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1. Introduction
2. Chromosomes of a human male: 46,XY
3. The Y chromosome is dominantly sex-determining
4. Ovary or testis?
5. Specialized for sex
6. The human sex chromosomes
7. Evolution of the sex chromosomes
8. Pseudoautosomal region 1 (PAR1)
9. XY pairing in pachytene
10. A gradient of recombination in PAR1
11. Pseudoautosomal region 2
12. Sex-chromosomal recombination
13. Identifying the testis-determining factor
14. Translocation XX males and XY females
15. Principle of deletion mapping the TDF interval
16. Sex-determining region Y (SRY)
17. Evidence that SRY is TDF
18. Randy the transgenic mouse
19. The SRY gene and protein
20. The sex-determining pathway downstream of SRY
21. Turner syndrome
22. Turner syndrome (45,X) phenotype
23. Turner syndrome and X-linked genes
24. Turner syndrome - candidate genes
25. XY-homology
26. Y-chromosomal aneuploidies
27. A high mutation rate on the Y
28. The weird genomic landscape of the Y
29. Y-linked inheritance
30. Other Y-associated phenotypes?
31. Y-linked deafness (DFNY1)
32. The human Y carries fertility factors
33. Testis histologies in normal and infertile males
34. Finding AZF candidate genes
35. AZF phenotypes and candidate genes
36. Genomic disorders
37. NAHR in AZFa and AZFc infertility
38. The 'hall of mirrors'
39. Complex structural rearrangements
40. Substrates for gene conversion
41. Gene conversion is biased
42. 'Genetic coherence' of the Y
43. PAR1 shows no 'genetic coherence'
44. A single ancestor for the Y
45. Genome segments and effective population sizes
46. Y haplogroup distribution
47. Applications of Y diversity
48. Thanks

Topics Covered

• Role in sex determination
• Recombination behaviour
• Sex-chromosomal aneuploidies
• Type and number of genes
• Rates and types of mutation
• Associated diseases
• Sequence organization
• Diversity of Y chromosome types in populations

Links

Series:

• Introduction to Human Genetics

Categories:

• Genetics & Epigenetics

Talk Citation

Publication History

• Published on December 28, 2009

Financial Disclosures

• Prof. Mark Jobling has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.