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- Introduction and General Properties of Plasmids
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1. Introduction to plasmid biology
- Prof. Emeritus Don Clewell
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2. General properties and applications of plasmids
- Prof. Emeritus Don Clewell
- Replication
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3. Plasmids: copy number control by antisense RNAs
- Prof. Gerhart Wagner
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4. Plasmid rolling-circle (RC) replication
- Prof. Saleem Khan
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5. Replication of linear plasmids in bacteria
- Prof. George Chaconas
- Maintenance and Partitioning
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6. Plasmid segregation and stability in bacteria
- Prof. Barbara Funnell
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7. Plasmid stabilization by cell killing
- Prof. Keith Weaver
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8. Dimer catastrophes and plasmid resolution
- Dr. David Summers
- Conjugation and Mobilization
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9. The diversity of bacterial conjugation and mobilization systems
- Prof. Fernando de la Cruz
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11. DNA processing in conjugative transfer
- Dr. Joel Schildbach
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12. Agrobacterium tumefaciens
- Dr. Stephen Winans
- Genetic Traits Frequently Associated with Plasmids
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13. Insertion sequences and DNA transposition
- Prof. William Reznikoff
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14. Plasmids, integrons and the spread of antibiotic resistance
- Prof. Hatch Stokes
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15. Virulence plasmids
- Prof. Julian Rood
- Eukaryotic Plasmids
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16. The yeast plasmid: a highly persistent selfish DNA element
- Prof. Makkuni Jayaram
- Population Biology and Evolution
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17. Evolution of plasmids and their role in bacterial diversity and adaptability
- Prof. Christopher Thomas
- Archived Lectures *These may not cover the latest advances in the field
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19. Plasmid segregation and stability in bacteria
- Prof. Barbara Funnell
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20. Replication of linear plasmids in bacteria
- Prof. George Chaconas
Printable Handouts
Navigable Slide Index
- Introduction
- What are virulence plasmids?
- Why are they important?
- Types of virulence plasmids
- Virulence plasmids
- Toxin plasmids
- Metabolic plasmids
- Adhesin plasmids
- Other virulence plasmids
- The anthrax toxin plasmids
- Genetic organisation of pXO1
- Role of pXO1 in virulence
- Interaction with host cells
- Genetic organisation of pXO2
- Regulation of toxin genes
- Clostridial toxin plasmids: Clostridium tetani
- Clostridial toxin plasmids: Clostridium perfringens
- The CPE plasmids
- Conjugation locus of C. perfringens toxin plasmids
- Metabolic plasmids to be discussed
- Mycolactone biosynthesis and pMUM001
- pMUM001: a blueprint for mycolactone synthesis
- mls genes are modular
- The pJM1 virulence plasmid of Vibrio anguillarum
- Genetic map of pJM1
- Adhesin plasmids to be discussed
- Enterotoxigenic E. coli infections
- Enteropathogenic E. coli infections
- Genetic map of pB171
- Linear virulence plasmids of Borrelia
- DNA molecules of B. burgdorferi
- Other virulence plasmids to be discussed
- Shigella
- Shigella invasion process
- The entry region on Shigella virulence plasmids
- Mode of action of T3SS
- The Ipa proteins
- Role of IpaA-C in Shigella entry
- Other T3SS effectors
- Other proteins encoded by virulence plasmid
- Yersinia
- Yop plasmids
- Summary
- Acknowledgements
Topics Covered
- Definition and importance of virulence plasmids
- Types of virulence plasmids
- Toxin plasmids
- The anthrax toxin plasmids
- Clostridial toxin plasmids
- Metabolic plasmids
- Mycolactone biosynthesis by Mycobacterium ulcerans
- Iron uptake by Vibrio anguillarum
- Adhesin plasmids
- Enterotoxigenic E. coli: CFA
- Enteropathogenic E. coli: BFP
- Linear plasmids of Borrelia
- Other virulence plasmids
- Shigella: type III secretion system, ipa genes
- Yersinia: type III secretion system, yop genes
- Bacillus anthracis is the causative agent of anthrax
- pXO1 encodes toxin and regulatory genes
- pXO2 encodes capsule and regulatory genes
Links
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Talk Citation
Rood, J. (2008, January 28). Virulence plasmids [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 31, 2024, from https://doi.org/10.69645/GBPR3227.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Julian Rood has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.