• Introduction
• 38 min
  1. DNA methylation during development

  • Prof. Howard Cedar
• The Nuts and Bolts of DNA Methylation
• 54 min
  2. DNA methylation patterns in mammals

  • Prof. John Greally
• 31 min
  3. Proteins that bind methylated DNA

  • Dr. Pierre-Antoine Defossez
• DNA Methylation and Normal Physiology
• 25 min
  4. Genomic imprinting

  • Prof. Marisa Bartolomei
• 32 min
  5. DNA methylation and stem cells

  • Dr. Alexander Meissner
• DNA Methylation and the Pathophysiology of Disease
• 54 min
  6. DNA methylation changes in aging cells and tissues

  • Prof. Jean-Pierre Issa
• 61 min
  7. DNA methylation in cancer

  • Prof. Paula Vertino
• 29 min
  8. Epigenomics of complex disease

  • Prof. Art Petronis
• 41 min
  9. DNA methylation, inflammation and cancer

  • Prof. Gerd Pfeifer
• Clinical Applications of DNA Methylation Research
• 41 min
  10. DNA methylation as a tumor marker: implications for diagnosis, early detection and risk assessment

  • Prof. Steve Belinsky
• 46 min
  11. Reversing DNA methylation pharmacologically

  • Dr. Allen Yang

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Epigenetics
3. Epigenetics: phenotypic variation (1)
4. DNA methylation in context
5. DNA methylation - promoter CpG islands
6. DNA Methylation - promoter Non-CpG islands
7. The methylome
8. DNA methylation changes in aging (1)
9. Global hypomethylation during aging
10. Decrease in methylation in aging cells
11. DNA methylation changes in aging (2)
12. Hypermethylation and silencing
13. ER-alpha methylation and age in normal colon
14. Methylation in normal colon vs. age
15. Microarray analysis of aging human colon
16. Methylation in aging human prostate
17. ER-beta methylation vs. age in human right atrium
18. MCAM analysis of aging mouse colon
19. Pyro analysis of aging mouse colon
20. Age related methylation along the GI tract
21. Age related methylation is tissue specific
22. Studies in the field
23. Epigenetic mosaicism
24. Epigenetics: phenotypic variation (2)
25. Epigenetic mosaicism in aging stem cells
26. Human carcinogenesis as an epigenetic disease
27. Changes in tissue function
28. Variability across the population
29. Distribution of ER methylation in normal colon
30. Epigenetic variation in human colon
31. Variability across the genome
32. Susceptibility to DNA hypermethylation
33. DNA hypermethylation and retrotransposons
34. Genome-wide analysis of methylation proneness
35. Genome architecture predicts hypermethylation
36. Repeat element and age related methylation
37. Polycomb targets and hypermethylated genes
38. Retrotransposons & polycomb predict methylation
39. Age related methylation - summarizing model
40. Summary
41. Acknowledgements

Topics Covered

• Epigenetics
• Phenotypic variation
• DNA methylation
• Promoter CpG & Non CpG islands
• The methylome
• DNA methylation changes in aging
• Hypermethylation and silencing
• Methylation in normal colon vs. age
• Microarray analysis of aging human colon
• Methylation in aging human prostate
• Methylation vs. age in human right atrium
• MCAM analysis of aging mouse colon
• Pyro analysis of aging mouse colon
• Age related methylation along the GI tract
• Epigenetic mosaicism
• Human carcinogenesis as an epigenetic disease
• Changes in tissue function
• Tissue function consequences of DNA methylation changes in aging
• Epigenetic variation in human colon
• Susceptibility to DNA hypermethylation
• DNA hypermethylation and retrotransposons
• Genome-wide analysis of methylation proneness
• Genome architecture and the prediction of hypermethylation
• Repeat element distribution and age-related methylation
• Polycomb targets and hypermethylated genes in aging

Links

Series:

• DNA Methylation

Categories:

• Cell Biology
• Genetics & Epigenetics

Talk Citation

Publication History

• Published on February 2, 2011

Financial Disclosures

• Prof. Jean-Pierre Issa has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.