Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Adeno-associated virus (AAV)
3. AAV classification
4. AAV is a helper dependent parvovirus
5. AAV genetic map
6. AAV Rep proteins
7. Rep functions
8. AAV terminal repeat
9. ITR functions
10. AAV replication
11. Enzymes needed for AAV replication
12. AAV infection
13. Viral entry
14. AAV receptors
15. Illustration of AAV infection
16. VP1 has phosholipase A2 (PlA2) activity
17. Site-specific integration
18. TRP-186
19. AAVS1 (19q13.4)
20. Features of AAV integration
21. AAV for gene therapy
22. Ideal vector
23. How to make an AAV vector
24. Recombinant AAV virus preparation
25. How do you make a lot of vectors
26. Strategies
27. Do recombinant AAV vectors integrate?
28. Diseases targets for AAV
29. AAV in some clinical trials
30. Viral vectors in clinical trials
31. AAV features
32. Conclusions
33. From medical oddity to medical tool!

Topics Covered

• Adeno-associated virus
• Molecular biology
• Persistent infection
• Lack of pathogenicity
• Use as a vector for gene therapy
• Vector structure and properties
• Vector production
• Clinical trials

Links

Series:

• Viruses and Viral Diseases

Categories:

• Genetics & Epigenetics
• Methods
• Microbiology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on September 14, 2017

Financial Disclosures

• Prof. Kenneth Berns has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.