Registration for a live webinar on 'Innate immunity, inflammation and cancer' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- Introduction to Free Radicals and Oxidative Stress
- Chemistry, Biochemistry and Cell Biology
-
2. Peroxynitrite biochemistry oxidation and nitration reactions
- Prof. Rafael Radi
- Oxidative Damage to Cellular Constituents
- Cellular Protection Against Oxidative Stress
-
4. The SODs
- Prof. Daret St. Clair
-
5. Glutathione: antioxidant defense and regulation of its synthesis
- Prof. Henry Jay Forman
-
6. Vitamin E and the metabolic syndrome
- Prof. Maret Traber
-
7. Cell signaling by vitamin E
- Prof. Angelo Azzi
- Fertility, Growth, Development, Aging and Free Radicals
-
8. Selenium and male fertility
- Prof. Matilde Maiorino
- Free Radicals and Disease
-
9. Oxidative stress and disease: atherosclerosis
- Prof. Giuseppe Poli
- Archived Lectures *These may not cover the latest advances in the field
-
11. The chemistry and biochemistry of partially reduced oxygen species
- Dr. Willem Koppenol
-
12. Chemistry and biochemistry of molecular probes used in the detection of reactive oxygen and nitrogen species
- Prof. Balaraman Kalyanaraman
-
13. Generation of reactive oxygen species by mitochondria
- Dr. Enrique Cadenas
- Dr. Derick Han
-
14. Exercise and free radical generation by contracting skeletal muscle
- Prof. Malcolm Jackson
-
15. Lipid peroxidation: from basic mechanisms to clinical relevance
- Prof. Jason Morrow
-
16. Protein oxidation and removal of oxidized proteins by proteolysis
- Prof. Tilman Grune
-
17. Oxidative stress in aging
- Dr. Jose Vina
-
18. Oxidative stress in disease: cardiac ischemia/reperfusion injury
- Prof. Jay Zweier
-
19. How trypanosomes cope with oxidative stress
- Prof. Leopold Flohe
-
20. Oxidative stress in ALS
- Prof. Dame Pamela Shaw
-
21. Antioxidants and immune response and infectious diseases
- Prof. Simin Meydani
-
22. Oxidative stress in development and neonatal diseases
- Dr. Phyllis Dennery
-
24. Oxidative DNA damage: mechanisms, repair and disease
- Prof. Miral Dizdaroglu
Printable Handouts
Navigable Slide Index
- Introduction
- Why we all get rusty
- The oxygen paradox
- The oxygen paradox explained
- Fire
- Origin of oxygen and why it is dangerous (1)
- Origin of oxygen and why it is dangerous (2)
- Blue-green algae (cyanobacteria) in the oceans
- Plants
- Oxygen is the waste product of photosynthesis
- Carbon-oxygen balance
- Oxygen as the world's first major pollutant
- Aerobic respiration
- Free radicals, oxidants and oxidative stress
- Free radicals in biology
- Major reactive oxygen/nitrogen species
- Sources of free radicals and RO and RN species
- Radiation
- Smog
- Intermediates of NO oxidation
- Food and drinks as a source of free radicals
- Environmental toxins
- Metabolic sources of free radicals
- Electron micrograph of a mitochondrion
- Mitochondrial electron transport chain
- The univalent pathway for oxygen reduction
- Other metabolic sources of free radicals
- Neutrophyl phagocytosis and cytotoxicity
- The NADPH-oxidase system
- Hydrogen peroxide generation by phagocytes
- Hypochlorous acid generation by phagocytes
- Medical and dental sources of free radicals
- Drugs we need to consider
- Anthracycline reaction with NADH-dehydrogenase
- Oxygen-derived radicals and tissue injury
- All reduced carbons are substrates for oxidation
- DNA damage and oxygen radical toxicity
- Types of oxidative damage to DNA
- Membrane lipid peroxidation
- Oxidative damage to proteins
- Chemistry experiments with free radicals
- Is that really all there is?
- Antioxidants and vitamins
- Antioxidant compounds
- Natural alpha-tocopherol
- Antioxidant enzymes
- Enzymatic defense mechanisms
- The dismutation of superoxide
- Mechanisms of antioxidant enzymes
- Cycle of hydrogen peroxide reduction
- Dismutation of superoxide
- Keeping balance between damage and defence
- Antioxidant defense and repair systems
- Damage removal, repair and replacement systems
- DNA repair
- Common mechanisms of DNA damage and repair
- Lipolysis and repair of oxidized lipids
- Phospholipase A2
- Activity of phospholipase A2
- Proteolytic degradation of oxidized proteins
- Proteasome
- Degradation of oxidized proteins by proteasome (1)
- Degradation of oxidized proteins by proteasome (2)
- Protection of mitochondrial proteins
- Lon protease
- Structure of Lon protease
- Oxidative stress - review
- Adaptation to oxidative stress
- Adaptation to hydrogen peroxide in HA-1 cells
- Hydrogen peroxide affects cell growth and viability
- Altered gene expression and oxidative stress (1)
- Altered gene expression and oxidative stress (2)
- Spectrum of oxidative stress responses
- Cellular responses to oxidative stress - review
- The importance of growth-arrest
- Effects of free radicals and oxidative stress
- The free radical theory of aging
- Fountain of youth'' and anti-aging drugs
- Oxidative stress in aging
- Free radicals and disease
Topics Covered
- The oxygen paradox
- Oxygen origin
- Free radicals, oxidants and oxidative stress
- Sources of free radicals
- Environmental toxins
- Metabolic sources of free radicals: mitochondrial electron transport, phagocytes, peroxisomes, autooxidation
- Medical and dental sources of free radicals: x-rays, g-rays, drugs
- DNA damage and oxygen radical toxicity
- Antioxidant compounds and enzymes
- The dismutation of superoxide
- Mechanisms of antioxidant enzymes
- Antioxidant defense and repair systems
- Removal of oxidized DNA bases and DNA repair
- Lipolysis and the repair of oxidized lipids and lipid membranes
- Selective proteolytic degradation of oxidized proteins
- The LON protease
- Adaptation to oxidative stress
- Long-term effects of free radicals and oxidative stress: aging and disease
Talk Citation
Davies, K. (2007, November 1). Introduction to free radicals and the oxygen paradox: oxidative stress in biology, aging & disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 28, 2024, from https://hstalks.com/bs/374/.Export Citation (RIS)
Publication History
Financial Disclosures
- Professor Kelvin Davies has no commercial/financial relationships to disclose
Introduction to free radicals and the oxygen paradox: oxidative stress in biology, aging & disease
Published on November 1, 2007
57 min
A selection of talks on Biochemistry
Hide