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2. Diabetes through the ages
- Dr. Michael Stephen Hall
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3. Evolution of diagnostic criteria for diabetes
- Prof. Mayer Davidson
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4. Diagnosis and screening of diabetes
- Prof. Jonathan Shaw
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5. The treatment of type 1 diabetes in children and youth
- Prof. Francine Kaufman
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6. What is new in type 1 diabetes?
- Prof. Åke Lernmark
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7. Autoimmune diabetes in adults: current evidence and controversies
- Prof. Richard David Leslie
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8. Type 2 diabetes
- Prof. Edward Boyko
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9. Inflammation in type 2 diabetes and associated disease
- Prof. Marc Y. Donath
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10. Pre-gestational diabetes and pregnancy
- Prof. Jeremy J. N. Oats
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11. Understanding and managing gestational diabetes
- Prof. Jeremy J. N. Oats
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12. Gene-environment interactions in complex disease
- Prof. Paul Franks
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13. Diabetes and heart disease
- Prof. Trevor J. Orchard
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14. The eye and diabetes
- Prof. Tien Wong
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15. The metabolic syndrome
- Prof. Jean Pierre Després
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16. Physical activity, sedentary behavior and diabetes
- Prof. David Dunstan
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17. Cardiovascular prevention in type 2 diabetes
- Prof. Eberhardt Standl
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18. Economic and social cost of diabetes
- Dr. Ping Zhang
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19. Diabetes biomarkers
- Prof. Naveed Sattar
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20. Type 1 diabetes: control and complications trials
- Prof. John Petrie
- Archived Lectures *These may not cover the latest advances in the field
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21. Latent autoimmune diabetes in adults
- Prof. Richard David Leslie
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22. Inflammation and type 2 diabetes
- Prof. Marc Y. Donath
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23. What is new in type 1 diabetes?
- Prof. Åke Lernmark
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24. Diabetes through the ages
- Dr. Michael Stephen Hall
Printable Handouts
Navigable Slide Index
- Intorduction
- 100 years of insulin
- Leonard Thompson
- Evolution in diabetes treatments
- In antiquity
- Searching for the cause
- The islet cells in the pancreas
- Oskar Minkowski and Joseph von Mering
- Link between the pancreas and diabetes
- Linking the pancreas to diabetes
- Eugene Opie
- George Ludwig Zuelzer
- Ernest Lyman Scott
- Nicolae Paulescu
- Paulescu publishes his findings
- The role of chance
- Macleod & chance
- Treatments before insulin
- The Nobel Prize controversy (1)
- The Nobel Prize controversy (2)
- The Allen diet
- Dr. Elliott P Joslin
- The two key players in 1920 in Canada
- JJR Macleod
- Frederick Banting
- Banting’s notes
- The start of Banting’s research adventure
- Banting’s great idea
- In summary – Banting’s idea
- He was excited by his idea!
- What was “decided” at the meeting
- To do or not to do
- Charles Best
- The plan for the research
- Difficulties
- But optimism ruled, a glimmer of success
- But in fact
- And another idea
- Matters quickly moved forwards
- James B Collip
- Publication!
- Banting pushes for a clinical trial
- A clinical trial?
- Leonard Thompson
- Quarrels and rewards
- A famous case
- Elizabeth Hughes
- “Unspeakably wonderful”
- Manufacturing
- Insulin around the world
- Dr. R D Lawrence
- Dr. Ernesto Roma
- The Nobel Prize for Physiology or Medicine
Topics Covered
- Story of diabetes
- Treatments before insulin
- Linking the pancreas to diabetes
- Frederick Banting and John Macleod discovered insulin
- Co-discoverers of insulin; Charles Best and Bertram Collip
- The first injection of insulin to Leonard Thompson
- Manufacturing of insulin
- Nobel Prize for the discovery of insulin to Banting and Macleod
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Hall, M.S. (2023, April 30). Diabetes through the ages [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 1, 2024, from https://doi.org/10.69645/IUZC9704.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Michael Stephen Hall has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Cardiovascular & Metabolic
Transcript
Please wait while the transcript is being prepared...
0:00
I'm going to be speaking to you
about diabetes through the ages.
My name is Michael Hall.
For many years, I
was involved with
Diabetes UK and also
with the International
Diabetes Federation.
Though my original background
was general practice,
my research interests
were diabetes.
0:24
It's now just over
100 years since
the discovery of insulin
by the Toronto team,
and it is appropriate
to look forwards and
consider whether we can at last
perhaps see a cure for type
1 diabetes on the horizon.
It has long been promised.
Hundreds of millions of dollars
have been invested in research,
and now perhaps
there's hope with
the coming developments
in immunotherapy,
which may halt
the immune system's
attacks on the pancreas.
0:59
The first person to receive
insulin was Leonard Thompson.
He was admitted on the
2nd of December, 1921,
under the care of
Dr. Walter Campbell,
who ran a diabetic clinic in
Toronto under the
supervision of Prof. Graham.
Thompson had been on
the Allen Starvation
regime for over two years,
and was now in the
terminal phase.
His father agreed to let
the hospital try Banting
and Best's new pancreatic
extract for the first time.
1:35
Since then, amazing
advances have led to
many different devices
which assist those with
type 1 diabetes to receive
their insulin in a safe
and calibrated way via
pumps, which at one
extreme can be set to give
an automatically
calculated accurate dose.
The basic insulin syringes
have been improved,
allowing accurate and virtually
pain-free injections
to be given.
For those with type 2 diabetes,
care systems have been
developed and
medication improved,
enabling care quality
to be enhanced.
Our understanding of
the importance of diet,
calorie control, and weight
reduction has also improved.
For some with type 2 diabetes,
education and lifestyle changes
allow the condition to be
controlled so that diabetes is
reversed, effectively, cured.