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1. Introduction
2. Potential advantages of mAb
3. Challenges for mAb
4. Antibody based therapeutic proteins
5. Immunoligand
6. Attributes of immunoligands
7. Immunoligands can be readily designed
8. Creation of Ig-based fusion proteins
9. Creation of cytolytic human IL-2/Fc fusion protein
10. Creation of non-cytolytic IL-2/Fc fusion protein
11. CTLL-2 proliferation assay
12. Altering biological functions of Fc region (1)
13. Altering biological functions of Fc region (2)
14. IL-2/Fc circulating half-life
15. Non-cytolytic IL-2/Fc fusion protein
16. Vaccine trial design
17. Vaccine trial results
18. Cytolytic IL-2/Fc blocks autoimmunity
19. Creating cytolytic IL-15R antagonist fusion protein
20. IL receptors subunits
21. Role of glutamines found in T cells growth factors
22. Creating cytolytic IL-15 mutant/Fc fusion protein
23. Mutant IL-15/Fc inhibits IL-15 mediated cell growth
24. Creating transplant tolerance
25. Application of immunoligand
26. Challenges for immunoligands

Topics Covered

• Potential advantages of mAB
• Challenges for mAB
• Antibody based therapeutic proteins
• Attributes of immunoligands
• Creation of Ig-based fusion proteins
• Non-cytolytic IL-2/Fc fusion protein
• Vaccine trial design
• Creation of cytolytic IL-15R antagonist fusion protein
• Application of immunoligand: immunogen for mAB production, to stain the cognate ligand, to identify cell surface cognate ligands via immunoprecipitation, to create long lived proteins to test the function of the targeting ligand in vivo and to modulate immune responses
• Challenges for immunoligands

Links

Series:

• Monoclonal Antibodies as Therapeutic Agents

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on June 13, 2019

Financial Disclosures

• Prof. Terry Strom has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.