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1. Introduction
2. Electrophoresis: a powerful technique in genetics
3. Electrophoretic mobility
4. Mobility of two different amino-acids
5. Harry Harris (1919-1994)
6. Specific detection methods
7. Mutation in phosphoglucomutase 1 (PGM1)
8. Detecting size differences by electrophoresis
9. Subtle changes - isoelectric focussing
10. Protein polymorphism
11. DNA polymorphism and electrophoresis
12. Detection of size and conformational differences
13. Detection of different number of tandem repeats
14. Genotype and phenotype
15. Crosses in the ABO blood group system
16. Difficulties in interpreting the correct genotype
17. Epistasis
18. Multiple molecular forms or isozymes/forms
19. Many proteins are encoded by multiple genes
20. Subunits of phosphorylase kinase
21. Multimeric proteins
22. Subunits of lactate dehydrogenase
23. Electrophoresis of samples from three people
24. Distinguishing multiple genes from multiple alleles
25. Analysis of enzyme polymorphism and isozyme
26. Human genome sequence HapMap
27. Functional implications of genetic variation

Topics Covered

• Electrophoresis
• Electrophoretic mobility
• Amino acids
• Specific detection methods
• Detecting protein size differences
• Ioselectric focusing
• Protein polymorphism
• DNA polymorphism and electrophoresis
• Tandem repeats
• Genotype and phenotype
• Epistasis
• Isozymes
• Many proteins are encoded by multiple genes
• Multimeric proteins
• How do we know that a protein is encoded by multiple genes/alleles?
• HapMap
• Functional implications of genetic variation

Links

Series:

• Introduction to Human Genetics

Categories:

• Genetics & Epigenetics

Talk Citation

Publication History

• Published on December 28, 2009

Financial Disclosures

• Prof. Dallas Swallow has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.