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Navigable Slide Index

1. Methyltransferases
2. Picture of Wilhelm His
3. Methylation of pyridine
4. S-adenosyl-L-methionine
5. Picture of Giulio Cantoni
6. Methionine metabolism
7. Methylation pharmacogenomics
8. Methltransferases - substrates
9. Methyltransferases - enzymes
10. COMT-catalyzed methylation
11. Picture of Julie Axelrod
12. Dopamine catabolism
13. Human COMT gene and mRNA
14. Rat COMT crystal structure
15. Methyltransferase structures (1)
16. Methyltransferase structures (2)
17. Human RBC COMT
18. Human COMT
19. E-COMT activity & 3OMD/LD conc.
20. Human COMT alleles
21. Human liver COMT
22. Human COMT polymorphisms
23. Human COMT allozyme activity (1)
24. Human COMT allozyme activity (2)
25. COMT and schizophrenia
26. Methyltransferases - enzymes
27. Metabolism of 6-mercaptopurine
28. Picture
29. Pharmacogenomic guidance
30. Human RBC TPMT
31. Low/high TPMT
32. Selected human TPMT alleles
33. TPMT gene structure
34. Human TMPT allozyme activity
35. Human TPMT protein (1)
36. Human TPMT protein (2)
37. TMPT genetic polymorphism
38. Aggreosme formation
39. TMPT aggreosme formation
40. TPMT colocalization
41. Protein fold./degrad./aggreg.
42. Methyltransferases - enzymes
43. PNMT - formation of epinephrine
44. Methyltransferase gene structure
45. PNMT polymorphisms
46. PNMT allozyme functional studies
47. PNMT allozyme transl./degrad.
48. PNMT Ala98 allozyme degrad.
49. Methyltransferases - enzymes
50. NNMT
51. Methyltransferase gene structure
52. Methyltransferases - enzymes
53. INMT
54. Methyltransferase gene structure
55. Methltransferases - enzymes
56. Histamine
57. Picture of Henry Dale
58. Histamine metabolism
59. Human HNMT gene
60. Histamine and asthma
61. Methyltransferases - enzymes
62. Picture
63. Arsenic biotransformation
64. Human AS3MT polymorphisms
65. Methyltransferases - enzymes
66. Picture of Wilhelm His
67. Picture of Julie Axelrod
68. S-adenosyl-L-methionine
69. Methionine metabolism

Topics Covered

• Properties, structure, catalytic cycle, isoforms and drug substrate specificity of the main methyltransferase families contributing to drug metabolism
• Regulation of gene expression
• Pharmacogenetics

Links

Series:

• Drug Metabolizing Enzymes

Categories:

• Biochemistry
• Metabolism & Nutrition
• Pharmaceutical Sciences

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on October 30, 2007
• Reviewed on August 29, 2019

Financial Disclosures

• Prof. Richard Weinshilboum has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.