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- Principles in Bacterial Pathogenesis
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1. The molecular basis of bacterial pathogenicity: an overview
- Prof. B. Brett Finlay
- Gram Negative Pathogens
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2. Deciphering shigella invasion of epithelial cells
- Prof. Philippe Sansonetti
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5. Bordetella pertussis
- Prof. Alison Weiss
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6. Salmonellae: molecular basis of infection
- Prof. Samuel Miller
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7. The diversity of Escherichia coli infections
- Prof. Michael Donnenberg
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8. Bacterial activation of epithelial signaling
- Prof. Alice Prince
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9. Human pathogenic Yersinia species
- Prof. James Bliska
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11. Dental pathogens
- Prof. Ann Progulske-Fox
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12. Haemophilus
- Prof. Robert Munson
- Gram Positive Pathogens
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13. The bacterial pathogen Listeria monocytogenes: an amazing multifaceted model
- Prof. Pascale Cossart
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15. Molecular pathogenesis and prevention of Staphylococcus aureus infections
- Prof. Olaf Schneewind
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16. Streptococcus pyogenes disease and molecular pathogenesis
- Prof. P. Patrick Cleary
- Host Responses
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17. Microbial recognition and the immune response
- Dr. Dana Philpott
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18. Enteric pathogens-microbiota-host inter-kingdom chemical interactions
- Prof. Vanessa Sperandio
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19. Toll-like receptor signalling during infection and inflammation
- Prof. Luke O'Neill
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20. The human indigenous microbiota
- Prof. David Relman
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22. Role of neutrophils in acute lung injury and repair
- Prof. Gregory Downey
- Preventatives and Therapeutics
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23. Antibiotics and antibiotic resistance
- Prof. Gerry Wright
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24. Vaccines: a health insurance of the 21st century
- Prof. Rino Rappuoli
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25. Biodefense vaccines
- Prof. James Nataro
- Archived Lectures *These may not cover the latest advances in the field
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26. Vaccines in the modern world
- Prof. Gordon Dougan
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27. Bacterial infection of epithelial signaling
- Prof. Alice Prince
Printable Handouts
Navigable Slide Index
- Introduction
- Host-pathogen interactions
- Successive steps of human listeriosis
- Listeriosis as a model of infection
- Towards understanding of human listeriosis
- L. monocytogenes discovered by Murray in 1926
- Listeria: the rise of a multifaceted model
- Entry into non phagocytic cells
- Successive steps of cell infectious process
- Cell infectious process: bacterial factors
- The L. monocytogenes virulence gene regulon
- The 5' UTR can adopt a secondary structure
- Thermoregulation of virulence genes
- The prfA-UTR can function as a thermosensor
- Take home messages (1)
- The actin comet-like tails of Listeria (1)
- The actin comet-like tails of Listeria (2)
- The actin-based motility of Listeria
- ActA is responsible for actin based motility
- Arp2/3 - mediated actin assembly
- Listeria is not the only bacterium able to move (1)
- Arp2/3 - mediated motility in Shigella flexneri
- Two types of comet tails
- Listeria is not the only bacterium able to move (2)
- Take home messages (2)
- Bacterial-induced phagocytosis (1)
- Bacterial-induced phagocytosis (2)
- The inlAB operon
- Internalin (InlA)
- E-cadherin homophilic interactions
- Interaction between internalin and E-cadherin (1)
- Role of intra-cytoplasmic domain of E-cadherin
- Arp2/3 recruited at InlA-dependent entry site
- Cortactin, Arp2/3 and actin colocalize at entry
- Recruitment at site of entry summary (1)
- Two-hybrid screen using a-catenin: ARHGAP10
- ARHGAP10 recruited at Listeria entry site
- ARHGAP10 siRNA inhibits a-catenin recruitment
- Recruitment at site of entry summary (2)
- Take home messages (3)
- Interaction between internalin and E-cadherin (2)
- Species-specificity
- Transgenic mice that express human E-cadherin
- Internalin-dependent crossing of intestinal barrier
- Take home messages (4)
- Structure of the internalin-E-cadherin co-crystal
- Pending questions
- InlB, the second invasion protein (1)
- InlB, the second invasion protein (2)
- The InlB signaling pathway
- Endocytosis and degradation of RTKs
- What is clathrin mediated endocytosis?
- Questions
- Listeria and InlB promote ubiquitination of Met
- InlB induces the ubiquitination, endocytosis of Met
- The endocytosis machinery is involved in entry
- Listeria, clathrin and dynamin at entry sites
- Listeria exploits endocytosis machinery to enter
- Model: exploitation of the endocytosis machinery
- Take home messages (5)
- Non classical clathrin recruitment around Listeria
- Actin polymerisation follows clathrin recruitment
- Take home messages (6)
- A rule rather than an exception?
- Zipper mechanism and trigger mechanism
- E. coli, S. aureus and L. innocua recruit clathrin
- Triggering bacteria do not use clathrin
- Clathrin - conclusions
- Summary of InlA and lnlB pathways
- What is the role of InlB in vivo?
- Species specificity of InlB
- No role for InlB in crossing the intestinal barrier
- Take home messages (7)
- InlA and InlB interdependent roles
- Some Listeria express a truncated internalin
- Epidemiological survey on 450 strains
- Anatomy of the human placental barrier
- Study of placenta from patients with listeriosis
- A role for internalin in crossing placental barrier?
- Crossing the placental barrier in-vivo/ex-vivo
- Search for a small animal model
- Entry in gerbil depends on both inlA and inlB
- In vivo imaging of listeriosis in gerbils
- Interdependent roles of InlA, InlB in infection
- Knock-in mice expressing human E16P mEcad
- InlA and InlB - conclusions
- Take home messages (8)
- Comparative genomics
- The bsh gene is absent from Listeria innocua
- BSH is critical for persistence in intestinal tract
- L. monocytogenes and histone modifications
- Chromatin and nucleosome structure
- Histone modifications and transcriptional regulation
- Listeria decreases phosphorylated H3
- Listeria induces specific histone modifications
- LLO induces dephosphorylation of H3
- LLO histone modifications prior to cell invasion
- LLO pathway remains unknown
- LLO induces a specific transcriptional response
- LLO transcription changes and modified histone
- LLO - conclusions
- Perspectives/ future work
- Epigenetics and bacterial infectious diseases
- Contribution of the Listeria model to biology
- Acknowledgments
- Listeria in the cell - image
Topics Covered
- Host-pathogen interactions
- Successive steps of human listeriosis
- Listeriosis: a model of infection
- Listeria monocytogenes : the rise of a multifaceted model
- Entry into non-phagocytic cells
- The cell infection process
- The Listeria monocytogenes virulence gene regulon
- Bacterial-induced phagocytosis
- The inlAB operon
- Internalin
- E-cadherin
- ARHGAP10
- Interaction between Internalin and E-cadherin
- The InlB signaling pathway
- Endocytosis and degradation of RTKs
- Model: exploitation of the endocytosis machinery for invasion of mammalian cells
- Clathrin
- Is the mechanism used by Listeria a rule rather than an exception?
- What is the role of InlB in vivo?
- Epidemiological survey
- InlA and InlB play interdependent roles during feto-placental listeriosis
- Roles of InlA and InlB in infection
- Comparative genomics
- Histone modifications
- Epigenetics and bacterial infectious diseases
- Contribution of the Listeria model to biology
Links
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Talk Citation
Cossart, P. (2009, December 7). The bacterial pathogen Listeria monocytogenes: an amazing multifaceted model [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 31, 2024, from https://doi.org/10.69645/LZOA5469.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Pascale Cossart has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
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