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- Perspective and Pathogenesis
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1. Expanding frontiers of cerebrovascular disease
- Prof. Vladimir Hachinski
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2. Basic anatomy, physiology and pathophysiology of the cerebral circulation for the physician
- Prof. Jean-Claude Baron
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3. Pathophysiology of cerebral ischemia
- Prof. Wolf-Dieter Heiss
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4. Intracerebral hemorrhages: causes and clinical findings
- Prof. Louis Caplan
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5. Subarachnoid hemorrhage (SAH)
- Prof. R. Loch Macdonald
- Diagnosis
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6. Clinical diagnosis of stroke and subtypes
- Prof. Louis Caplan
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7. The investigation of stroke
- Dr. Bart Demaerschalk
- Treatment
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8. Acute therapy of stroke and reperfusion treatments
- Prof. Brian Silver
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9. Subarachnoid hemorrhage diagnosis and management
- Prof. Gary K. Steinberg
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10. Stroke-induced heart injury
- Dr. Luciano A. Sposato
- Rehabilitation
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11. Stroke rehabilitation: principles of stroke
- Prof. Robert Teasell
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12. Stroke rehabilitation: therapies and treatments
- Prof. Robert Teasell
- Prevention
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13. Lifestyle and nutrition in stroke prevention
- Prof. J. David Spence
- Special Topics
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15. Pediatric stroke: cerebrovascular injury in the developing brain
- Prof. Adam Kirton
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16. Stroke in women: epidemiology, risk and prevention
- Prof. Cheryl Bushnell
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17. Transient ischemic attack and cognition
- Dr. Jennifer Mandzia
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18. Vascular cognitive impairment
- Prof. Eric E. Smith
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19. Atrial fibrillation, anticoagulation and vitamins for homocysteine
- Prof. J. David Spence
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20. Stroke in the young adult
- Prof. Jeffrey Saver
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21. Stroke in the young
- Dr. Gyan Kumar
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22. Convergence and joint prevention of stroke and dementia
- Prof. Vladimir Hachinski
- Archived Lectures *These may not cover the latest advances in the field
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23. Vascular cognitive impairment
- Dr. John Bowler
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24. Pediatric stroke
- Dr. Gabrielle deVeber
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25. The deteriorating stroke
- Prof. Werner Hacke
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26. General management
- Prof. Bo Norrving
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27. The treatment of stroke: specific management - thrombolysis plus
- Prof. Nils Wahlgren
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28. Rehabilitation: the chronic phase
- Prof. Lalit Kalra
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29. Prevention: management of risk and protective factors
- Prof. Graeme Hankey
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30. Medical therapy for secondary prevention of ischemic stroke
- Prof. Larry Goldstein
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31. Subarachnoid haemorrhage
- Prof. Jan van Gijn
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32. Controversies in stroke
- Prof. Stephen Davies
- Prof. Geoffrey Donnan
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33. Medical and surgical stroke
- Prof. Carlos Kase
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34. The urgency of stroke prevention after TIA
- Prof. S. Claiborne Johnston
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35. Carotid endarterectomy, angioplasty and stenting
- Prof. Martin Brown
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36. The clinical diagnosis of stroke and stroke subtypes
- Prof. Louis Caplan
Printable Handouts
Navigable Slide Index
- Introduction
- Objectives
- What is a TIA: Definition of TIA
- TIA can be difficult to diagnose: Mimics (30–50%)
- What occurs during a TIA at a cerebral hemodynamic and cellular level?
- MR DWI + lesions are common after “TIA” and are associated with duration of symptoms
- Significance of DWI lesions in TIA patients
- Why is a diagnosis of TIA important: Opportunity to intervene
- TIA/minor stroke patients evaluated by stroke specialists have lower rate of recurrent events
- Cognitive dysfunction following stroke
- Concept of Vascular Cognitive Impairment (VCI)
- Why would a TIA result in cognitive impairment?
- Cognitive impairment following TIA
- What neuropsychological tests should be used to examine cognitive impairment in TIA patients?
- MOCA is useful in detecting MCI at 1-year post-stroke/TIA
- Imaging factors associated with increased risk of cognitive dysfunction following stroke
- Imaging and baseline predictors of cognitive dysfunction in minor stroke and high-risk TIA
- Long term effects of TIA and minor stroke on brain atrophy compared to normal controls
- Does transient brain hypoperfusion lead to structural brain changes in TIA patients?
- Limitations of previous studies
- Future questions and directions
- Summary
Topics Covered
- Definition and explanation of a transient ischemic attack (TIA)
- Stroke and dementia
- Symptoms associated with TIA
- Cognitive dysfunction
- Cognitive deficits and imaging following TIA
Links
Series:
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Therapeutic Areas:
Talk Citation
Mandzia, J. (2021, April 28). Transient ischemic attack and cognition [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 1, 2024, from https://doi.org/10.69645/LZWC3057.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
A selection of talks on Neuroscience
Transcript
Please wait while the transcript is being prepared...
0:00
My name is Jennifer Mandzia.
I'm an assistant professor from Western University,
the Department of Clinical Neurosciences in London,
and the Co-medical Director of the Stroke Program here at
London Health Sciences and in Southwestern Ontario Stroke Network in Canada.
Today I'm going to be talking about transient ischemic attack and cognition.
0:25
The objectives today, I am going to start by
defining what is a transient ischemic attack.
Then I'm going to discuss the relationship between cerebrovascular disease and cognition.
Then I will be discussing how cognition is
affected in patients who have had a transient ischemic attack.
Then last, discussing the factors that can
influence and mediate cognitive dysfunction in TIA.
0:55
So what is a TIA?
A transient ischemic attack was traditionally defined, and somewhat arbitrary,
as a focal cerebral ischemic event of the brain or
the retina with symptoms lasting less than 24 hours.
When I say arbitrary,
the duration was defined quite arbitrarily as less than 24 hours.
However, in 2009, a new definition of
TIA was proposed to improve upon the traditional definition,
especially pertaining to the duration of TIAs,
which typically last between 10 minutes to one hour in duration.
So the new definition proposed was a transient episode of neurological dysfunction, caused by
focal brain or spinal cord or
retinal ischemia without an acute infarction seen on imaging.