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1. Introduction
2. The paradox that forged the immune system
3. Commensals vs.pathogens
4. The Yin and Yang of innate immunity
5. Histopatholoy of shigellosis
6. Shigella virulence plasmid - pathogenicity island
7. TTSS of Shigella
8. Shigella invasion of the epithelium
9. Pyroptosis during Shigella invasion
10. Pyroptosis = pro-inflammatory apoptosis
11. Initiation of inflammation during Shigella invasion
12. Innate immune system receptor families
13. Functions of Nod1
14. Proinflammatory process - Nod and TLR
15. NLR: intracellular watchdogs
16. Keeping the intestinal epithelial barrier intact
17. Shigella pathogenicity island - important genes
18. OspG function
19. OspF regulates expression of NF-kB genes
20. OspF function effect on MAPK genes
21. Gene expression in OspF mutants
22. OspF function in suppression of inflammation
23. OspF regulates the translocation of PMN cells
24. IpaH - a new family of E3 ligases
25. Mxie dependant effectors
26. Antimicrobial peptides (AMP)
27. Mxie-dependant effectors and AMP expression (1)
28. Mxie-dependant effectors and AMP expression (2)
29. Mxie-dependant effectors and AMP expression (3)
30. Shigella suppress AMP in the epithelium
31. Suppression of AMP with bacteria progression
32. Downregulation of CCL20
33. Shigella effect on DC recruitment to lamina propria
34. Shigella downregulate defense mechanisms
35. Three responses to microbes - summary
36. Acknowledgements

Topics Covered

• Microbial immunology: understanding how Shigella, through its capacity to invade the gut epithelium, causes its inflammatory destruction
• Identification of the bacterial effectors that regulate the mucosal inflammatory response thus facilitating bacterial colonisation and invasion of the gut

Links

Series:

• Innate Immunity

Categories:

• Immunology
• Microbiology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Sansonetti, P. (2009, June 30). Manipulation of innate immune response: lessons from shigella [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 24, 2024, from https://hstalks.com/bs/1308/.
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Publication History

• Published on June 30, 2009
• Archived on February 25, 2021

Financial Disclosures

• Prof. Philippe Sansonetti has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.