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1. Introduction
2. Introduction of Retorovirus
3. Disease derived from Retorovirus
4. Discovery of ATL disease entity
5. HTLV-1 discovery and world-wide distribution
6. Gallo meeting, Kyoto (12.01.03)
7. Cloning of IL-2 receptor alpha chain
8. Discovery of ATL-derived factor (ADF)
9. ADF is the human thioredoxin (TRX)
10. Regulation of thioredoxin gene expression
11. TRX transgenic and knock-out mice
12. Survival and influenza resistance of TRX TG mice
13. The thioredoxin system
14. Thioredoxin superfamily
15. IgE binding factor, GIF/MIF and TRX
16. ADF peptide sequence A and B
17. Dualistic function of MIF/GIF
18. Inhibition of MIF expression by exogenous rhTRX
19. Reciprocal regulation of TRX and GIF/MIF
20. TRX1/ADF as an endogenous inhibitor of MIF/GIF
21. Modulation of inflammation and cell death by TRX
22. Modified TRX1 rapidly enters into cells (1)
23. Modified TRX1 rapidly enters into cells (2)
24. Raft fractionation of TRX-C35S-expressing cells
25. rTRX-C35S interanalization is competed by wtTRX
26. Lipid raft-mediated TRX transfer into cells
27. rTRX suppresses bleomycin-induced lung injury
28. Therapeutic effect of rTRX against lung disease
29. Resistance against allergic inflammation/COPD
30. Attenuation of Indomethacin-induced gastric ulcer
31. Influenza virus infection resistance
32. Possible aplication of rTRX in respiratory infections
33. Thioredoxin binding proteins
34. TBP-2 - a TRX binding protein
35. TBP-2: tumor suppressor for HTLV-I leukemia
36. TBP-2 knock-out and transgenic mice
37. Thiol-dependent redox regulatory network update
38. Clinical trials involving rTRX
39. Redox research, International Redox Network

Topics Covered

• Life cycle of retroviruses
• Diseases derived from retroviruses
• Adult T-cell leukemia and HTLV-1 retrovirus
• ADF/TRX upregulation in HTLV-I T-cell and EBV B-cell transformation
• Regulation of thioredoxin gene expression
• TRX TG and KO mice
• The thioredoxin system
• MIF/GIF
• Inflammatory response
• TBP2: tumor suppressor for HTLV-I leukemia
• Clinical trials for inflammatory diseases

Links

Series:

• Retroviruses

Categories:

• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Junji Yodoi has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.