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1. Introduction
2. The Asian continent
3. Human expansion "out of Africa"
4. Two postulated routes out of Africa
5. Pakistan and its neighbors
6. Ethnic groups from Northern Pakistan
7. Ethnic groups from Southern Pakistan
8. DNA structure
9. Karyogram of a human male
10. Organization of the human genome
11. Genetic markers for population analyses
12. Polymerase chain reaction (PCR)
13. DNA amplification by PCR
14. Alu polymorphisms
15. Microsatellites or short tandem repeats (STRs)
16. Single nucleotide polymorphisms
17. DHPLC
18. SNP detection using DHPLC
19. DNA sequencing
20. DNA sequencing showing SNP
21. Biallelic markers identify stable lineages
22. Microsatellites and biallelic markers traits
23. Ancestry proportion based on Alu polymorphism
24. Continental phylogenetics
25. PCA of grouped world populations
26. Structure analysis of world populations
27. Structure analysis of Asian populations
28. Autosomal microsatellites
29. The Y chromosome is inherited paternally
30. Mitochondrial DNA markers used for analysis
31. Asian Y-lineages
32. Worldwide distribution of Y lineages
33. Y lineages in West Asia
34. PCA of populations from the Middle East
35. Y-lineage O3 (M122) is common in China
36. Distribution of Y lineages in Japan
37. Comparison of Indian and Eurasian populations
38. Spread of Y lineages in Asia
39. R1a1 lineage in the Indo-Pak sub-continent
40. R2 lineage in the Indo-Pak sub-continent
41. Distribution of L1 lineage in India and Pakistan
42. Median joining network of L lineages in Pakistan
43. Indo-Pak mitochondrial lineages
44. Mitochondrial lineages
45. mtDNA variation in West Asia and Pakistan
46. HLA genotyping by PCR
47. Phylogenetic tree of HLA
48. Correspondence analysis based on HLA
49. Genetic signature of Alexander's invasion?
50. Genetic signature of Mongol invaders
51. Pakistani population origins: Hazara
52. Pakistani population origins: Kalash
53. Pakistani population origins: Parsi
54. Pakistani population origins: Negroid Makrani
55. Pakistani population origins: Hunza Burusho
56. Summary
57. Conclusions (1)
58. Conclusions (2)
59. Thank you

Topics Covered

• Population genetics
• Pakistan and south west Asia
• Human migrations
• DNA markers
• Alu repeats, SNPs and STRs
• Y chromosome, mitochondrial DNA and HLA markers unravel genetic relationships among populations in Asia and Pakistan

Links

Series:

• Human Population Genetics I

Categories:

• Genetics & Epigenetics

Talk Citation

Mehdi, S.Q. (2007, October 1). Genetics of Pakistani populations in an Asian and global context [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/325/.
Export Citation (RIS)

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. S. Qasim Mehdi has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.