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Bone morphogenetic protein (BMP) signaling in drosophila: from germline to early embryogenesis

Published on February 29, 2024   34 min

A selection of talks on Cell Biology

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Hello. My name is Helena Araujo. I'm a professor at the Federal University of Rio de Janeiro in Brazil. Today, I would like to present you a group of signaling molecules of great importance during Drosophila development, the bone morphogenetic proteins or BMPs. Despite the name as given due to their initial characterization in vertebrate bone, we will see that these molecules are utilized in several contexts of Drosophila development, particularly in maintaining the female germ line and in patterning during early embryonic development.
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BMPs are part of the TGFβ superfamily of secreted ligands. They form homo- and heterodimers that bind to serine/threonine kinase transmembrane receptors and elicit intracellular responses. Upon ligand binding, Type I and II heterotrimeric receptors phosphorylate intracellular R-Smads that subsequently bind to co-Smads and translocate to the nucleus to regulate the transcription of target genes. In the extracellular space, the BMPs are regulated by a series of modulators, such as Chordin (Chd) and twisted gastrulation proteins (Tsg) that may inhibit BMPs from binding to their receptors. This delicate balance is also controlled by metalloproteases of the tolloid family, which cleave Chd-like proteins and release BMPs, which are then free to bind to their receptors and regulate processes as diverse as cell division, survival, and differentiation. One important aspect of BMP proteins
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Bone morphogenetic protein (BMP) signaling in drosophila: from germline to early embryogenesis

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