health, Virtual Care, US FDA, HIPAA, Privacy, Security, US FTC 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/25633/lariocidin-a-novel-antibiotic-that-disrupts-bacter/?biosci Laryosidin - Novel antibiotic discovery - Bacterial ribosome - Antimicrobial resistance - Ribosome-targeting antibiotics - Lassopeptides - Antibiotic biosynthesis - Clinical antibiotic development Lariocidin: a novel antibiotic that disrupts bacterial protein synthesis Prof. Gerry Wright Laryosidin, Novel antibiotic discovery, Bacterial ribosome, Antimicrobial resistance, Ribosome-targeting antibiotics, Lassopeptides, Antibiotic biosynthesis, Clinical antibiotic development 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/26458/the-case-of-an-asymptomatic-alzheimers-mutation-ca/?biosci Familial Alzheimer’s disease - PSEN1 mutation - Amyloid deposition - Tau pathology - Genetic resilience - Heat shock proteins - Tau-targeted therapies - Precision medicine The case of an asymptomatic Alzheimer’s mutation carrier Dr. Jorge J. Llibre-Guerra Familial Alzheimer’s disease, PSEN1 mutation, Amyloid deposition, Tau pathology, Genetic resilience, Heat shock proteins, Tau-targeted therapies, Precision medicine 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/23059/risdiplam-for-prenatal-therapy-of-spinal-muscular-/?biosci Spinal muscular atrophy (SMA) - Prenatal therapy - Fetal medicine - Risdiplam - SMN2 splicing modulation - Genetic disorders - Pediatric neurology - Translational medicine - Rare diseases - In utero treatment Risdiplam for prenatal therapy of spinal muscular atrophy Dr. Richard Finkel Spinal muscular atrophy (SMA), Prenatal therapy, Fetal medicine, Risdiplam, SMN2 splicing modulation, Genetic disorders, Pediatric neurology, Translational medicine, Rare diseases, In utero treatment 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/22102/walking-on-water-load-bearing-joint-perfusion-and-/?biosci Joints - IOP measurement - Factor affecting IOP measurements - Significance of IOPv - IOPa - Load - Vascular markings in MRI scans - Correlation between vascular marks and Kellgren - Lawrence grade - Bone histology - Choke valve Walking on water: load bearing, joint perfusion and osteoarthritis Dr. Michael Beverly Joints, IOP measurement, Factor affecting IOP measurements, Significance of IOPv, IOPa, Load, Vascular markings in MRI scans, Correlation between vascular marks and Kellgren, Lawrence grade, Bone histology, Choke valve 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/27022/target-identification-in-practice/?biosci Target ID principles & importance - Omics & computational advances - Data-driven disease profiling - Functional validation: RNAi & CRISPR - Pathway & systems biology integration - Rigorous target validation strategies Target identification in practice Target ID principles & importance, Omics & computational advances, Data-driven disease profiling, Functional validation: RNAi & CRISPR, Pathway & systems biology integration, Rigorous target validation strategies 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/22696/digital-health-technologies-dhts-for-drug-developm/?biosci Digital health technologies - CNS - Parkinson’s disease - WATCH PD - Critical Path Institute - Rare neurodegenerative disease - Public private partnership model Digital health technologies (DHTs) for drug development in CNS diseases Dr. Diane T. Stephenson Digital health technologies, CNS, Parkinson’s disease, WATCH PD, Critical Path Institute, Rare neurodegenerative disease, Public private partnership model 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/27026/receptor-theory-in-pharmacology/?biosci Receptor-ligand binding - Agonists vs antagonists - Allosteric modulation - Affinity and specificity - Receptor occupancy theory - Clinical drug examples - Receptor theory in drug development Receptor theory in pharmacology Receptor-ligand binding, Agonists vs antagonists, Allosteric modulation, Affinity and specificity, Receptor occupancy theory, Clinical drug examples, Receptor theory in drug development 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/22366/routine-growth-screening-does-it-measure-up-2/?biosci Case studies - Numbers behind the growth curve - Hydrocephalus - Growth curves - Limitations to growth screening Routine growth screening: does it measure up? 2 Prof. Natasha Shur Case studies, Numbers behind the growth curve, Hydrocephalus, Growth curves, Limitations to growth screening 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/22071/routine-growth-screening-does-it-measure-up-1/?biosci Pediatric care - Brief history of screening growth - Routine growth screening - CDC versus WHO - Growth curves Routine growth screening: does it measure up? 1 Prof. Natasha Shur Pediatric care, Brief history of screening growth, Routine growth screening, CDC versus WHO, Growth curves 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/22432/growth-screening-and-rare-disease/?biosci Importance and limitations of routine growth testing - Rare disease specific growth curves - Prader Willi Syndrome (PWS) - Future of routine growth screening - Pediatric genetic testing Growth screening and rare disease Prof. Natasha Shur Importance and limitations of routine growth testing, Rare disease specific growth curves, Prader Willi Syndrome (PWS), Future of routine growth screening, Pediatric genetic testing 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/27044/applications-of-cell-culture-in-drug-development/?biosci Cell culture fundamentals - Cell culture requirements - Cell line types in research - Cell culture in drug development - Drug screening using cell culture - Limitations of cell culture models Applications of cell culture in drug development Cell culture fundamentals, Cell culture requirements, Cell line types in research, Cell culture in drug development, Drug screening using cell culture, Limitations of cell culture models 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/22729/biomedicines-extraordinary-opportunities-amidst-un/?biosci Evolution of the FDA - Eroom’s law - Blockbuster and me-too drugs - Eli Lilly as an innovator - Impact of mergers on biomedicine research - Industry consolidation and its impact - Impact of academia on biomedicines Biomedicines: extraordinary opportunities amidst uncertain times Prof. Michael Kinch Evolution of the FDA, Eroom’s law, Blockbuster and me-too drugs, Eli Lilly as an innovator, Impact of mergers on biomedicine research, Industry consolidation and its impact, Impact of academia on biomedicines 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/22927/early-evolution-of-animals-a-paleontological-persp/?biosci Importance of fossils - Crown vs. stem groups -Holozoans - Ediacaran period - Bilaterians and sponges - Kimberella and Dickinsonia - Fossil embryos - Cryogenian and Tonian period Early evolution of animals: a paleontological perspective Prof. Shuhai Xiao Importance of fossils, Crown vs. stem groups -Holozoans, Ediacaran period, Bilaterians and sponges, Kimberella and Dickinsonia, Fossil embryos, Cryogenian and Tonian period 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/22333/ich-s12-nonclinical-biodistribution-considerations/?biosci Chapters of ICHS12 - Introduction (Objective and scope) - Definition of non-clinical (NC) biodistribution (BD) studies - Timing of BD studies - Design of BD studies - ICHS12: Specific considerations - Applications of BD studies ICH S12: nonclinical biodistribution considerations for gene therapy products Dr. Tineke van den Hoorn Chapters of ICHS12, Introduction (Objective and scope), Definition of non-clinical (NC) biodistribution (BD) studies, Timing of BD studies, Design of BD studies, ICHS12: Specific considerations, Applications of BD studies 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/t/27032/antibodies-vs-small-molecules/?biosci Antibody vs Small Molecule - Mechanisms & Pharmacokinetics - Drug Size Structure & Administration - Clinical Applications & Selection - Antibody vs Small Molecule Pros & Cons - Target Accessibility & Specificity - Innovations in Drug Development Antibodies vs small molecules Antibody vs Small Molecule, Mechanisms & Pharmacokinetics, Drug Size Structure & Administration, Clinical Applications & Selection, Antibody vs Small Molecule Pros & Cons, Target Accessibility & Specificity, Innovations in Drug Development 2026-09-30 2026-09-30 The Biomedical & Life Sciences Collection https://hstalks.com/playlist/1446/key-concepts-how-to-learn/?biosci Individual learning strategies - Note-taking - Generative AI and learning - Effective questioning - Critical thinking - Self-testing - Transfer of knowledge - Knowledge application - Interleaving - Learning Key Concepts: How to Learn Dr. Cynthia Nebel Individual learning strategies, Note-taking, Generative AI and learning, Effective questioning, Critical thinking, Self-testing, Transfer of knowledge, Knowledge application, Interleaving, Learning 2026-08-31 2026-08-31 The Biomedical & Life Sciences Collection https://hstalks.com/playlist/2139/the-lymphatic-system-in-health-and-disease/?biosci Lymphatic development, anatomy, and function - The Lymphatic System in CNS and Eye Health and Disease - Lymphatic dysfunction in cardiovascular diseases - Renal lymphatics: physiology and pathophysiological implications - Lymphatics and pulmonary function/disease - Gastrointestinal lymphatics: nutrient absorption, immunity, and disease - Lymphatic system dysfunction in obesity and metabolism - Lymphatic regulation of stem cell proliferation and differentiation in the GI tract and skin - The lymphatic system and autoimmunity - Lymphatic regulation of rheumatoid arthritis - Lymphedema: pathophysiology and clinical presentation - Inflammatory manifestations of lymphedema - Surgical treatment of lymphedema: current approaches and future directions - Lymphatic malformations and anomalies: Kaposiform lymphangiomatosis and Gorham-Stout disease - The lymphatic system and cancer: metastasis, tumor microenviornement, tumor immune responses - The lymphatic system as a therapeutic target in cancer - Lymphatic imaging in health and disease - Central lymphatic flow disorders: insights from new imaging modalities and new treatment options The Lymphatic System in Health and Disease Dr. Babak J. Mehrara Lymphatic development, anatomy, and function, The Lymphatic System in CNS and Eye Health and Disease, Lymphatic dysfunction in cardiovascular diseases, Renal lymphatics: physiology and pathophysiological implications, Lymphatics and pulmonary function/disease, Gastrointestinal lymphatics: nutrient absorption, immunity, and disease, Lymphatic system dysfunction in obesity and metabolism, Lymphatic regulation of stem cell proliferation and differentiation in the GI tract and skin, The lymphatic system and autoimmunity, Lymphatic regulation of rheumatoid arthritis, Lymphedema: pathophysiology and clinical presentation, Inflammatory manifestations of lymphedema, Surgical treatment of lymphedema: current approaches and future directions, Lymphatic malformations and anomalies: Kaposiform lymphangiomatosis and Gorham-Stout disease, The lymphatic system and cancer: metastasis, tumor microenviornement, tumor immune responses, The lymphatic system as a therapeutic target in cancer, Lymphatic imaging in health and disease, Central lymphatic flow disorders: insights from new imaging modalities and new treatment options 2026-07-30 2026-07-30 The Biomedical & Life Sciences Collection