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Printable Handouts
Navigable Slide Index
- Introduction
- Important streptococcal species
- S. agalactiae - neonatal sepsis and meningitis
- S. pneumoniae
- S. pneumoniae - a candy coated bacterium
- S. pyogenes - the chain that links throat to heart
- S. pyogenes infections
- Serious life threatening complications
- Rheumatic fever - link to the heart
- APSGN (1)
- APSGN (2)
- Invasive S. pyogenes disease
- Child-bed sepsis (puerperal sepsis)
- Others conditions associated with S. pyogenes
- Psoriasis and obsessive compulsive behavior
- Microbiology of S. pyogenes
- Identification of group A Streptococcus
- S. pyogenes is resistant to innate immunity
- S. pyogenes interaction with host cell
- S. pyogenes surface is determinant of virulence
- Masters of immune avoidance
- Molecular mimicry - hyaluronic acid
- Binding of HA to CD44
- Key complement components
- Destruction of host chemotactic signals
- C5a peptidase (1)
- C5a peptidase (2)
- The M protein (1)
- The M protein (2)
- Tonsils are reservoir for recurrent infection
- S. pyogenes enter tonsils through M cells
- Streptococcal adhesins and invasins
- Multiple pathways of invasion
- M1-Fn and Sfb1-Fn invasion signals
- S. pyogenes infection and TGF-beta (1)
- S. pyogenes infection and TGF-beta (2)
- Superantigens
- Superantigens are nonspecific activators of T cells
- Summary
Topics Covered
- Important Streptococcal species
- S. pyogenes: the chain that links the throat to the heart
- Life threatening complications
- Rheumatic fever
- Acute post streptococcal glomerulonephritis
- Invasive S. pyogenes disease
- Strep throat activates psoriasis and obsessive compulsive behavior
- Identification of group A streptococcus
- S. pyogenes expresses a complex array of factors that interact with host defenses
- Molecular mimicry hides bacterium from host's defenses
- Key complement components
- Destruction of host chemotactic signals is critical for initiation of infection
- C5a peptidase
- M protein
- Tonsils are reservoir for recurrent infection
- Superantigens
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Talk Citation
Cleary, P.P. (2009, October 29). Streptococcus pyogenes disease and molecular pathogenesis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 25, 2024, from https://hstalks.com/bs/1480/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. P. Patrick Cleary, Lecturer, shared royalty payments from sales of lecture series.