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Talk: Teixobactin kills pathogens without detectable resis... (36 min)

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DETAILED SLIDE INDEX

  1. 1. Introduction
  2. 2. Discovery of antimicrobials
  3. 3. The high-tech platform
  4. 4. Reviving the Waksman platform
  5. 5. Uncultured bacteria
  6. 6. How to grow unculturables
  7. 7. Colonies growth
  8. 8. Diffusion chamber vs. Petri dish
  9. 9. Trap for capturing actinomycetes
  10. 10. iChip
  11. 11. iChip placed in soil
  12. 12. Efficiency of recovery in iChip vs. Petri dish
  13. 13. Diversity in iChip vs. Petri dish
  14. 14. From sand to mechanism
  15. 15. The sand biofilm
  16. 16. Closer look on sand biofilm
  17. 17. The basic mechanism of uncultivability
  18. 18. Growth factors from neighboring species
  19. 19. Siderophore
  20. 20. Siderophore specificity in growth induction
  21. 21. Model for siderophore and unculturable bacteria
  22. 22. Domestication of uncultured producers
  23. 23. Increasing domestication of unculturables
  24. 24. A low-resistance antibiotic
  25. 25. Biochemical pathway
  26. 26. Taxonomy tree of Eleftheria terrae
  27. 27. Teixobactin spectrum
  28. 28. Teixobactin resistance development
  29. 29. Specificity of action
  30. 30. Finding the targets
  31. 31. Teixobactin: mechanism of action
  32. 32. Killing of S. aureus by teixobactin
  33. 33. In vivo efficacy
  34. 34. END

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TALK'S CITATION

Lewis, K. (2015), "Teixobactin kills pathogens without detectable resistance", in Topical Talks: Talks of interest in the biomedical and life sciences, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/?t=BL1003923)

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ABOUT THIS TALK

Speaker(s)

Prof. Kim Lewis Show Biography

SPEAKER BIOGRAPHY

Prof. Kim Lewis – Northeastern University, USA

Kim Lewis is a University Distinguished Professor and Director, Antimicrobial Discovery Center at Northeastern University in Boston, and a Fellow of the American Society of Microbiology. He obtained his Ph.D. in Biochemistry from Moscow University in 1980, and has been on the Faculty of MIT, University of Maryland, and Tufts University prior to coming to Northeastern. Dr. Lewis has authored over 100 papers and is an inventor on several patents. His more notable findings include the development of general methods to grow previously uncultured bacteria that make up >99% of biodiversity on the planet, the discovery of the culprit of recalcitrant biofilm infections, drug-tolerant persister cells; and antimicrobials for sterilizing biofilm infections and killing M. tuberculosis. Dr. Lewis presented over 100 invited talks. Dr. Lewis has been a permanent member of the Drug Discovery and Drug Resistance NIH Study Section, and Chair of two NIH Study Sections on Drug Discovery. Dr. Lewis has served as a panelist and contributor to the National Academies Institute of Medicine reports on antibiotic resistance in 2010, 2011 and 2014, and the European Academies Science Advisory Meeting in 2014. Dr. Lewis is a member of Faculty 1000, a world-wide panel of experts evaluating research advancements. He is a recipient of the MIT C.E. Reed Faculty Initiative Award for an innovative research project (1992), and a recipient of the NIH Director’s Transformative Grant (2009).

Publication Date

April, 2015

Topics Covered

The high-tech & Waksman platforms... more

TOPICS COVERED IN THIS TALK

  • The high-tech & Waksman platforms
  • How to grow unculturable bacteria
  • Diffusion chamber, Petri dish and iChip comparison
  • The sand biofilm
  • Siderophores of neighbouring bacteria
  • Teixobactin: mechanism and efficacy

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  • Recognition of non native proteins by Hsps and formation of aggregates
  • Aggregates and neurodegenerative disease -The discovery of the chaperonin-mediated folding
  • The structure of the GroES/GroeEL chaperonin class of molecular chaperones
  • The steps of polypeptide binding and folding
  • The action of ATP binding and hydrolysis in driving the rings of the machine through cycles of binding and release cycle
Play '37. Vaginal atrophy after menopause'
37. Vaginal atrophy after menopause More info
Prof. JoAnn Pinkerton

TOPICS COVERED IN THIS TALK

  • Vulvovaginal atrophy
  • Physiology of premenopausal vagina
  • Postmenopausal vagina
  • Development of vulvovaginal atrophy
  • Physiology of vulvar and vaginal changes
  • Physical examination of vulva and vagina
  • Vaginal maturation index (VMI or MI)
  • Urethral changes with atrophy
  • Urogenital changes
  • Estrogen levels are decreased postmenopausally
  • First line therapy
  • Non hormonal treatment options
  • Vaginal atrophy treatment duration
  • Vaginal dilators
  • Bladder and urinary symptoms
  • Future options in testing
Play '38. A-to-I RNA editing in human disease'
38. A-to-I RNA editing in human disease More info
Prof. Kazuko Nishikura

TOPICS COVERED IN THIS TALK

  • What is A-to-I RNA editing?
  • Human diseases caused by ADAR1 deficiency
  • Human diseases caused by ADAR2 deficiency
  • Human diseases of 5-HT2CR mRNA editing
  • Human pathological conditions caused by deficiency in microRNA editing

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