• Introduction to Calcium Signaling
• 72 min
  1. Introduction to cellular calcium signaling

  • Dr. Martin Bootman
• 20 min
  2. Monitoring Ca2+ concentration in living cells

  • Dr. Marisa Brini
• 30 min
  3. Cell boundary theorem

  • Prof. Eduardo Ríos
• Calcium Influx
• 19 min
  4. Arachidonic acid and store-independent Ca2+ entry

  • Dr. Luca Munaron
• 34 min
  5. Voltage-dependent calcium channels

  • Prof. Annette Dolphin
• 34 min
  6. Protein networks of voltage-gated Ca2+ channels – proteomic & functional analysis of local Ca2+ signalling

  • Prof. Bernd Fakler
• 37 min
  7. Intracellular Ca2+ signaling: calcium influx

  • Prof. Anant Parekh
• 60 min
  8. Molecular identification of the CRAC channel

  • Prof. Michael Cahalan
• 35 min
  9. TRP channels with diverse permeability profiles: regulation of blood pressure and fertility

  • Prof. Marc Freichel
• Calcium Release
• 53 min
  10. The InsP3 receptor calcium release channel

  • Prof. J. Kevin Foskett
• 31 min
  11. Molecular biology of ryanodine receptors: an overview

  • Dr. Christopher George
  • Prof. F. Anthony Lai
• 57 min
  12. cADPR and NAADP: messengers for calcium signalling

  • Prof. Antony Galione
• 43 min
  13. Ryanodine receptors and cardiac function

  • Prof. David Eisner
• Calcium Efflux and Sequestration
• 45 min
  14. Sodium-calcium exchange

  • Prof. John Reeves
• Organelle Calcium
• 42 min
  15. Regulation and role of mitochondrial Ca2+ homeostasis

  • Prof. Rosario Rizzuto
• 54 min
  16. Peroxisomes and Golgi apparatus as players in Ca2+ homeostasis

  • Dr. Paola Pizzo
  • Dr. Alex Costa
• 34 min
  17. Ca2+ dynamics between mitochondria and the endoplasmic reticulum

  • Dr. Wolfgang Graier
• 26 min
  18. Nuclear calcium signaling

  • Dr. Oleg Gerasimenko
  • Dr. Julia Gerasimenko
• Spatiotemporal Calcium Signals
• 54 min
  19. Regulation of intracellular calcium signaling, localized signals and oscillations

  • Prof. Barbara Ehrlich
• 43 min
  20. Modeling Ca2+ signals: understanding Ca2+ regulatory networks in cells: introduction and basic concepts

  • Dr. David Friel
• 41 min
  21. Modeling Ca2+ signals: understanding Ca2+ regulatory networks in cells - Ca2+ stores: endoplasmic reticulum, calcium oscillations

  • Dr. David Friel
• 49 min
  22. Modeling Ca2+ signals: understanding Ca2+ regulatory networks in cells - Ca2+ stores: mitochondria, models of spatially non-uniform Ca2+ signals, applications to analysis of experimental results

  • Dr. David Friel
• Calcium Effectors
• 34 min
  23. Neuronal calcium sensor proteins: calcium sensors and regulators of diverse cellular functions

  • Prof. Bob Burgoyne
• 41 min
  24. Calcium-regulated adenylyl cyclases and cyclic AMP compartmentalization

  • Prof. Dermot Cooper
• 32 min
  25. Calcium and transcription-coupling

  • Dr. Karen Lounsbury
• 50 min
  26. Cellular calcium (Ca2+) buffers

  • Prof. Dr. Beat Schwaller
• 24 min
  27. Extracellular calcium signaling

  • Dr. Aldebaran M. Hofer
• 50 min
  28. Ca2+, fertilization and egg activation

  • Prof. Karl Swann
• 24 min
  29. Calcium regulation of transcription in plants

  • Prof. Hillel Fromm
• 34 min
  30. Mechanisms regulating STIM expression and function in Ca2+ signaling

  • Dr. Jonathan Soboloff
• 46 min
  31. Dynamic signal encoding in the S. cerevisiae calcium response

  • Dr. Chiraj Dalal
• Calcium and Disease
• 43 min
  32. Polycystins, calcium signaling and pathogenesis of polycystic kidney disease

  • Prof. Laura del Senno
• 28 min
  33. Ca2+ alterations in familial Alzheimer's disease (FAD)

  • Dr. Paola Pizzo
• 38 min
  34. Pancreatitis and calcium signaling

  • Prof. Ole Petersen
• 47 min
  35. Mechanism-based therapies for heart failure and cardiac arrhythmias

  • Prof. Andrew Marks
• 46 min
  36. Genetic defects and calcium

  • Prof. Tullio Pozzan
• Archived Lectures *These may not cover the latest advances in the field
• 31 min
  37. Calcium, calmodulin and calcineurin

  • Prof. Stephen Bolsover
• 34 min
  38. Calcium flickers steer cell migration

  • Prof. Heping Cheng
• 28 min
  39. Automated Ca2+ imaging of chemosensory neurones in C.elegans

  • Dr. Nikos Chronis
• 46 min
  40. Ca2+ and the regulation of small GTPases

  • Prof. Peter Cullen
• 35 min
  41. Genetically encoded Ca2+ indicators: molecular scale measurements in mammals in vivo

  • Dr. Michael I. Kotlikoff
• 35 min
  42. Capacitative (store-operated) calcium entry

  • Dr. Jim Putney
• 47 min
  43. The molecular biology of the inositol trisphosphate receptor

  • Dr. Randen Patterson
• 50 min
  44. Coordinated Ca2+ release from intracellular Ca2+ stores

  • Prof. Ole Petersen
• 45 min
  45. The plasma membrane calcium pump: biochemistry, physiology and molecular pathology

  • Prof. Ernesto Carafoli
• 60 min
  46. The calcium saga: a matter of life and death

  • Prof. Pierluigi Nicotera
• 22 min
  47. Ca2+ efflux and Ca2+ signals

  • Dr. Anne Green
• 31 min
  48. Organellar calcium pumps of the golgi and ER: from yeast to human

  • Prof. Rajini Rao
• 58 min
  49. Spatial and temporal aspects of cellular calcium signals: 'elementary' signals and waves

  • Prof. Ian Parker
• 26 min
  50. Modeling Ca2+ signals

  • Dr. David Friel

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Calcium signals and waves
3. Signal transduction via Ca2+
4. Cells utilise different sources of Ca2+ for signaling
5. Ca2+ release pathways
6. Ca2+ signalling via NAADP and cADPR
7. Store-operated Ca2+ entry
8. Calcium 'on' and 'off' mechanisms
9. Ca2+ acts in different time domains
10. Ca2+ signals can have different frequencies
11. Ca2+ signals can have varying amplitudes
12. Different spatial dimensions of Ca2+ signals
13. Ca2+-induced gene transcription
14. Neuronal development encoded by Ca2+ signals
15. Different cells express varying 'toolkit' components
16. Ca2+ signalsomes undergo self-assessment
17. Cells express multiple Ca2+ release pathways
18. The phosphoinositide signal transduction pathway
19. Inositol 1, 4, 5-trisphosphate receptors
20. InsP3 receptors are located on the ER
21. Mitochondrial calcium uptake monitoring
22. The mitochondrial Ca2+ uptake pathway
23. Mitochondrial calcium uptake and the Krebs cycle
24. Mitochondrial calcium uptake leads to apoptosis
25. InsP3 receptors accelerate apoptosis
26. InsP3 receptors bind multiple accessory proteins
27. Bcl-2 "B cell lymphoma-2"
28. Bcl-2 reduces InsP3 receptor activity
29. Bcl-2 suppresses InsP3-induced Ca2+ release
30. Calcium and apoptosis
31. Cells express multiple Ca2+ release pathways
32. Excitation-contraction coupling in cardiac muscle
33. Ca2+ underlies excitation-contraction coupling (1)
34. Inhomogeneous Ca2+ signals in atrial muscle (1)
35. Inhomogeneous Ca2+ signals in atrial muscle (2)
36. Ca2+ underlies excitation-contraction coupling (2)
37. Atrial myocyte Ca2+ channel distribution
38. Atrial myocyte excitation-contraction coupling (1)
39. Ca2+ underlies excitation-contraction coupling (3)
40. Physiological sympathetic inotropy stimulation
41. Isoproterenol increases cellular contraction
42. Endothelin-1 increases atrial cell contractility
43. Endothelin-1 causes positive inotropy
44. Positive inotropy and increased contraction in atria
45. Atrial myocyte excitation-contraction coupling (2)
46. Endothelin-1 causes inotropy and arrhythmias
47. Endothelin-1 evokes spontaneous Ca2+ transients
48. Dysrhythmias and spontaneous Ca2+ release
49. Atrial myocyte at rest
50. Atrial myocyte showing spontaneous Ca2+ sparks
51. Spontaneous calcium signals cause depolarisation
52. Further reading

Topics Covered

• Introduction to the spatial and temporal complexity of cellular calcium signals
• Calcium 'on' and 'off' mechanisms
• The calcium signaling toolkit
• Calcium sources
• Calcium waves
• Calcium oscillations
• Cell-specific calcium signaling proteomes
• Examples of calcium signaling differentially controlling cellular processes such as gene transcription and neuronal differentiation
• Inositol 1,4,5-trisphosphate receptors as an example of a calcium release system
• Mitochondrial calcium uptake
• Regulation of apoptosis by calcium
• Cardiac calcium signaling
• Atrial myocytes regulate contraction by modulating the spatial properties of their calcium signals
• Calcium-induced arrhythmias

Links

Series:

• Calcium Signaling I

Categories:

• Biochemistry
• Cell Biology

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on October 1, 2007
• Updated on July 15, 2012

Financial Disclosures

• Dr. Martin Bootman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.