• Overview of Chaperone Networks
• 41 min
  1. Mapping the molecular chaperone interaction network in yeast

  • Prof. Walid A. Houry
• 30 min
  2. The interaction network of the GroEL chaperonin

  • Prof. Dr. F. Ulrich Hartl
• 61 min
  3. Human heat shock protein families

  • Prof. Herman Kampinga
• 42 min
  4. Extracellular proteostasis: an emerging field

  • Prof. Mark Wilson
• 36 min
  5. Protein homeostasis and the chaperone interaction network in Arabidopsis thaliana

  • Prof. Rongmin Zhao
• Proteasome Networks
• 64 min
  6. Biogenesis of the eukaryotic proteasome

  • Prof. Mark Hochstrasser
• Understanding Intrinsically Disordered Proteins in Protein Homeostasis
• 36 min
  7. Intrinsically unstructured proteins: regulation and disease

  • Dr. M. Madan Babu
• 43 min
  8. The roles of intrinsic disorder in protein interaction networks

  • Prof. Vladimir N. Uversky
• Gene Regulatory Networks and their Role in Protein Homeostasis
• 38 min
  9. Network motifs: basic building blocks of biological networks

  • Prof. Uri Alon
• 41 min
  10. Structure, evolution and dynamics of gene regulatory networks

  • Dr. M. Madan Babu
• 33 min
  11. Computational methods in analysis of gene regulation and protein interactions

  • Prof. Ron Shamir
• 51 min
  12. Protein-protein interaction networks

  • Prof. Peter Csermely
• Protein Homeostasis in the Endoplasmic Reticulum
• 56 min
  13. Role of calnexin and calreticulin in protein homeostasis within the endoplasmic reticulum

  • Prof. David B. Williams
• 30 min
  14. The unfolded protein response

  • Prof. Kazutoshi Mori
• 38 min
  15. Role of ER stress in cystic fibrosis airway inflammation

  • Dr. Carla Maria Pedrosa Ribeiro
• 57 min
  16. The recognition of misfolded glycoproteins in the endoplasmic reticulum

  • Dr. David Y. Thomas
• 49 min
  17. Chaperone systems of the endoplasmic reticulum

  • Prof. Linda M. Hendershot
• 74 min
  18. The ERAD network

  • Prof. Daniel Hebert
• Protein Homeostasis in the Mitochondria
• 22 min
  19. Protein homeostasis in mitochondria: AAA+ chaperones & proteases

  • Dr. David A. Dougan
• 46 min
  20. Protein homeostasis in mitochondria: chaperones and proteases of the mitochondrial matrix

  • Prof. Wolfgang Voos
• 26 min
  21. Mitochondrial chaperonin Hsp60: locations, functions and pathology

  • Prof. Francesco Cappello
  • Prof. Alberto J. L. Macario
• Protein Homeostasis in the Nucleus
• 23 min
  22. Nuclear protein quality control degradation

  • Dr. Richard G. Gardner
• Protein Homeostasis in Aging Disease
• 27 min
  23. Protein homeostasis during ageing: C. elegans as a model organism

  • Prof. Nektarios Tavernarakis
• Protein Homeostasis in Neurodegeneration
• 41 min
  24. Endoplasmic reticulum stress in neurodegenerative diseases

  • Prof. Claudio Soto
• 48 min
  25. Roles for Hsp40 molecular chaperones in protein misfolding disease

  • Prof. Douglas M. Cyr
• 38 min
  26. Protein folding in vivo

  • Prof. James Bardwell
• 39 min
  27. Protein degradation and defense against neurodegenerative disease 1

  • Prof. Alfred Goldberg
• 42 min
  28. Protein degradation and defense against neurodegenerative disease 2

  • Prof. Alfred Goldberg

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Neurodegenerative disease (1)
3. Neurodegenerative disease (2)
4. Neurodegenerative disease (3)
5. What causes neurodegenerative diseases?
6. Misfolded aggregates deposited in the brain
7. Role of protein aggregates in disease
8. Research strategy
9. Prion diseases
10. Two conformations of the prion protein
11. Brain alterations in prion diseases
12. Experimental scrapie model in mice
13. Sequence of events in scrapie pathogenesis
14. ERp57 upregulation
15. ERp57 and PrPSc correlation in the brain
16. Upregulation of other ER chaperones
17. ER-stress and UPR in human CJD
18. The UPR pathway
19. XBP-1 conditional KO did not affect prion disease
20. PrP interaction with ER chaperones in brain
21. PrPSc induces neuronal death in vitro
22. PrPSc induces ER-stress in vitro
23. Prion infection sensitizes cells to ER-stress
24. Calcium release comes from the ER
25. Hypothesis: Prion formation leads to ER stress
26. Calcineurin properties
27. Signaling pathways
28. Calcineurin is implicated in PrPSc toxicity
29. A novel treatment for prion diseases
30. Treatment improves symptoms (behavior)
31. Treatment increases animal survival
32. FK506 effect on calcineurin and its targets
33. Treatment decreases neuronal death
34. Treatment decreases neurodegeneration
35. Conclusions
36. Acknowledgment
37. Former lab members

Topics Covered

• Neurodegenerative disease
• Misfolded aggregates deposited in the brain
• Research strategy
• Prion diseases
• Two conformations of the prion protein
• Experimental scrapie model in mice
• Upregulation of ER chaperones
• ER-stress and UPR in human CJD
• PrP interaction with ER chaperones in brain
• PrPSc induction of ER-stress and neuronal death
• Calcineurin properties
• A novel treatment for prion diseases

Links

Series:

• Protein Homeostasis

Categories:

• Biochemistry
• Cell Biology
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on February 2, 2012

Financial Disclosures

• Prof. Claudio Soto has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.