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1. Introduction
2. Overview
3. Visceral pain disorders
4. Epidemiology of IBS
5. Overlap of IBS with other pain syndromes
6. Shared features of functional pain syndromes
7. CNS abnormality in functional pain disorders
8. Alterations in brain responses in pain syndromes
9. Clinical syndrome into biological endophenotypes
10. Genes and biological intermediate phenotypes
11. Visceral stimulus - perception, emotion, cognition
12. Central neurobiological phenomics strategy
13. Temporal dimensions of central pain amplification
14. Altered sensorimotor gating
15. Preattentive sensory gating mechanisms
16. Failure of P50 habituation in IBS patients
17. Role of altered emotional arousal
18. Symptom-related anxiety and pain experience
19. Differences between fear and anxiety effect
20. Altered emotional arousal
21. Threat potentiated startle
22. Threat potentiated startle and pain perception
23. Threat potentiated startle in different syndromes
24. Altered emotional arousal - fMRI
25. Emotional arousal circuit
26. Aversive rectal distension
27. Viewing negative emotional faces
28. Lowering brain serotonin levels alters connectivity
29. Cortico limbic pontine pain modulation circuits
30. Repeated sigmoid stimulation
31. Cortico-limbic-pontine network (1)
32. Cortico-limbic-pontine network (2)
33. Central role of the Insula
34. Role of insula in integration of inputs
35. Brain responses to expected stimulus - design
36. Brain responses to expected stimulus - results
37. Interoceptive and predicted state
38. Acknowledgements

Topics Covered

• Visceral pain disorders
• Epidemiology of IBS
• Overlap of IBS with other functional pain syndromes
• Is there a shared CNS abnormality in functional pain disorders?
• Reported alterations in brain responses in stress-sensitive pain syndromes
• Deconstructing the clinical syndrome into biological endophenotypes
• Identifying associations between genes and biological intermediate phenotypes
• Central neurobiological phenomics strategy
• Temporal dimensions of central pain amplification
• Central pain amplification: altered sensorimotor gating
• Preattentive sensory gating mechanisms
• Role of altered emotional arousal
• Central pain amplification

Links

Series:

• Pain and the Control of Pain

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on January 26, 2009
• Archived on February 25, 2021

Financial Disclosures

• Prof. Emeran Mayer has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.