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- Perspective and Pathogenesis
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1. Expanding frontiers of cerebrovascular disease
- Prof. Vladimir Hachinski
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2. Basic anatomy, physiology and pathophysiology of the cerebral circulation for the physician
- Prof. Jean-Claude Baron
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3. Pathophysiology of cerebral ischemia
- Prof. Wolf-Dieter Heiss
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4. Intracerebral hemorrhages: causes and clinical findings
- Prof. Louis Caplan
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5. Subarachnoid hemorrhage (SAH)
- Prof. R. Loch Macdonald
- Diagnosis
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6. Clinical diagnosis of stroke and subtypes
- Prof. Louis Caplan
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7. The investigation of stroke
- Dr. Bart Demaerschalk
- Treatment
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8. Acute therapy of stroke and reperfusion treatments
- Prof. Brian Silver
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9. Subarachnoid hemorrhage diagnosis and management
- Prof. Gary K. Steinberg
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10. Stroke-induced heart injury
- Dr. Luciano A. Sposato
- Rehabilitation
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11. Stroke rehabilitation: principles of stroke
- Prof. Robert Teasell
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12. Stroke rehabilitation: therapies and treatments
- Prof. Robert Teasell
- Prevention
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13. Lifestyle and nutrition in stroke prevention
- Prof. J. David Spence
- Special Topics
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15. Pediatric stroke: cerebrovascular injury in the developing brain
- Prof. Adam Kirton
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16. Stroke in women: epidemiology, risk and prevention
- Prof. Cheryl Bushnell
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17. Transient ischemic attack and cognition
- Dr. Jennifer Mandzia
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18. Vascular cognitive impairment
- Prof. Eric E. Smith
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19. Atrial fibrillation, anticoagulation and vitamins for homocysteine
- Prof. J. David Spence
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20. Stroke in the young adult
- Prof. Jeffrey Saver
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21. Stroke in the young
- Dr. Gyan Kumar
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22. Convergence and joint prevention of stroke and dementia
- Prof. Vladimir Hachinski
- Archived Lectures *These may not cover the latest advances in the field
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23. Vascular cognitive impairment
- Dr. John Bowler
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24. Pediatric stroke
- Dr. Gabrielle deVeber
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25. The deteriorating stroke
- Prof. Werner Hacke
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26. General management
- Prof. Bo Norrving
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27. The treatment of stroke: specific management - thrombolysis plus
- Prof. Nils Wahlgren
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28. Rehabilitation: the chronic phase
- Prof. Lalit Kalra
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29. Prevention: management of risk and protective factors
- Prof. Graeme Hankey
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30. Medical therapy for secondary prevention of ischemic stroke
- Prof. Larry Goldstein
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31. Subarachnoid haemorrhage
- Prof. Jan van Gijn
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32. Controversies in stroke
- Prof. Stephen Davies
- Prof. Geoffrey Donnan
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33. Medical and surgical stroke
- Prof. Carlos Kase
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34. The urgency of stroke prevention after TIA
- Prof. S. Claiborne Johnston
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35. Carotid endarterectomy, angioplasty and stenting
- Prof. Martin Brown
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36. The clinical diagnosis of stroke and stroke subtypes
- Prof. Louis Caplan
Printable Handouts
Navigable Slide Index
- Introduction
- Introductory remarks
- The deteriorating IS - content
- Causes of early deterioration after IS (1)
- Causes of early deterioration after IS (2)
- Causes of early deterioration after IS (3)
- Pathophysiology of ischemic brain edema
- Edema formation after ischemic stroke
- Treatment of brain edema
- Pathophysiology of space occupying infarction (1)
- Pathophysiology of space occupying infarction (2)
- Delay of edema-formation and ICP-elevation
- Malignant MCA infarction
- Early neurologic death after stroke (1)
- Complete MCA-infarction imaging
- Herniation imaging
- Early neurologic death after stroke (2)
- Clinical course
- Early diagnosis of malignant MCA infarction
- Early infarct signs
- Natural history and early diagnosis
- Malignant MCA and brain edema
- ICU care for ischemic stroke
- Baseline therapy in severe stroke
- ICP-therapy in stroke (1)
- Medical therapy
- ICP-therapy in stroke (2)
- Hypothermia
- Hypothermia - trauma and cardiac arrest
- How to cool the brain?
- Hypothermia side effects
- Hypothermia - influence on edema formation
- ICP-therapy in stroke (3)
- Decompressive surgery - technical aspects
- Peri-operative ICU treatment
- Results of decompressive surgery
- History of decompressive surgery
- The prospective cohort series (1)
- The prospective cohort series (2)
- Meta-analyses and registries
- The controversy - predictors of outcome
- The controversy - survival vs. quality of life
- The reality of randomized trials for rare conditions
- The 5 randomized clinical trials (1)
- The 5 randomized clinical trials (2)
- The pooled analysis - DESIRE
- Design of the pooled analysis (1)
- Design of the pooled analysis (2)
- Design of the pooled analysis (3)
- Results - distribution of outcome
- Results - primary endpoint
- Conclusions
- Open questions (1)
- Timing of decompressive surgery
- Timing (1)
- Timing (2)
- Open questions (2)
- DESIRE- pooled analysis
- Do we need more evidence from further RCTs?
Topics Covered
- Causes of stroke
- Pathophysiology of ischemic brain edema
- Space occupying infarction
- Treatment of ischemic brain edema
- Causes of early deterioration after ischemic stroke
- Large, space occupying edema
- Edema formation after ischemic stroke
- Treatment of brain edema
- Pathophysiology of space occupying infarction
- Delay between edema formation and ICP-elevation
- Malignant MCA infarction
- Clinical course
- Natural history and early diagnosis
- Malignant MCA and brain edema
- Conservative treatment options
- ICU care for ischemic stroke
- Baseline therapy in severe stroke
- ICP therapy in stroke
- Medical therapy
- Hypothermia
- Decompressive surgery
- The controversy: survival vs. quality of life
- The reality of randomized trials for rare conditions
- The 5 RCTs
- Pooled analysis design
- Results
- Timing
- The need for more evidence for the general approach and not the details
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Hacke, W. (2008, October 27). The deteriorating stroke [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 31, 2024, from https://doi.org/10.69645/PXOA7712.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Werner Hacke has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.