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- Systems Biology in Molecular and Cellular Biology
-
1. Integrated view on a eukaryotic osmoregulation system
- Prof. Stefan Hohmann
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2. Systems biology of the cell cycle
- Prof. Bela Novak
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3. Interactome networks and human disease
- Prof. Marc Vidal
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4. Control feedback and cellular responses
- Prof. Francis J. Doyle III
- Systems Biology in Metabolism
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5. Impact of systems biology on metabolic engineering
- Prof. Jens Nielsen
- Computational Concepts in Systems Biology
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6. Systems biology graphical notation (SBGN)
- Prof. Huaiyu Mi
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7. Garuda platform: re-imagining connectivity in medicine
- Dr. Samik Ghosh
-
8. A versatile platform for multilevel modeling of physiological systems
- Dr. Yoshiyuki Asai
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9. A systems biology approach to oncology drug development
- Dr. Birgit Schoeberl
- Systems Biology in Development and Diseases
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11. A systems approach to implementation of personalized cancer therapy
- Prof. Gordon B. Mills
- Applications of Systems Biology in Drug Discovery and Biotechnology
Printable Handouts
Navigable Slide Index
- Introduction
- Osmoregulation
- Osmotic stress and adaptation
- Cell compression retards molecular processes (1)
- Cell compression retards molecular processes (2)
- Yeast osmoadapts via glycerol accumulation
- Glycerol metabolism
- High Osmolarity Glycerol (HOG) signalling
- HOG signalling and glycerol metabolism
- Post-osmotic shock HOG activation is transient
- HOG feedback control (1)
- HOG feedback control (2)
- Different control mechanisms (1)
- Different control mechanisms (2)
- Investment in adaptation
- Different control mechanisms (3)
- HOG pathway: one of four yeast MAPK pathways
- Sequential activation of three MAPKs in yeast (1)
- Osmo-adapted cells treated with pheromone
- Hog1 activation depends on Slt2 and Fps2
- Sequential activation of three MAPKs in yeast (2)
- Rewiring osmoadaptation (1)
- Rewiring osmoadaptation (2)
- Rewiring osmoadaptation (3)
- Rewiring osmoadaptation (4)
- Conclusions
- Acknowledgements
Topics Covered
- Osmoregulation
- Cell compression and macromolecular crowding
- Osmolyte accumulation
- Metabolism and signalling
- Modelling, simulation and prediction
- Multi-level control of osmolyte accumulation
- Mitogen activated protein kinase signalling
- Signalling crosstalk
- Synthetic biology approaches to osmoregulation
Talk Citation
Hohmann, S. (2014, November 4). Integrated view on a eukaryotic osmoregulation system [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 31, 2024, from https://doi.org/10.69645/EMIC3276.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Stefan Hohmann has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Methods
Transcript
Please wait while the transcript is being prepared...
0:00
My
name is Stefan Hohmann,
and I am a professor in
molecular microbial physiology
at the Department of Chemistry
and Molecular Biology
at the University of
Gothenburg in Sweden.
I'm going to present
today an integrated
view on a eukaryotic
osmoregulation system.
My group, as well as a number
of groups all over the world,
have been working on osmoregulation
and the osmotic stress response
in the model organism,
yeast saccharomyces
cerevisiae for the
last about 25 years.
The integrated view that
I'm going to present today
is the result of both experimental
studies using genetics,
molecular biology, and
metabolomics, combined
with this theoretical studies using
mathematical models and simulations
and predictions using those models.
0:55
What is osmoregulation?
Osmoregulation is an active process.
It is the active regulation of
the osmotic homeostasis of a cell
or also of an entire organism,
although my talk will mainly focus
on a osmotic homeostasis
of single cells
the yeast, saccharomyces cerevisiae.
So what are the main
purposes of osmoregulation?
One purpose is to maintain the
sense cell's turgor pressure,
and therefore the shape
and the volume of cells.
So in that sense, regulation
has a significant role
in cell morphology.
Osmoregulation also controls
the cell's water content
and hence keeps the cell's fluids
from becoming either too diluted
or from becoming too concentrated.
And I will come back to
that point in a few moments.
Homeostasis is
something static, so it
is difficult to study, actually,
because of that reason.
So therefore, regulation is very
commonly observed as the adaptation
to a osmotic stress.
So the response of
cells to rapid changes
in the osmotic conditions
of the environment.