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1. Historic introduction to innate immunity
- Prof. Heiko Herwald
- Prof. Arne Egesten
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2. Evolution of innate immunity
- Prof. Jim Kaufman
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3. The phagocytic synapse in distinguishing particulate and soluble stimuli
- Prof. David Underhill
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4. How bacterial pathogens avoid phagocyte killing
- Dr. Thomas Areschoug
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5. Origin of myeloid cells
- Prof. Frederick A. Geissmann
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6. Dendritic cells
- Prof. Muriel Moser
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7. Eosinophil biology and disorders associated with eosinophilia
- Dr. Thomas B. Nutman
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8. CD1d-restricted NKT cells: regulators of inflammation and autoimmunity
- Prof. Steven A. Porcelli
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9. Innate-like B cells
- Prof. John F. Kearney
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10. Cytoplasmic innate immune sensors
- Prof. Seth Masters
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12. The role of myeloid cells in HIV associated immune reconstitution inflammatory syndrome
- Prof. Robert Wilkinson
- Prof. Graeme Meintjes
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13. Antimicrobial peptides in the innate immune system of the lung
- Prof. Dr. Pieter S. Hiemstra
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14. Chemokines and their receptors: their biology and therapeutic relevance
- Dr. Amanda Proudfoot
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15. Heat shock proteins and their role in the immune regulation of inflammation
- Prof. Willem Van Eden
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16. Tissue damage control confers host tolerance to infection
- Dr. Miguel P. Soares
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17. Autophagy as a barrier to infection
- Prof. Michele Swanson
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18. Innate immunity in the intestine in health and disease
- Prof. Kevin Maloy
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19. Dendritic cells and the eye: their role in the ocular immune response
- Prof. John V. Forrester
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20. Mononuclear phagocytes and HIV infection
- Dr. Guido Poli
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21. Th17 cells and innate immunity
- Prof. Mihai Netea
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22. Epigenetic regulation of innate immunity
- Dr. Osamu Takeuchi
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23. Intracellular DNA sensing pathways
- Prof. Veit Hornung
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24. Physiology of innate immunity
- Prof. Keith W. Kelley
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26. Regulation of type 2 immunity by basophils
- Prof. David Voehringer
- Archived Lectures *These may not cover the latest advances in the field
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27. TLRs, NLRs, DAMPs and PAMPs
- Prof. Luke O'Neill
Printable Handouts
Navigable Slide Index
- Introduction
- The HIV pandemic - 2010
- HIV structure
- HIV targets cells express CD4 & CCR5 or CXCR4
- The HIV life cycle
- Macrophages as "Trojan horses" of HIV virions
- HIV infection of T cells and macrophages
- Mononuclear phagocytes differentiation & HIV
- HIV infects bone marrow MP precursors in vitro
- HIV Infects bone marrow MP precursors in vivo
- HIV affects the function of circulating monocytes
- HIV infects circulating monocytes
- HIV & tissue macrophages
- HIV & the brain
- Intestinal macrophages don't express HIV Co-R
- Intestinal macrophages are not infectible by HIV
- Intestinal vs. blood macrophages
- HIV replication in myelo-monocytic cell lines
- Promonocytic U937 & U1 cell lines (1)
- Promonocytic U937 & U1 cell lines (2)
- Inhibition of HIV-1 replication in minus U937 cells
- Differential expression of HMGB1-R in U937 cells
- Only minus U937 cell clones express TRIM22
- Promonocytic U937 & U1 cell lines (3)
- Differential effect of IFN-alpha and IFN-gamma (1)
- Differential effect of IFN-alpha and IFN-gamma (2)
- Does polarization influence susceptibility to HIV?
- Human macrophages can be polarized
- Polarization of monocyte-derived macrophages
- M1 and M2a polarization inhibits HIV-1 replication
- Functional differences between M1 and M2 MDM
- Differential inhibitory effects of M1 vs. M2 on HIV-1
- Conclusions
- Acknowledgments
Topics Covered
- The HIV pandemic
- HIV structure
- HIV target cells and their viral receptors
- HIV life cycle
- Macrophages as "Trojan horses" of HIV
- Comparison of HIV infection of T cells and macrophages
- Macrophage differentiation
- HIV infection of bone marrow precursors in vitro and in vivo
- Functional defects of monocytes
- HIV and tissue macrophages
- HIV and the brain
- HIV and intestinal macrophages
- HIV replication in monocytic cell lines
- U937 and U1 cell lines
- HMGB1 and HIV infection of U937 cells
- U937 cell clones and TRIM22
- IFNs and HIV infection of macrophages
- Human macrophage polarization and HIV infection
- Macrophage polarization and inhibition of HIV replication
- Differences between M1 and M2 macrophages in inhibiting HIV replication
Links
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Talk Citation
Poli, G. (2012, April 3). Mononuclear phagocytes and HIV infection [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 13, 2024, from https://hstalks.com/bs/2284/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Guido Poli has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.