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1. Introduction
2. Objectives
3. Colorectal cancer precursors
4. Classification of colorectal polyps
5. Proposed serrated pathway of MSI-H CRC
6. Recognition of high risk precursor lesions
7. Detection of polyps (1)
8. Detection of polyps (2)
9. Detection of high risk patients
10. Hereditary colon cancer syndromes
11. Hereditary polyposis syndromes
12. Autosomal dominant inheritance
13. Autosomal recessive inheritance
14. Division of hereditary polyposis syndromes
15. Adenomatous polyposis syndromes
16. Human chromosomes
17. Signs of adenomatous polyposis syndromes
18. Presentations of polyposis syndromes
19. Adenoma in adenomatous polyposis syndromes
20. Familial adenomatous polyposis
21. Genetics of FAP
22. Phenotypic variations of FAP
23. FAP phenotype is genotype dependant
24. FAP colon phenotype is genotype dependant
25. Extra-intestinal features of FAP
26. Gastric features of FAP
27. Duodenal features of FAP
28. Staging of duodenal polyposis
29. Duodenal cancer risk based upon stage
30. UGI surveillance in adenomatous polyposis
31. Prophylactic duodenal surgery
32. MYH associated polyposis
33. MYH associated polyposis study (1)
34. MYH associated polyposis study (2)
35. CRC risk associated with MYH (1)
36. Penetrance curve of biallelic MUTYH mutation
37. CRC risk associated with MYH (2)
38. Polyposis phenotype in MYH CRC
39. MAP phenotype
40. Colorectal surveillance of polyposis
41. Surgical guidelines
42. Chemoprevention of FAP
43. Pediatric chemoprevention of FAP
44. Genetic testing in APC (1)
45. Genetic testing in APC (2)
46. Results of APC genetic testing
47. MYH genetic testing
48. Peutz-Jeghers syndrome
49. Hallmarks of PJS
50. Diagnostic criteria for PJS
51. Frequency of polyps in PJS
52. Cancer risk in PJS
53. Risk of non-GI cancer in PJS
54. Risk of GI cancer in PJS
55. Endoscopic evaluation in PJS
56. Endoscopic surveillance of PJS
57. Indication for genetic testing in PJS
58. Genetic test results in PJS
59. Juvenile polyposis syndrome
60. Genetics of JPS
61. Cancer risk in JPS
62. Clinical features JPS
63. Diagnostic criteria of JPS
64. GI screening in JPS
65. Management of JPS
66. Indication for genetic testing in JPS
67. Genetic test results in JPS
68. Cowden's syndrome (1)
69. Cowden's syndrome (2)
70. Clinical manifestations of CS
71. Diagnostic criteria for CS
72. GI polyps in CS
73. Frequency of CS features
74. Management of CS
75. Summary

Topics Covered

• Colorectal cancer is a molecularly heterogeneous disease known to arise from two distinct origins, the adenomatous and serrated pathways
• Sessile serrated polyps, also known as sessile serrated adenomas, and traditional serrated adenomas are believed to be the precursor lesions for serrated carcinomas which account for up to 30% of sporadic colorectal cancers
• When colorectal polyps or cancer occur in multiple generations, numerous relatives, at a young age of onset or in association with unusual numbers of lesions or extra-colonic tumors, a hereditary colorectal cancer syndrome should be suspected as a potential cause
• The ability to recognize a patient with a hereditary colorectal cancer syndrome allows a practitioner to stratify her or his patient's lifetime cancer risk and devise prevention and management strategies for risk reduction in the patient and family once the diagnosis is confirmed

Links

Series:

• Gastroenterology and Hepatology

Categories:

• Cancer
• Clinical Practice

Therapeutic Areas:

• Gastroenterology & Nephrology
• Oncology

Talk Citation

Burke, C.A. (2011, January 5). Colorectal cancer and hereditary colon cancer syndromes [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 20, 2024, from https://hstalks.com/bs/1909/.
Export Citation (RIS)

Publication History

• Published on January 5, 2011

Financial Disclosures

• Prof. Carol A. Burke has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.