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1. Pharmacog. polym. & drug metab.
2. (P. I) Psychopharmacology and pain
3. Clinical pharmacogenomics
4. Genetic variability of drug response
5. Genetic variability in pharmacokin.
6. Polymorphisms in drug metabolism
7. Genetics-based dose adjustments
8. Polymorphic drug metab. enzymes
9. CYP2D6 - activity in Caucasians
10. Variability in doxepin kinetics
11. Antidep. drug treat. - problems
12. CYP2D6 in antidep. drug treat.
13. CYP2D6 polym. - antidep. drug treat.
14. CYP2D6-based dose adjustments
15. Genotype-based dose adjustments
16. Genotype-phenotype interaction
17. CYP2D6 interethnic differences
18. Influence of polymorphisms in DME
19. Types of adverse drug reactions
20. Antidepressant drug treatment
21. CYP2D6 geno. in ADR patients
22. Adverse effect of antipsychotics
23. CYP2D6 and haloperidol clearance
24. Extrapyramidal sympt. & CYP2D6
25. CYP2D6 - not just a DME
26. CYP2D6 in psychiatry - summary
27. PG polymorphisms in DME
28. Codeine
29. Morphine conc. after codeine treat.
30. CYP2D6 sedat. after codeine treat.
31. Tramadol
32. PG polymorphisms in DME
33. Metabolism of NSAIDs
34. CYP2C genetic locus
35. CYP2C9
36. CYP2C9 - pharmacok. of ibuprofen
37. CYP2C9 - prostaglandin E2
38. CYP2C9 - COX-1 inhibition
39. CYP2C9 - PK differences of NSAIDs
40. Physiologic role of CYP2C8/9
41. CYP inhibitors
42. Conclusion (pain)
43. Acknowledgments

Topics Covered

• Pharmacogenetic polymorphisms
• Biotransformation and clinical outcome
• Consequences of genotyping
• Feasibility for genotyping in antidepressant drug treatment
• Polymorphic cytochrome P450 enzyme CYP2D6
• Feasibility for genotyping in pain treatment
• CYP2C9, CYP2D6 and nonsteroidal analgetic drugs

Links

Series:

• Drug Metabolizing Enzymes

Categories:

• Biochemistry
• Metabolism & Nutrition
• Neuroscience
• Pharmaceutical Sciences

Therapeutic Areas:

• Cardiovascular & Metabolic
• Neurology

Talk Citation

Stingl (formerly Kirchheiner), J. (2007, October 1). Clinical importance of pharmacogenetic polymorphisms affecting drug metabolism: psychopharmacology and pain [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2024, from https://hstalks.com/bs/697/.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Archived on December 10, 2018

Financial Disclosures

• Prof. Julia Stingl (formerly Kirchheiner) has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.