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0:00
Hello,
my name is Lynda Bonewald.
And I'm from the University
of Missouri at Kansas City.
And the title of my
talk is The Osteocyte.
0:12
First, I would like to give you
an outline of the presentation.
I'll talk about
osteocytes in history,
their first proposed function,
that of osteocytic osteolysis,
their second proposed function,
that of mechanosensation,
then about how osteocytes can
serve as secretory cells regulating
skeletal remodeling
through molecules,
such as sclerostin and RANKL, fifth,
how osteocytes are endocrine cells
that can target kidney and muscle.
And finally, I will summarize
the functions of osteocytes.
0:50
Now, there are three
types of bone cells.
There are the osteoclasts
that resorb bone
and the osteoblasts that make bone.
And then there is the third the
cell type called the osteocyte.
1:05
Osteoclasts and osteoblasts
are defined by their function.
Osteoclasts resorb bone
and osteoblasts make bound.
However, osteocytes are
defined by their location.
So this implies a lack of
knowledge regarding their function.
1:23
This slide shows osteocyte ontogeny.
The osteocyte is descended
from the pre-osteoblast, which
differentiates into the
matrix-producing osteoblast.
And by some unknown mechanism, some
of these cells become osteocytes.
And then once they're surrounded by
osteoid, they begin to mineralize.
And once surrounded by mineral,
they are called mature osteocytes.
