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1. Introduction
2. BBB is an impediment in CNS drug development
3. CNS drug development
4. The evolving concept of the blood-brain barrier
5. Neurovascular unit as an integrated concept
6. Tight junctions form the 'physical' barrier
7. The transport systems of the blood-brain barrier
8. Strategies to deliver drugs into the brain (1)
9. Strategies to deliver drugs into the brain (2)
10. Strategies to deliver drugs into the brain (3)
11. Routes for drug delivery across the BBB
12. Transcellular lipophilic diffusion
13. Inhibition of efflux pumps
14. Paracellular hydrophilic diffusion
15. Carrier-mediated transport
16. Adsorptive endocytosis
17. Receptor-mediated transcytosis
18. The molecular 'Trojan horses' concept
19. 'Trojan horses'
20. HIR as a 'Trojan horse' for drug delivery to the brain
21. 'Trojan horses' and nanocarriers
22. Considerations in designing 'Trojan horses'
23. Discovery and development of novel 'Trojan horses'
24. Single domain antibodies
25. Single-domain antibody phage display libraries
26. Selection of the BBB - targeting sdAbs
27. Brain-targeting single-domain antibodies
28. Mechanisms of transport
29. Linking molecules to FC5
30. In vivo biodistribution of FC5
31. Improving FC5 pharmacokinetics
32. Brain accumulation of FC5 formulations
33. Detection of FC5 in brain tissues
34. Detection of FC5 by confocal microscopy (1)
35. Detection of FC5 by confocal microscopy (2)
36. Summary
37. FC5-functionalized liposomes
38. Delivery using FC5-functionalized liposomes (1)
39. Delivery using FC5-functionalized liposomes (2)
40. Tailoring BBB delivery strategies (1)
41. Tailoring BBB delivery strategies (2)

Topics Covered

• Restrictive nature of the blood-brain barrier
• Non-vascular routes for brain drug delivery
• Vascular routes for brain drug delivery
• Concept of Trojan horses
• Discovery of novel receptor-mediated transcytosis routes across the blood-brain barrier
• Principles of blood-brain barrier vector development in experimental models

Links

Series:

• The Blood-Brain Barrier

Categories:

• Neuroscience
• Pharmaceutical Sciences

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on March 1, 2008

Financial Disclosures

• Dr. Danica Stanimirovic has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.