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- Principles in Bacterial Pathogenesis
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1. The molecular basis of bacterial pathogenicity: an overview
- Prof. B. Brett Finlay
- Gram Negative Pathogens
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2. Deciphering shigella invasion of epithelial cells
- Prof. Philippe Sansonetti
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5. Bordetella pertussis
- Prof. Alison Weiss
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6. Salmonellae: molecular basis of infection
- Prof. Samuel Miller
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7. The diversity of Escherichia coli infections
- Prof. Michael Donnenberg
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8. Bacterial activation of epithelial signaling
- Prof. Alice Prince
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9. Human pathogenic Yersinia species
- Prof. James Bliska
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11. Dental pathogens
- Prof. Ann Progulske-Fox
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12. Haemophilus
- Prof. Robert Munson
- Gram Positive Pathogens
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13. The bacterial pathogen Listeria monocytogenes: an amazing multifaceted model
- Prof. Pascale Cossart
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15. Molecular pathogenesis and prevention of Staphylococcus aureus infections
- Prof. Olaf Schneewind
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16. Streptococcus pyogenes disease and molecular pathogenesis
- Prof. P. Patrick Cleary
- Host Responses
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17. Microbial recognition and the immune response
- Dr. Dana Philpott
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18. Enteric pathogens-microbiota-host inter-kingdom chemical interactions
- Prof. Vanessa Sperandio
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19. Toll-like receptor signalling during infection and inflammation
- Prof. Luke O'Neill
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20. The human indigenous microbiota
- Prof. David Relman
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22. Role of neutrophils in acute lung injury and repair
- Prof. Gregory Downey
- Preventatives and Therapeutics
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23. Antibiotics and antibiotic resistance
- Prof. Gerry Wright
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24. Vaccines: a health insurance of the 21st century
- Prof. Rino Rappuoli
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25. Biodefense vaccines
- Prof. James Nataro
- Archived Lectures *These may not cover the latest advances in the field
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26. Vaccines in the modern world
- Prof. Gordon Dougan
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27. Bacterial infection of epithelial signaling
- Prof. Alice Prince
Printable Handouts
Navigable Slide Index
- Introduction
- Legionella pneumophila
- The Legionella lifecycle
- The dot and icm genes
- dot/Icm define type 4 secretory system
- Dot/Icm and intracellular replication
- Endocytic membrane transport
- Dot/Icm effect on endocytic maturation
- Understanding the function of Dot/Icm
- Dot/Icm and transport of Legionella vacuole
- Legionella subverts vesicular transport
- Legionella replication requires vesicular transport
- ARF function is required for ER remodeling
- ER-derived vesicles and Legionella vacuole
- Host GTPases are used for replication
- The Dot/Icm system modulates Arf
- The Dot/Icm system modulates Rab1
- Control of Arf and Rab GTPases
- Identifying Legionella effector proteins
- Identification of ralF
- RalF is translocated to the bacterial cell
- Dot/Icm delivers RalF to the host cell
- RalF defines a new bacterial member of Sec7
- Activation of Arf by Legionella
- How does Legionella modulate Rab1 function?
- Identification of DrrA
- DrrA functions as a GEF factor
- Other Legionella factors that target Rab1
- DrrA is sufficient for Rab1 recruitment
- DrrA is able to dissociate GDI from Rab1
- DrrA has GDI displacement activity
- DrrA has 2 functions
- LepB interacts specifically with Rab1-GTP (1)
- LepB interacts specifically with Rab1-GTP (2)
- LepB is a Rab1 GAP
- Control of Rab1 membrane cycling
- Legionella: the greatest cell biologist on earth
Topics Covered
- The legionella life cycle
- Identification of the dot and icm genes
- The dot and icm genes define a new type IV secretion system
- Intracellular replication
- Endocytic membrane transport
- Transport of the Legionella-containing vacuole
- Legionella replication
- The dot/icm system modulates Arf and Rab1
- Can we identify Legionella proteins that modulate Arf and Rab1 function?
- Activation of Arf by Legionella
- Can Legionella modulate the function of other host GTPases?
- Identification of DrrA
- LepB
- Legionella: The greatest cell biologist on Earth
Links
Series:
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Talk Citation
Roy, C. (2009, October 29). Legionella pneumophila: an intracellular pathogen of phagocytes [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 31, 2024, from https://doi.org/10.69645/VIUB6329.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Craig Roy has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.