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1. Introduction
2. Overview: apoptosis pathways in cancer therapy
3. The apoptosis pathways
4. The intrinsic and extrinsic pathways
5. Extrinsic pathway: Fas
6. Bcl-2 in the intrinsic pathway (1)
7. Bcl-2 in the intrinsic pathway (2)
8. Pro/anti-apoptotic members of the Bcl-2 family
9. The final pathway: caspases
10. Regulation of the Apoptotic pathways
11. Pathways that regulate apoptosis (1)
12. p53
13. Ubiquitin/proteosome pathway
14. Aggresome
15. NF-kappa B characteristics (1)
16. NF-kappa B characteristics (2)
17. PI3K/Akt pathway
18. PI3K/Akt
19. mTOR
20. PKC
21. Heat shock proteins (1)
22. Heat shock proteins (2)
23. Regulators of the apoptosis pathways
24. Pathways that regulate apoptosis (2)
25. Agents that target the extrinsic pathway
26. Agents that target the intrinsic pathway
27. Agents that target the mitochondrial membrane
28. Agents that target Bcl-2 (1)
29. Agents that target Bcl-2 (2)
30. Agents that target the common pathway
31. Inhibitors of apoptosis modulators (1)
32. Inhibitors of apoptosis modulators (2)
33. Inhibitors of p53
34. Proteosome inhibitors (1)
35. Proteosome inhibitors (2)
36. Aggresome inhibitors
37. Inhibitors of the PI3K pathway
38. PKC inhibitor
39. Heat shock proteins
40. NF-kappa B inhibitors
41. Summary

Topics Covered

• Apoptosis pathways
• Pathways regulating the intrinsic and extrinsic pathways
• ovel therapeutic agents in cancer therapy that target the apoptosis pathways and the modulators of apoptosis

Links

Series:

• Apoptosis

Categories:

• Cancer
• Cell Biology

Therapeutic Areas:

• Immunology & Inflammation
• Oncology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on January 15, 2020

Financial Disclosures

• Dr. Irene Ghobrial has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.