• Diversity of Ion Channels
• 36 min
  1. The diversity and evolution of ion channels

  • Dr. Tim Jegla
• 52 min
  2. Alternative splicing and calcium ion channel diversity

  • Prof. Diane Lipscombe
• Ion Channel Structure and Function
• 21 min
  3. Functional modules in ion channels

  • Dr. Richard Horn
• 54 min
  4. Voltage-dependent gating of ion channels

  • Dr. Keith S. Elmslie
• 39 min
  5. M-current and its role in neuronal physiology

  • Prof. David A. Brown
• 50 min
  6. KATP channels and insulin secretion

  • Prof. Frances Mary Ashcroft
• Ion Channel Modulation
• 53 min
  7. Regulation of neuron accuracy by modulation of potassium channels

  • Prof. Leonard Kaczmarek
• 82 min
  8. Ion channel regulation by phosphorylation

  • Prof. Mike Shipston
• 43 min
  9. β2 adrenergic receptor complexes with Ca channels and AMPA receptors mediate localized cAMP signaling

  • Prof. Johannes Hell
• 29 min
  10. Calcium regulation of ion channels

  • Prof. Geoffrey S. Pitt
• Ion Channels and Neuronal Plasticity
• 48 min
  11. Modulation of intrinsic neuronal excitability 1

  • Prof. Nelson Spruston
• 45 min
  12. Modulation of intrinsic neuronal excitability 2

  • Prof. Nelson Spruston
• 33 min
  13. Glutamate receptor modulation and long-term synaptic plasticity

  • Prof. Graham Collingridge
• 44 min
  14. Cellular mechanisms of neuromodulation in a small neural network

  • Prof. Ronald M. Harris-Warrick
• Ion Channels and Disease
• 30 min
  15. Kv10.1 potassium channels in cancer

  • Prof. Luis Pardo
• 51 min
  16. Heritable arrhythmias: insight into molecular physiology from the long QT syndrome

  • Prof. Robert Kass
• Archived Lectures *These may not cover the latest advances in the field
• 43 min
  17. KV10.1 potassium channels in cancer

  • Prof. Luis Pardo

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. What are ion channels?
3. All physiological processes require ion channels
4. Ion channels are selective
5. Channels are gated
6. Voltage gating
7. Ligand gating
8. Sensory gating
9. Phototransduction relies on ligand-gated channels
10. Ion channels in the human genome
11. Channels vs. transporters
12. Highlights of the human channel set
13. Four-fold symmetric ion channels
14. Ion channels with other symmetry
15. Subunit topology and arrangement
16. A fundamental set of eumetazoan ion channels
17. The voltage-gated cation channel superfamily
18. Evolution of the nervous system
19. Prokaryotes
20. Choanoflagellates (1)
21. Choanoflagellates (2)
22. Sponge
23. Cnidarians have it all
24. What are Cnidarians doing with all channels?
25. Mammalian channel genes
26. Evolution of mammalian GABA-A receptors
27. Summary
28. New ion channels waiting to be discovered
29. Acknowledgements

Topics Covered

• What are ion channels and why are they important?
• Ion channels have diverse selectivity and gating
• Human channel diversity and structures
• A fundamental set of ion channels in animals
• How our voltage-gated ion channels evolved
• How are our ion channel gene families made?

Links

Series:

• Ion Channels

Categories:

• Biochemistry
• Genetics & Epigenetics

Talk Citation

Publication History

• Published on February 28, 2011

Financial Disclosures

• Dr. Tim Jegla has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.