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- Introduction to Protein Structure and Function
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1. Nature’s strategies in the regulation of enzyme activity by modifiers
- Prof. Antonio Baici
- Creation of Protein Variability by Manipulation of Genes
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3. Perspectives on biological catalysis
- Prof. Stephen Benkovic
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4. Fundamentals and principles for engineering proteolytic activity
- Prof. Charles Craik
- Metabolic Diseases Caused by Genetic Mutation
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5. Modifications of pyruvate handling in health and disease
- Prof. Mary Sugden
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6. Mitochondrial fatty acid oxidation deficiencies
- Prof. Niels Gregersen
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7. Inborn errors of ketone body metabolism
- Prof. Toshiyuki Fukao
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8. Cathepsin K in bone and joint diseases
- Prof. Dieter Bromme
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9. Fabry disease: alfa-galactosidase A deficiency and enzyme replacement therapy
- Prof. David Warnock
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10. Acid beta-glucosidase/glucocerebrosidase (GCase)
- Prof. Gregory Grabowski
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11. GM2 gangliosidosis future treatments 1
- Prof. Brian Mark
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12. GM2 gangliosidosis future treatments 2
- Prof. Brian Mark
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13. The neuronal ceroid lipofuscinoses
- Prof. Sandra Hofmann
- Disorders of Blood Coagulation
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14. Advances in fibrinolysis
- Dr. Paul Kim
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16. Structure of thrombin, a Janus-headed proteinase
- Prof. Wolfram Bode
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18. Fibrinogen and factor XIII
- Prof. John Weisel
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19. Factor VIII and haemophilia A
- Dr. Geoffrey Kemball-Cook
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20. Factor IX
- Prof. Bruce Furie
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21. The biology and pathobiology of von Willebrand factor
- Prof. David Lillicrap
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22. Thrombotic thrombocytopenic purpura
- Prof. J. Evan Sadler
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23. Fibrinolysis
- Prof. Edward Tuddenham
- Other Molecular and Metabolic Disorders
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24. Glucose-6-phosphate dehydrogenase deficiency
- Dr. Jane Leopold
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25. Cytochrome b5 reductase deficiency and hereditary methemoglobinemia
- Dr. Scott Reading
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26. Sickle cell disease
- Prof. Martin H. Steinberg
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27. Pyruvate kinase deficiency
- Prof. Alberto Zanella
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28. Heritable disorders of collagen
- Dr. Heather Yeowell
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29. Duchenne muscular dystrophy
- Prof. Jeff Chamberlain
- Archived Lectures *These may not cover the latest advances in the field
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30. Protein crystallography
- Prof. Michael James
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31. Regulation of blood coagulation by the serpin, antithrombin
- Prof. Steve Olson
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32. Rhodopsin and retinitis pigmentosa
- Dr. Shalesh Kaushal
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33. The physiology and pathology of coagulation factor XI
- Dr. David Gailani
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34. Cytochrome b5 reductase deficiency and hereditary methemoglobinemia
- Prof. Josef Prchal
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35. Metachromatic leukodystrophy
- Prof. Volkmar Gieselmann
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36. Serpins and serpinopathies
- Dr. James Whisstock
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38. Pleiotropic and epistatic genes in sickle cell anaemia
- Prof. Ronald Nagel
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39. Genetic disorders of carbonic anhydrases II and IV
- Prof. William Sly
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40. GM2 gangliosidoses
- Prof. Don Mahuran
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41. Kinetic analysis of protein activity
- Prof. Antonio Baici
Printable Handouts
Navigable Slide Index
- Introduction
- Learning objectives
- Blood coagulation - primitive defence mechanism
- Vertebrate blood coagulation
- Blood coagulation is conserved in evolution
- Recurrent themes in blood coagulation
- The "resting" state
- The procoagulant response - initiation
- The coagulation response - propagation
- Key points - coagulation initiation and propagation
- Regulation of coagulation network
- Key points - anticoagulant response
- Coagulation regulation and molecular pathology
- Key points - bleeding and thrombotic disorders
- Tissue factor (TF)
- Sites of TF expression - "haemostatic envelope"
- Molecular pathology associated with TF
- Agents known to induce TF expression (in vitro)
- TF is rapidly induced
- Factor VII
- FVII deficiency
- Frequency of mutations
- Distribution of the mutations along the gene
- FVII deficiency - example
- Direct DNA sequence analysis (1)
- Direct DNA sequence analysis (2)
- Molecular modelling of FVII G117R mutation
- Species comparison of mutated sequence
- Prenatal diagnosis
- TFPI
- Key points - TFPI
- Summary
Topics Covered
- Tissue factor and factor VII
- Initiation of blood coagulation
- Vertebrate blood coagulation
- The resting state
- The procoagulant response
- The anticoagulant response
- Molecular pathology
- Tissue factor
- Factor VII
- Tissue factor pathway inhibitor
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
McVey, J. (2015, December 15). Tissue factor and factor VII: initiation of blood coagulation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 31, 2024, from https://doi.org/10.69645/FBHU8267.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. John McVey has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Tissue factor and factor VII: initiation of blood coagulation
A selection of talks on Clinical Practice
Transcript
Please wait while the transcript is being prepared...
0:00
The title of this module is Tissue Factor and
Factor VII -.Initiation of Blood Coagulation.
My name is John McVey.
0:09
The learning objectives are to introduce the coagulation network,
to give you an understanding of how this complex process is regulated,
and how it functions at the molecular level.
In particular, focusing on the role of Tissue Factor and
Factor VII complex in initiating coagulation,
looking at their structure and function but also the role of tissue factor
pathway inhibitor and regulating the activity of this initiation complex.
Finally, I will discuss the pathophysiological consequences of
inappropriate expression or deficiency.
0:43
The ability to stem the flow of body fluids at the sight of
vascular injury is a very primitive defense mechanism.
This is critical for the survival of any multicellular organism,
both in preventing loss but also preventing entry of organisms and pathogens.
Organisms have adopted a variety of
different methods to achieve this, tissue contraction,
cellular aggregation, and the formation and deposition of molecular glues.
1:10
Vertebrates have evolved a complex system that includes blood vessel
constriction, cellular aggregation involving specialized cells,
platelets, and the deposition of an insoluble polymer fibrin,
that results in the formation of a stable clot at the site of injury.
In this scanning electron micrograph,
you can see the fibrin mesh work in trapping red and white blood cells.
Although this teaching session will focus on
the processes that regulate the initiation of
coagulation leading to Thrombin generation and the formation of a stable fibrin clot,
it should be appreciated that the process of
platelet activation and Thrombin generation are intimately linked.
Platelets provide a surface for the promotion and assembly of
procoagulant complexes and a source of coagulation factors.
Conversely, Thrombin is a potent activator of platelets.