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1. Introduction
2. E. coli can be commensal
3. E. coli can cause infections
4. How can E. coli cause so many diseases?
5. How do E. coli strains differ from one another?
6. ExPEC
7. UPEC pathogenesis
8. UPEC virulence factors
9. ExPEC gene discovery techniques
10. Sugar coating
11. K2 capsule and serum resistance
12. ETEC disease
13. ETEC pathogenesis
14. Chromosomal factors in ETEC pathogenesis
15. EPEC disease
16. EPEC pathogenesis
17. The bundle-forming pilus
18. The bfp gene cluster
19. A model of the BFP biogenesis machine
20. Diversifying selection of bundlin
21. Specificity of human Ab response against bundlin
22. Attaching and effacing
23. The locus of enterocyte effacement
24. Intimin
25. The translocon of type III secretion system
26. EspB damages the brush border in vivo
27. The translocated Intimin receptor
28. EPEC summary
29. EHEC
30. EHEC clinical features
31. Hemolytic-uremic syndrome (HUS)
32. The relationship between EPEC and STEC
33. The role of eae in attachment in vivo
34. Shiga toxins
35. Shiga toxin production
36. Do antibiotics increase HUS risk?
37. EHEC diagnosis
38. EHEC therapy
39. EHEC prevention
40. EAEC
41. EAEC pathogenesis
42. EIEC and Shigella
43. DAEC
44. Summary
45. Relationships among pathogenic E. coli
46. Acknowledgements

Topics Covered

• How can E. coli cause so many diseases?
• Different E. coli strains
• ExPEC
• UPEC pathogenesis and virulence factors
• ExPEC gene discovery
• ETEC and EPEC disease
• The bundle forming pilus
• BFP biogenesis
• Bundlin
• The locus of enterocyte effacement
• Intimin
• The translocon
• EHEC clinical features
• Shiga toxins
• Do antibiotics increase HUS risk?
• EHEC diagnosis, therapy and prevention
• EAEC pathogenesis
• Relationships among pathogenic E. coli

Links

Series:

• Molecular Basis of Bacterial Infection

Categories:

• Clinical Practice
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Publication History

• Published on November 2, 2009

Financial Disclosures

• Prof. Michael Donnenberg has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.