• Special Designs
• 46 min
  1. Family-based association tests: introduction

  • Dr. Christoph Lange
• 29 min
  2. Family-based association tests: FBAT testing strategies for large-scale association studies

  • Dr. Christoph Lange
• 37 min
  3. Two-stage genome-wide association designs

  • Dr. Andrew Skol
• Special Populations
• 40 min
  4. Admixture mapping

  • Dr. Paul McKeigue
• Whole-Genome Studies: Types of Data
• 34 min
  5. QTL association mapping

  • Prof. Bruce Weir
• 50 min
  6. Adjusting for population structure in genetic association studies

  • Prof. David Balding
• Whole-Genome Studies 2: Methods
• 47 min
  7. Whole-genome association studies: practical advice and considerations

  • Dr. Mike Weale
• Archived Lectures *These may not cover the latest advances in the field
• 49 min
  8. Family-based association tests: FBATs for various data types

  • Dr. Christoph Lange
• 44 min
  9. Choosing between family-based and population-based association designs

  • Dr. Ren-Hua Chung
• 54 min
  10. Use of isolated populations: pitfalls and potential

  • Dr. Leena Peltonen
• 40 min
  11. Information on untyped variation in genome-wide association studies

  • Dr. Dan Nicolae
• 37 min
  12. Detecting multiple associations in genome-wide studies

  • Prof. Frank Dudbridge
• 30 min
  13. Genome scanning by composite likelihood

  • Dr. Andrew Collins
• 41 min
  14. Multistage sampling for genetic studies

  • Prof. Robert Elston
• 39 min
  15. Screening large-scale association study data: exploiting multi-gene interactions with random forests

  • Dr. Kathryn Lunetta
• 43 min
  16. A survey of multi-locus methods for analysis of large SNP datasets

  • Mr. A. Geert Heidema
• 34 min
  17. Sequential analysis methods in genomic scans

  • Prof. Michael Province

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Learning objectives
3. Definition: genetic association
4. Example 1: HIV-1 anti-body resistance
5. Example 2: number of positive skin tests
6. Example 3: Alzheimer-free survival and APOE
7. Illustration of genetic association
8. Linkage disequilibrium
9. Case-control analysis
10. Case-control analysis: testing for association
11. Samples from mixed populations
12. Population admixture: solutions
13. Case-control analysis: dichotomous trait
14. Family-based association analysis
15. Family-based association studies
16. The transmission disequilibrium test (1)
17. The transmission disequilibrium test (2)
18. The transmission disequilibrium test (3)
19. Summary of TDT
20. An alternative formula for the TDT
21. The variables of the alternative test
22. Computation using Mendelian transmission
23. An alternative formula for the TDT: FBATs
24. Limitations of FBAT/TDT approach
25. FBATs: no parental genotypes (1)
26. FBATs: no parental genotypes (2)
27. The general FBAT
28. The FBATs for quantitative traits
29. First option of phenotype coding
30. Second option of phenotype coding
31. Summary of FBATs

Topics Covered

• Definition: genetic association
• Examples
• Linkage disequilibrium
• Case-control analysis
• Samples from mixed populations
• Population admixture
• Dichotomous trait
• The transmission disequilibrium test (TDT)
• An alternative formula for the TDT: FBATs
• FBATs: no parental genotypes
• The general FBAT
• FBATs for quantitative traits

Links

Series:

• Genetic Epidemiology II

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Dr. Christoph Lange has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.