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1. Introduction
2. 48 nuclear receptors in human - many orphans
3. Signal transduction and transcriptional regulation
4. Cofactor binding and transcriptional activation
5. The modular organization of NHRs
6. The DNA binding domain (DBD)
7. Response elements
8. The canonical fold of LBDs
9. LBD: the oligomeric state
10. ER-alpha bound to estradiol
11. PR and AR bound to their ligands
12. RXR-alpha - RAR-alpha
13. NGFI-B
14. Structure of NR bound to DNA
15. Multiple alignments
16. Sequence/structure to function
17. Dimerization and communication pathways in NRs
18. Closer view of RXR and RAR
19. LBD: allosteric control
20. Communication pathway in NRs
21. Allosteric control of hRAR-alpha phosphorylation
22. LBD: ligand binding
23. Plasticity of the LBD
24. The retinoids receptors
25. Mouse trap model
26. Several conformational states of RXR
27. RAR and its activating ligands
28. Mutual adaptation of RAR, RXR and their ligands
29. Structural adaptability of the ecdysone receptor
30. Ecdysone receptor EcR/ ultraspiracle protein USP
31. PonA and natural and synthetic ligands
32. LBD: binding to cofactors
33. Signature motif
34. Cofactor binding and transcriptional activation
35. The LBD with a bound coactivator peptide
36. LBD: ligand dependent (de)activation
37. Estrogen receptor-drug interactions
38. Apo-agonist-antagonist
39. Structural studies on LBD of ERR-gamma
40. ERR3 ligand binding pocket
41. Mechanism of ERR-gamma inactivation by DES
42. The vitamin D receptor (VDR)
43. Crystal structure of the VDR LBD
44. Mutations of VDR LBD found in rickets syndrome
45. Synthetic vitamin D analogs (20-epi compounds)
46. Ligands adapt to the VDR ligand-binding pocket
47. The presence of water channles
48. VDR's ligand binding pocket and 'Gemini' analog
49. Conclusion

Topics Covered

• Signal transduction and transcriptional regulation
• Cofactor binding and transcriptional activation
• The modular organization of nuclear hormone receptors
• The DNA binding domain
• The ligand binding domain
• Sequence/structure to function
• The oligomeric state
• Allosteric control through post-translational modifications
• Communication pathways in NRs
• Ligand binding: specificity and adaptability
• The retinoid receptors: RXR and RAR
• Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor
• Binding to coactivators and corepressors: the signature motifs
• Ligand dependent (de)activation: agonists and antagonists
• Estrogen receptor
• The vitamin D receptor

Links

Series:

• The World of Hormones

Categories:

• Biochemistry

Talk Citation

Moras, D. (2007, December 1). Nuclear receptor superfamily: structural insights into function [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 20, 2024, from https://hstalks.com/bs/485/.
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Publication History

• Published on December 1, 2007
• Archived on August 13, 2020

Financial Disclosures

• Prof. Dino Moras has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.