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1. Introduction
2. Calmodulin sequences
3. Calmodulin structure - EF hands
4. EF hand proteins
5. Each calmodulin molecule binds four calcium ions
6. Calmodulin changes upon calcium binding
7. Cartoon of calmodulin binding calcium
8. Processes regulated by calmodulin
9. Classical activation of a target by Ca:calmodulin
10. Calmoduliun targets - 1-10 family
11. Calmoduliun targets - IP3
12. Calmoduliun targets - 1-14 family
13. Calmodulin activated Ca channel
14. Calmoduliun targets - 1-16 family
15. Full list of calmodulin targets
16. Lecture part 1: calmodulin and EF hand proteins
17. Calmodulin-dependent protein kinases
18. CaM kinase II
19. CaM kinase II is a multimeric enzyme
20. 2nd example of CaMKII activation
21. CaMKII shows 'molecular memory'
22. CaMKII and learning
23. Part 2: calmodulin dependent protein kinases
24. Calcineurin
25. Calcineurin - structure and function
26. Cyclosporin
27. Calcineurin involved in NFAT signaling pathway
28. Calcineurin specificity
29. PP1
30. Slingshot
31. Calcineurin activates downstream phosphatases
32. CaMKII vs. calcineurin - mild increase in Ca
33. CaMKII vs. calcineurin - intense increase in Ca
34. CaMKII vs. calcineurin - summary
35. Spatial and temporal affects combined
36. Lecture part 3: calcineurin
37. Summary of the lecture
38. Acknowledgements
39. References (1)
40. References (2)

Topics Covered

• Calmodulin is highly conserved
• Calmodulin structure
• EF hand proteins
• Calcium binding
• Calmodulin targets
• Mechanism of calmodulin action
• Calmodulin-dependent protein kinases
• Calmodulin dependent protein kinase II autonomy
• Calcineurin structure and activation
• Action of cyclosporin
• NFAT signaling
• Phosphatases downstream of calcineurin
• Differential responses of calmodulin-dependent protein kinase II and calcineurin to calcium signals

Links

Series:

• Calcium Signaling I

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on June 22, 2016

Financial Disclosures

• Prof. Stephen Bolsover has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.